Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 30 June 2025 | Viewed by 959
Special Issue Editors
Interests: infectious diseases; inflammation; COVID-19; nosocomial infections; outbreak
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress; inflammation; metabolism; non-communicable diseases; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute respiratory infections (ARIs) are a pressing issue, particularly among vulnerable populations. While these infections are primarily viral and often self-limiting, they remain the leading cause of antibiotic prescriptions worldwide. However, ARIs can escalate, requiring hospitalization and significantly impacting morbidity and mortality. Respiratory syncytial virus and various strains of influenza, especially influenza A and SARS-CoV-2, play central roles in the spectra of these diseases. The rapid diagnosis and identification of individuals at risk of severe progression are critical for timely and effective treatment.
Recently, there has also been a rise in herpes virus infections, highlighting the importance of understanding common mechanisms across viral diseases to improve treatment strategies. Increased oxidative stress, resulting from the infection and the macrophage-driven immune response, disrupts endogenous antioxidant systems and compromises mitochondrial function. This disruption leads to significant alterations in glycolysis, lipid, and amino acid metabolism, triggering an amplified inflammatory response and exacerbating the severity of symptoms. Research indicates that patients with chronic metabolic diseases are at higher risk of developing severe ARIs, as evidenced by those with atherosclerosis and COVID-19.
This Special Issue invites original research papers and reviews exploring the connections between metabolic pathways and ARIs. We believe that collaboration is key to advancing our understanding and treatment of these diseases. We welcome mechanistic studies in patients, experimental animal models, or cell cultures, as well as research identifying potential metabolic biomarkers for diagnosis, prognosis, or disease monitoring. Additionally, submissions that focus on novel treatments, such as pharmacological or involving bioactive compounds, and the discovery of new therapeutic targets are highly encouraged. Your contribution to this collaborative effort is crucial.
Dr. Simona Iftimie
Dr. Jordi Camps
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- COVID-19
- respiratory syncytial virus
- influenza
- SARS-CoV-2
- viral acute respiratory infections
- metabolic pathways
- herpes virus
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