The Mechanisms of Nervous System Injury
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 10 November 2026 | Viewed by 34
Special Issue Editors
Interests: neurosurgery; nerve injury
Special Issue Information
Dear Colleagues,
The mechanisms of nervous system injury comprise a complex array of molecular, cellular, and systemic processes contributing to acute damage followed by long-term dysfunction. Whether triggered by trauma, ischemia, neurodegeneration, or inflammation, these injuries are driven by intricate cascades involving oxidative stress, excitotoxicity, neuroinflammation and mitochondrial dysfunction.
Recent advances highlighted in this Special Issue of Biomolecules emphasize the role of biomolecular interactions in propagating neural damage. Key factors such as inflammasome activation, pro-inflammatory cytokines and misfolded proteins disrupt cellular homeostasis, while the interplay between neurons, glial cells, and the extracellular matrix further modulates recovery.
According to the various pathomechanisms, a number of therapeutic approaches have been developed in the past decades. Along the various classical pharmacological agents, specially designed biomolecules play a crucial role in inhibiting neuroinflammation, modulating the injury microenvironment and enhancing tissue repair and regeneration. In this context, stem cells and their secretome have emerged as effective and transformative therapeutic tools. Recent evidence suggests that stem cell-derived factors including extracellular vesicles, growth factors, and cytokines exert potent neuroprotective and regenerative effects.
By integrating findings from morphology, molecular biology, biochemistry and regenerative medicine, this Special Issue provides a comprehensive overview of injury mechanisms and highlights innovative therapeutic strategies for clinical application.
Dr. Krisztián Pajer
Prof. Dr. Antal Nógrádi
Guest Editors
Manuscript Submission Information
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Keywords
- nervous system injury
- neuroprotection
- stem cell secretome
- inflammasome
- extracellular vesicles
- neuroinflammation
- regenerative medicine
- molecular mechanisms
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