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Biomolecules
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Research Progress on Anti-Aging with Natural Products
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Research Progress on Anti-Aging with Natural Products

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: 29 March 2026 | Viewed by 2612

Special Issue Editor

Prof. Dr. Sang-Han Lee

E-Mail Website
Guest Editor
Food and Bio-Industry Research Institute, Inner Beauty/Anti-Aging Center, School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: natural products; signaling of polyphenolic nutrients; skin aging and melanogenesis; anti-aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products have long served as a rich source of inspiration and discovery for bioactive compounds with promising anti-aging effects. With recent advances, we now better understand how these compounds work at the molecular level—modulating oxidative stress, inflammation, and autophagy—to help slow down cellular aging and protect the skin from photoaging.

This Special Issue invites you to share your latest original research and insightful reviews that deepen our knowledge of natural compounds with anti-aging potential. We welcome studies that explore everything from chemical profiling and molecular pathways to biological activities and innovative delivery methods that bring these natural wonders closer to real-world applications.

Topics of interest include, but are not limited to, the following:

  • Discovery and extraction of bioactive natural compounds with anti-aging effects.
  • Mechanistic insights into autophagy, oxidative stress, inflammation, and cellular senescence.
  • In vitro, in vivo, and clinical studies evaluating the effectiveness of natural products.
  • Development of novel delivery systems such as biomaterials or nanocarriers.
  • Translational applications in cosmeceuticals, nutraceuticals, and pharmaceuticals.

Please note the following submission criteria for this Special Issue:

  1. Manuscripts focusing solely on natural product extracts, recipes, decoctions, or formulations will be excluded; however, submissions that include clear compositional analysis using methods such as MASS or HPLC, or provide such data as supplementary information, will be considered as exceptions.
  2. Use of appropriate positive controls is mandatory in all experimental studies.
  3. Studies employing biological triplicates are strongly encouraged; technical triplicates alone are insufficient.
  4. During peer review, the participation of graduate students as reviewers will be restricted; priority will be given to expert reviewers with an h-index of 20 or higher.
  5. To enhance publication credibility, submissions with authorship representing diverse nationalities/institutions are preferred.

Prof. Dr. Sang-Han Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • anti-aging signaling
  • autophagy
  • antioxidants
  • skin aging
  • bioactive compounds
  • molecular mechanisms
  • translational applications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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27 pages, 4788 KB  
Article
An Integrated Systems Pharmacology Approach Combining Bioinformatics, Untargeted Metabolomics and Molecular Dynamics to Unveil the Anti-Aging Mechanisms of Tephroseris flammea
by Min Hyung Cho, Haiyan Jin, JangHo Ha, SungJune Chu and SoHee An
Biomolecules 2025, 15(12), 1740; https://doi.org/10.3390/biom15121740 - 15 Dec 2025
Viewed by 236
Abstract
Skin aging, driven by oxidative stress, UV exposure, inflammation, and extracellular matrix degradation, necessitates the discovery of safer, multi-target natural products. We established an integrated pipeline combining UHPLC–MS/MS metabolomics, computational methods (network pharmacology, molecular docking, and dynamics simulation), and in vitro bioassays to [...] Read more.
Skin aging, driven by oxidative stress, UV exposure, inflammation, and extracellular matrix degradation, necessitates the discovery of safer, multi-target natural products. We established an integrated pipeline combining UHPLC–MS/MS metabolomics, computational methods (network pharmacology, molecular docking, and dynamics simulation), and in vitro bioassays to efficiently discover and mechanistically characterize anti-aging compounds from novel botanical sources. We applied this pipeline to identify and evaluate Tephroseris flammea, a previously unassessed plant. Metabolomic profiling identified 21 compounds, including flavonoids, phenylpropanoids, and pyrrolizidine alkaloids. These compounds were linked via network pharmacology to 226 skin-aging-related targets, primarily involving inflammation (via AKT1, RELA) and matrix degradation (via MAPK3). Molecular docking and 100 ns molecular dynamics simulations confirmed stable ligand-target interactions with favorable binding energies. Validating these in silico predictions, the T. flammea extract demonstrated significant antioxidant activity and effectively suppressed key inflammatory mediators (IL-6, TNF-α, COX-2) and MMP-1 levels in UVB-exposed fibroblasts, notably without significant cytotoxicity. Collectively, this study validates the utility of our pipeline to mechanistically characterize complex botanicals, revealing that T. flammea contains multifunctional compounds modulating critical inflammatory and matrix-regulatory cascades. This work validates our pipeline for identifying novel, mechanistically defined ingredients from complex botanical sources. Full article
(This article belongs to the Special Issue Research Progress on Anti-Aging with Natural Products)
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5 pages, 172 KB  
Perspective
Research Progress on Anti-Aging with Natural Products: From Pathway Modulation to AI-Driven Discovery
by Chang Hyung Lee and Sang-Han Lee
Biomolecules 2025, 15(10), 1384; https://doi.org/10.3390/biom15101384 - 29 Sep 2025
Cited by 1 | Viewed by 2129
Abstract
Aging results from the combined effects of oxidative stress, chronic low-grade inflammation, mitochondrial decline, and cellular senescence, which together drive age-related disorders. Natural products ranging from polyphenols and terpenoids to alkaloids, polysaccharides, peptides, and marine metabolites can influence central pathways such as Nrf2/ARE, [...] Read more.
Aging results from the combined effects of oxidative stress, chronic low-grade inflammation, mitochondrial decline, and cellular senescence, which together drive age-related disorders. Natural products ranging from polyphenols and terpenoids to alkaloids, polysaccharides, peptides, and marine metabolites can influence central pathways such as Nrf2/ARE, NF-κB, MAPK, JAK/STAT, AMPK/PGC1-α, mTOR, and SIRT1/FOXO. By doing so, they strengthen antioxidant defenses, temper inflammation, preserve mitochondrial balance, and regulate autophagy. There is increasing attention to synergy, where combinations of bioactives can achieve stronger and more balanced effects than single agents alone. Advances in artificial intelligence are accelerating this discovery process, while greener extraction and smarter delivery systems such as deep eutectic solvents and nanostructured carriers are improving bioavailability and consistency. Together, these developments underscore the promise of natural product-based strategies for healthy aging. Grounded in rigor and reproducibility, this Special Issue aims to inspire translational advances toward healthier and more graceful aging. Full article
(This article belongs to the Special Issue Research Progress on Anti-Aging with Natural Products)
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