Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 44
Special Issue Editor
2. Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
Interests: arginine methylation; epigenetics; transcription; RNA metabolism
Special Issue Information
Dear Colleagues,
Protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), plays essential roles in regulating transcription, RNA splicing, signal transduction, and DNA repair. These methylation events are crucial for normal cellular function and development, orchestrating complex regulatory networks at both the transcriptional and post-transcriptional levels. Dysregulation of PRMT activity has been increasingly linked to a range of human diseases, including neurodevelopmental disorders and cancer. Specifically, aberrant arginine methylation can promote tumor growth, metastasis, and resistance to therapy. In recent years, small molecule inhibitors targeting specific PRMTs have shown promising preclinical and clinical activity, highlighting the therapeutic potential of modulating arginine methylation pathways. As the field rapidly evolves, new mechanistic insights continue to reveal previously unrecognized roles of PRMTs and their substrates across diverse biological systems. This Special Issue invites original research articles and reviews that explore the functions, mechanisms, and therapeutic implications of protein arginine methylation in health and disease, with the goal of advancing both fundamental understanding and translational applications of this modification.
Dr. Yanzhong Yang
Guest Editor
Manuscript Submission Information
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Keywords
- protein arginine methyltransferases
- transcription
- RNA splicing
- signaling transduction
- DNA repair
- cancer
- development
- small molecule inhibitor
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