Structural and Functional Insights into Metalloantibiotics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Enzymology".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Interests: bioinorganic; metallohydrolases; metalloantibiotics; metallodrugs; metallopolymers; paramagnetic NMR; kinetics; oxidation; oxidative stress; reactive oxygen species (ROS); metallo-beta-amyloid
Special Issue Information
Dear Colleagues,
Metalloantibiotics are a distinctive class of antimicrobial agents characterized by the presence of metal ions as integral components, which may include natural and synthetic metal complexes in a broad context. They have garnered increasing attention in recent years due to their unique mechanisms of action and potential to combat drug-resistant pathogens. The structural architecture of metalloantibiotics, encompassing the coordination sphere, ligand types, and molecular geometry, plays a pivotal role in determining their specificity, potency, and broad biological activities. Functional studies have revealed that metalloantibiotics act through diverse pathways, including disruption of microbial cell membranes, inhibition of key enzymatic processes, interference with the synthesis of nucleic acids, proteins, and cell wall, and modulation of redox homeostasis within pathogens.
This Special Issue aims to foster current knowledge on the structural and functional characteristics of metalloantibiotics by exploring how their metal centers influence target recognition and binding, delving into their functional mechanisms, and highlighting the interplay between their structure and biological activity. By integrating structural insights with functional data, we seek to provide a foundation for rational design and optimization of novel metalloantibiotics and offer promising strategies to address the growing challenge of antimicrobial resistance. Submissions of manuscripts regarding structural and functional studies of natural metalloantibiotics and studies of synthetic metalloantibiotics with significant biological, pharmacological, and toxicological aspects are welcome.
Prof. Dr. Li-June Ming
Guest Editor
Manuscript Submission Information
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Keywords
- metal ion
- biomolecules
- enzyme
- antimicrobial resistance
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