Key Mechanisms in the Pathogenesis of ALS
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 428
Special Issue Editors
Interests: neurodegeneration; pathomechanisms in proteinopathies; synuclein family; physiological functions of synucleins; chemical neurotransmission; motor neuron disease; animal models of neurological disorders
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative diseases; modeling of neurological disorders; genetically modified animals; amyotrophic lateral sclerosis; long non-coding RNAs; NEAT1
Special Issue Information
Dear Colleagues,
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterized by selective and progressive degeneration of motor neurons. The majority of ALS cases are sporadic, with unknown etiology, whereas approximately 10% are familial forms. To date, more than 40 genes have been identified as being associated with the etiology and/or pathogenesis of ALS. The proteins and non-coding RNAs encoded by these genes are involved in key cellular processes, including protein homeostasis, regulation of cytoskeletal dynamics, RNA metabolism, RNP assembly and dynamics, and DNA repair, highlighting the multifactorial nature of the disease. One of the major roadblocks to the successful development of disease-modifying therapies is still poor understanding of how malfunction of certain molecular mechanisms and pathways leads to the development of ALS and, consequently, the small number of verified therapeutic targets. Another crucial obstruction is the lack of fully validated biomarkers that could be used for diagnostic purposes and monitoring the disease progression in clinical trials.
This Special Issue welcomes original research articles and reviews that provide new insights into various aspects of ALS pathogenesis.
Dr. Natalia N. Ninkina
Dr. Michail S. Kukharsky
Guest Editors
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Keywords
- amyotrophic lateral sclerosis
- motor neuron disease
- neurodegeneration
- pathogenesis
- protein aggregation
- non-coding RNA
- biomarkers
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