Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 6
Special Issue Editor
Interests: leukemia; drug resistance; microenvironment; integrin; acute lymphoblastic leukemia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Therapy resistance remains a major obstacle to curing acute myeloid leukemia (AML). Relapse often reflects the convergence of clonal evolution, the persistence and plasticity of leukemia stem cells, protective cues from the bone marrow niche, and adaptive epigenetic and metabolic programs. Closing these gaps requires mechanistic insight tightly linked to biomarkers and therapeutic strategies that can be tested in patients. A deeper understanding of the molecular and cellular mechanisms contributing to therapy resistance is needed to understand the biology of AML and to design novel strategies with which to target AML cells.
This Special Issue will explore the molecular pathogenesis of AML, biological insights into leukemia stem cells, the microenvironment of AML cells, therapy resistance, novel therapeutic targets, and immunotherapy and clinical trials in AML.
We invite original research articles, brief reports, comprehensive or focused reviews, and method/resource papers. Our goal is to assemble a collection that deepens biological understanding and points to actionable, testable strategies for durable remissions in AML. We look forward to your contributions.
Prof. Dr. Yong-Mi Kim
Guest Editor
Manuscript Submission Information
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Keywords
- acute myeloid leukemia
- molecular mechanism
- cellular mechanism
- therapy resistance
- microenvironment
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