Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 50
Special Issue Editor
Interests: Alzheimer's disease; neurodegeneration; Parkinson’s disease; Lewy body dementias; neuroimmunology; neuroinflammation; systemic inflammation; tau phosphorylation; gut-brain axis; glial cells; glaucoma
Special Issue Information
Dear Colleagues,
Increasing lines of evidence suggest that both innate and adaptive immune responses in the body (systemic immune responses) can modulate the occurrence of neuroinflammation and activation of both microglia and astrocytes. Consequently, this will affect the progression of neurodegeneration and mental disorders. The body’s immune responses can be stimulated by infection, wound injury, surgery, organ failure, obesity, stress/depression, and even psychiatric disorders. For example, inflammation triggered by periodontitis can further stimulate microglia to accelerate neurodegeneration in Alzheimer’s disease.
The aim of this Special Issue is to investigate (1) in what circumstances systemic immune responses modulate neuroinflammation and disease progression; (2) how immune cells including macrophages, neutrophils, and lymphocytes infiltrate the brain; (3) how these systemic immune cells interact with resident microglia or astrocytes to modulate neuroinflammation; and (4) whether there are any pharmacological and non-pharmacological interventions to prevent systemic inflammation.
We welcome review articles and original research using different animal models to address the abovementioned questions. We particularly encourage reviews that challenge existing hypotheses and schools of thought.
Prof. Dr. Raymond Chuen-Chung Chang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- systemic inflammation
- neuroinflammation diseases
- neurodegenerative diseases
- mental disorders
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
