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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Properties and Functions of Endometrial Stromal Cells—2nd Edition

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 31 Oct 2026 | Viewed by 233 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

Microtubule-Based Motor Proteins in Health and Disease: Mechanisms, Regulation and Cellular Functions

edited by Weihong Qiu

submission deadline 31 Oct 2026 | Viewed by 222 | Submission Open

Keywords: motor proteins; kinesins; dyneins; microtubule

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

High-Field MRI-Guided Boron Neutron Capture Therapy (BNCT): Targeted Delivery and Efficacy Monitoring in Glioma

edited by

Silvia Capuani

and Paola Porcari

submission deadline 31 Oct 2026 | Viewed by 209 | Submission Open

Keywords: boron neutron capture therapy (BNCT); accelerator-based neutron sources; glioma MRI; 19F MRI and MRS; boronophenylalanine (BPA); fluorinated boron agents; glioblastoma; quantitative treatment monitoring; precision radiotherapy; tanslational neuro-oncology

(This special issue belongs to the Section Chemical Biology)

Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition

edited by

Carlo Perricone

submission deadline 1 Nov 2026 | 1 articles | Viewed by 1472 | Submission Open

Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity

(This special issue belongs to the Section Molecular Medicine)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 7 Nov 2026 | 3 articles | Viewed by 6321 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure–activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Research Progress on Anti-Aging with Natural Products

edited by

Sang-Han Lee

submission deadline 10 Nov 2026 | 2 articles | Viewed by 7283 | Submission Open

Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications

(This special issue belongs to the Section Biological Factors)

The Mechanisms of Nervous System Injury

edited by

Krisztián Pajer

and Antal Nógrádi

submission deadline 10 Nov 2026 | Viewed by 207 | Submission Open

Keywords: nervous system injury; neuroprotection; stem cell secretome; inflammasome; extracellular vesicles; neuroinflammation; regenerative medicine; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 17 Nov 2026 | 1 articles | Viewed by 1657 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 Nov 2026 | 4 articles | Viewed by 8369 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators

edited by

Danuta Drozdowska

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3455 | Submission Open

Keywords: 1,3,5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’s activity; anti-Alzheimer’s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity

(This special issue belongs to the Section Chemical Biology)

Molecular Signaling Pathways in Tumorigenesis and Tumor Suppression, 2nd Edition

edited by

Kiyoshi Ohtani

submission deadline 20 Nov 2026 | Viewed by 231 | Submission Open

Keywords: cancer cell biology; RB; E2F; ARF; p53

(This special issue belongs to the Section Molecular Biology)

Translational Insights from Insect Immunity: Antimicrobial Strategies and Infection Models

edited by

Sylwia Stączek

and

Agnieszka Zdybicka-Barabas

submission deadline 20 Nov 2026 | Viewed by 212 | Submission Open

Keywords: insect immunity; antimicrobial peptides; host-pathogen interaction; innate immune response; infection models

(This special issue belongs to the Section Molecular Medicine)

Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies

edited by

Ximena Maria Muresan

and

Ioana Ecaterina Pralea

submission deadline 25 Nov 2026 | 3 articles | Viewed by 4016 | Submission Open

Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy

(This special issue belongs to the Section Molecular Biomarkers)

Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia

edited by

Yong-Mi Kim

submission deadline 25 Nov 2026 | Viewed by 337 | Submission Open

Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment; immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 30 Nov 2026 | 8 articles | Viewed by 14744 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 30 Nov 2026 | 3 articles | Viewed by 13193 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Advances and Novel Strategies for Studying Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 30 Nov 2026 | 3 articles | Viewed by 12177 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

New Insight into the Structures and Host Cell Interactions of Emerging Viruses

edited by

Wei Zhang

and

Qibin Geng

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6046 | Submission Open

Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus–host interactions; viral receptor binding and entry; viral assembly, maturation, and egress; immune evasion; molecular dynamics simulation; antiviral targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Glycomics in Health, Aging and Disease

edited by

Domenico Garozzo

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5240 | Submission Open

Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases

edited by

Ji Chen Bihl

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4646 | Submission Open

Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders

edited by

Raymond Chang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4619 | Submission Open

Keywords: systemic inflammation; neuroinflammation diseases; neurodegenerative diseases; mental disorders

(This special issue belongs to the Section Molecular Medicine)

