Molecular Pathogenesis and Immune Evasion in Chronic Lymphocytic Leukemia (CLL)
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 107
Special Issue Editor
Interests: CLL; precision therapies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic lymphocytic leukemia (CLL) is characterized by marked clinical heterogeneity that is driven by complex interactions between intrinsic molecular lesions and extrinsic immune and microenvironmental factors. While genomic alterations affecting B-cell receptor signaling, the DNA damage response, and epigenetic regulation have transformed our understanding of CLL pathogenesis, durable disease control remains limited by immune evasion and therapy resistance. CLL cells actively remodel the immune microenvironment, impairing T-cell function, antigen presentation, and innate immune surveillance, thereby promoting disease persistence even in the era of targeted therapies.
This Special Issue aims to highlight recent advances in defining the molecular mechanisms underlying CLL initiation, progression, and immune escape, as well as their therapeutic implications. We invite original research articles and comprehensive reviews that explore genomic, epigenomic, metabolic, and signaling pathways in CLL; interactions with the immune microenvironment; and mechanisms of resistance to modern targeted and immunotherapeutic approaches. By integrating molecular pathogenesis with immune biology, this Special Issue seeks to identify vulnerabilities that may inform next-generation precision and immune-based therapies for CLL.
Dr. Justin Taylor
Guest Editor
Manuscript Submission Information
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Keywords
- chronic lymphocytic leukemia
- molecular pathogenesis
- immune evasion
- tumor microenvironment
- b-cell receptor signaling
- genomic and epigenomic alterations
- therapy resistance
- immunotherapy
- precision medicine
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