Mechanistic Insights of Retinal Diseases and Directions for New Therapeutics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1133
Editors
Interests: retinopathy; age-related macular degeneration; angiogenesis; blood–retinal barrier; inflammation; retinal pigment epithelium; Wnt signaling; nuclear receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Retinal diseases are major global health burdens and the leading cause of vision loss worldwide, yet effective therapies remain limited for many conditions. These include age-related macular degeneration, diabetic retinopathy, glaucoma, and inherited retinal degeneration. Progress in the development of new therapeutics depends on mechanistic insights into disease pathogenesis and research on cellular and molecular basis of retinal metabolic homeostasis, neurovascular interaction, and ocular immune responses that are often dysregulated during retinal disease processes. Signaling pathways involving cellular lipid and glucose metabolism, oxidative stress, inflammation, complement, and neuronal protection are central to the pathogenesis of major retinal disorders. Translating these mechanistic insights into clinically effective treatments remains a critical challenge. In this Special Issue, we aim to encompass fundamental research in preclinical models of eye diseases and provide new directions towards potential therapeutics for clinical applications. By integrating mechanistic insights with emerging therapeutic perspectives, this Special Issue seeks to advance our understanding of the pathogenesis of retinal diseases and promote the development of more effective and targeted mechanism-based therapies to ultimately prevent vision loss in children and adults.
Dr. Jing Chen
Dr. Neetu Kushwah
Guest Editors
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Keywords
- retinopathy
- AMD
- retinal degeneration
- ocular pharmacology
- translational therapeutics
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