Novel Insights and Applications of Pluripotent Stem Cells

edited by

Huseyin Sumer

and Ben Rollo

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4487 | Submission Open

Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4288 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Mechanisms and Predictive Biomarkers in Cancer Immunotherapy

edited by Fabrizio Nelli,

Carlo Signorelli

and

Gloria Pessina

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2279 | Submission Open

Keywords: immune checkpoint inhibitors; solid tumors; predictive biomarkers; resistance mechanisms; PD-1/PD-L1 pathway; efficacy; response; immune-related adverse events; real-world evidence

(This special issue belongs to the Section Molecular Biomarkers)

Key Mechanisms in the Pathogenesis of ALS

edited by

Natalia N. Ninkina

and

Michail S. Kukharsky

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2246 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron disease; neurodegeneration; pathogenesis; protein aggregation; non-coding RNA; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Exploring Physical Mechanisms in Inflammation Regulation

edited by

Christine Nardini

and

Vitalii Zablotskii

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2221 | Submission Open

Keywords: physical stimuli; transduction; magnetic field; electric field; magnetotherapy; laser therapy

(This special issue belongs to the Section Biological Factors)

Gut Microbiome and Related Diseases in Animals

edited by

Alessandro Gramenzi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1190 | Submission Open

Keywords: intestinal microbiota; dysbiosis; prebiotic; probiotic; postbiotic; nutraceutical; companion animals

(This special issue belongs to the Section Biological Factors)

Regulation of Bacterial Stress Responses by Sigma Factors: From Transcriptional Control to Metabolic and Physiological Adaptation

edited by Agnese Serafini

submission deadline 30 Nov 2026 | Viewed by 688 | Submission Open

Keywords: sigma factors; environmental stress; bacterial physiology; metabolism

Extracellular Vesicles as Biomarkers of Diseases: 2nd Edition

edited by

Mebarek Saida

and

Leyre Brizuela

submission deadline 30 Nov 2026 | 1 articles | Viewed by 549 | Submission Open

Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential

edited by Umesh Kumar Jinwal

submission deadline 30 Nov 2026 | Viewed by 421 | Submission Open

Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’s Disease; Huntington's disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy

edited by

Takeyori Saheki

submission deadline 30 Nov 2026 | Viewed by 378 | Submission Open

Keywords: citrin deficiency; pathogenesis; therapeutic procedures

(This special issue belongs to the Section Molecular Medicine)

Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights

edited by

Daniëlle Krijgsman

submission deadline 30 Nov 2026 | Viewed by 370 | Submission Open

Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Structural and Functional Insights into Metalloantibiotics

edited by

Li-June Ming

submission deadline 30 Nov 2026 | Viewed by 324 | Submission Open

Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance

(This special issue belongs to the Section Enzymology)

Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease

edited by

Laszlo Bodai

and

Nora Zsindely

submission deadline 30 Nov 2026 | Viewed by 319 | Submission Open

Keywords: Huntington’s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Medicine)

Molecular Insight into Embryogenesis and Organogenesis

edited by

Jihan K. Osborne

submission deadline 30 Nov 2026 | Viewed by 293 | Submission Open

Keywords: morphogenesis; progenitor; differentiation; gastrulation

(This special issue belongs to the Section Molecular Biology)

Natural Product-Inspired Synthesis for Neurological and Oncological Therapeutics

edited by

Sampa Gupta

and

Sushobhan Mukhopadhyay

submission deadline 30 Nov 2026 | Viewed by 281 | Submission Open

Keywords: natural product derivatives; total synthesis; neurotherapeutics; targeted cancer therapy; medicinal chemistry; bioactive scaffolds; drug design

(This special issue belongs to the Section Molecular Medicine)

Molecular and Genetic Basis of Hormonal Signaling and Inter-Organ Crosstalk in Steatotic Liver Disease

edited by Karuna Rasineni and Sundararajan Mahalingam

submission deadline 30 Nov 2026 | Viewed by 280 | Submission Open

Keywords: metabolic liver disease; organ crosstalk; hormones; gut–liver axis; adipose–liver axis; neuroendocrine control of liver function

(This special issue belongs to the Section Molecular Medicine)

Natural and Synthetic Bioactive Compounds: Efficacy and Safety in Chemoprevention

edited by

Monia Lenzi

submission deadline 30 Nov 2026 | Viewed by 273 | Submission Open

Keywords: chemoprevention; bioactive compound; natural products

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Infection in CNS Disease: Neuroinflammation and Brain–Retina Pathology

edited by

Bhakta Prasad Gaire

submission deadline 30 Nov 2026 | Viewed by 267 | Submission Open

Keywords: pathogens; retinal infection; neurodegeneration; pathogen–host interactions

