Immunoregulatory Mechanisms of γδ T Cells and Their Associations with Cancer/Autoimmune Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 90
Special Issue Editor
Interests: gammadelta T cells; T cell receptor; cancer; autoimmunity; infectious diseases; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
γδ T cells are characterized by their expression of a cell surface membrane-expressed antigen receptor composed of the g and d T cell receptor (TCR) polypeptides. They comprise an evolutionarily conserved lineage that straddles innate and adaptive immunity. Research over the past 40 years, since their discovery, has delineated their unique contribution to homeostatic as well as perturbed immune states, deriving from their ability to recognize pathogen-associated antigens and autoantigens primarily associated with cellular stress in a non-major histocompatibility complex-dependent manner, somewhat reminiscent of immunoglobulins. Furthermore, they exhibit functional overlap with natural killer cells and even with antigen-presenting cells. Thus, although the basic functional repertoire of gd T cells is highly reminiscent of ab T cells, comprising cytotoxic, cytokine production, B cell helper, as well as regulatory functions, it is clear that these cells comprise a non-redundant component of immune responses. In this series, we invite papers relating to the participation of gd T cells in two of the most devastating and highly explored areas of human disease: cancer and autoimmunity. The broad functional repertoire together with the specific characteristics of the gd TCR position these cells as pivotal players in these conditions, as already evident from a multitude of publications in recent years. Our goal is to build upon current knowledge while expanding and deepening our understanding of these fascinating cells, with the ultimate goal of illuminating new ways to alleviate the suffering of the millions of people afflicted by cancer and autoimmune diseases.
Dr. Ilan Bank
Guest Editor
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Keywords
- γδ
- T cells
- cancer
- autoimmunity
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