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathogenesis and Immune Evasion in Chronic Lymphocytic Leukemia (CLL)

edited by

Justin Taylor

submission deadline 30 Nov 2026 | Viewed by 263 | Submission Open

Keywords: chronic lymphocytic leukemia; molecular pathogenesis; immune evasion; tumor microenvironment; b-cell receptor signaling; genomic and epigenomic alterations; therapy resistance; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Cannabinoids in Neurobehavioral Modulation: 2nd Edition

edited by

Francisco Navarrete Rueda

and

María S. García Gutiérrez

submission deadline 30 Nov 2026 | Viewed by 245 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Cardiovascular Risk in Rheumatic Diseases: Inflammation, Autoantibodies and Sex Differences

edited by George Karpouzas and

Nicoletta Ronda

submission deadline 30 Nov 2026 | 1 articles | Viewed by 238 | Submission Open

Keywords: sex; sex hormones; disease activity; disease-related autoantibodies; inflammation; cholesterol loading capacity; cholesterol efflux capacity; atherosclerosis; cardiovascular events

(This special issue belongs to the Section Chemical Biology)

RNAs in Health and Disease: Potential Function as Biomarkers and Therapeutic Targets

edited by

Yei-Tsung Chen

submission deadline 30 Nov 2026 | Viewed by 230 | Submission Open

Keywords: non-coding RNAs; biomarkers; RNA therapeutics; metabolic diseases; cardiovascular diseases

(This special issue belongs to the Section Molecular Medicine)

Novel Molecules for Cancer Treatment (4th Edition)

edited by

Javier Martínez-Useros

submission deadline 30 Nov 2026 | Viewed by 230 | Submission Open

Keywords: small-molecule inhibitors; antibody-drug-conjugated (ADC); tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immune checkpoint inhibitors; natural compounds; CAR-T therapy; peptide-based therapeutics; drug delivery systems; drug repurposing; phytochemicals; marine-derived compounds; secondary metabolites; synthetic compounds; bioactive molecules

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Metabolic Plasticity and Epigenetic Rewiring in Solid Tumors

edited by Fabiana Crispo and

Ilaria Laurenzana

submission deadline 30 Nov 2026 | Viewed by 219 | Submission Open

Keywords: metabolomic reprogramming; epigenetic rewiring; tumor microenvironment; phenotypic plasticity; solid tumors; tumor adaptative strategies; therapeutic co-targeting

(This special issue belongs to the Section Molecular Medicine)

Molecular Electronics: Insights and Challenges

edited by

Stuart Lindsay

submission deadline 30 Nov 2026 | Viewed by 215 | Submission Open

Keywords: single-molecule electronics; molecular electronics; single-molecule conductance; charge transport in molecules; nanoscale transport mechanisms; quantum transport in molecular junctions; coherence and dephasing; hopping transport; electron–phonon interactions; ion and proton-coupled transport; electrode–molecule interfaces; charge injection barriers; molecular junctions; scanning probe measurements (STM, cAFM); molecular sensing; label-free detection; molecular-scale devices; molecular assemblies; organic and polymer electronics; biomolecular electronics; protein electronics; DNA electronics; electron transport in DNA; hybrid bioelectronic systems; molecular device integration

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Structure-Based Mechanisms of Protein Functions

edited by Vasiliki Fadouloglou

submission deadline 30 Nov 2026 | Viewed by 214 | Submission Open

Keywords: pseudoenzymes; moonlighting proteins; metamorphic proteins; intrinsically disordered proteins

(This special issue belongs to the Section Molecular Biology)

Immunoregulatory Mechanisms of γδ T Cells and Their Associations with Cancer/Autoimmune Diseases

edited by

Ilan Bank

submission deadline 30 Nov 2026 | Viewed by 211 | Submission Open

Keywords: γδ; T cells; cancer; autoimmunity

(This special issue belongs to the Section Chemical Biology)

Molecular Insights into Myelin Dynamics: From Demyelination to Remyelination in Central Nervous System Diseases

edited by

Domna Karagogeos

submission deadline 30 Nov 2026 | Viewed by 210 | Submission Open

Keywords: demyelination; remyelination; axoglial interactions; myelin plasticity; myelin and aging; myelin and autophagy; activity-dependent myelination; remodeling myelin (mechanisms); myelin and neurodegenerative diseases; multiple sclerosis

(This special issue belongs to the Section Cellular Biochemistry)

Electrochemical Biosensors: From Molecular Recognition to Real World Applications

edited by

Angel A. J. Torriero

submission deadline 30 Nov 2026 | Viewed by 177 | Submission Open

Keywords: electrochemistry; bioelectrochemistry; biosensors

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

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