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  • Review
  • Open Access
223 Citations
56,567 Views
25 Pages

The lack of consistent presentation of results in published studies on the association between a quantitative explanatory variable and a quantitative dependent variable has been a long-term issue in evaluating the reported findings. Studies are analy...

(This article belongs to the Special Issue Feature Papers in Medical Statistics and Data Science Section)
  • Review
  • Open Access
75 Citations
37,199 Views
40 Pages

Generative Artificial Intelligence in Healthcare: Applications, Implementation Challenges, and Future Directions

  • Syed Arman Rabbani,
  • Mohamed El-Tanani,
  • Shrestha Sharma,
  • Syed Salman Rabbani,
  • Yahia El-Tanani,
  • Rakesh Kumar and
  • Manita Saini

Generative artificial intelligence (AI) is rapidly transforming healthcare systems since the advent of OpenAI in 2022. It encompasses a class of machine learning techniques designed to create new content and is classified into large language models (...

(This article belongs to the Special Issue Integrating Health Informatics and Artificial Intelligence for Advanced Medicine)
  • Systematic Review
  • Open Access
20 Citations
28,105 Views
14 Pages

Networks in Healthcare: A Systematic Review

  • Santhosh Kumar Rajamani and
  • Radha Srinivasan Iyer

Networks form the backbone of any healthcare system. Various databases were searched with relevant keywords, data were abstracted, and numerous papers were appraised for this synthesis. This compiled systematic review gives a comprehensive overview o...

(This article belongs to the Section Clinical Informatics)
  • Review
  • Open Access
86 Citations
27,503 Views
47 Pages

Recent Advances in Large Language Models for Healthcare

  • Khalid Nassiri and
  • Moulay A. Akhloufi

Recent advances in the field of large language models (LLMs) underline their high potential for applications in a variety of sectors. Their use in healthcare, in particular, holds out promising prospects for improving medical practices. As we highlig...

(This article belongs to the Special Issue Feature Papers in Clinical Informatics Section)
  • Article
  • Open Access
26 Citations
24,390 Views
19 Pages

Aedes Larva Detection Using Ensemble Learning to Prevent Dengue Endemic

  • Md Shakhawat Hossain,
  • Md Ezaz Raihan,
  • Md Sakir Hossain,
  • M. M. Mahbubul Syeed,
  • Harunur Rashid and
  • Md Shaheed Reza

Dengue endemicity has become regular in recent times across the world. The numbers of cases and deaths have been alarmingly increasing over the years. In addition to this, there are no direct medications or vaccines to treat this viral infection. Thu...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Review
  • Open Access
99 Citations
23,236 Views
33 Pages

Genomics for Emerging Pathogen Identification and Monitoring: Prospects and Obstacles

  • Vishakha Vashisht,
  • Ashutosh Vashisht,
  • Ashis K. Mondal,
  • Jaspreet Farmaha,
  • Ahmet Alptekin,
  • Harmanpreet Singh,
  • Pankaj Ahluwalia,
  • Anaka Srinivas and
  • Ravindra Kolhe

Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemic highlight...

(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
  • Review
  • Open Access
131 Citations
22,894 Views
49 Pages

Deep learning has emerged as a powerful tool for medical image analysis and diagnosis, demonstrating high performance on tasks such as cancer detection. This literature review synthesizes current research on deep learning techniques applied to lung c...

(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
  • Review
  • Open Access
72 Citations
21,754 Views
18 Pages

Artificial Intelligence: The Milestone in Modern Biomedical Research

  • Konstantina Athanasopoulou,
  • Glykeria N. Daneva,
  • Panagiotis G. Adamopoulos and
  • Andreas Scorilas

In recent years, the advent of new experimental methodologies for studying the high complexity of the human genome and proteome has led to the generation of an increasing amount of digital information, hence bioinformatics, which harnesses computer s...

(This article belongs to the Section Computational Biology and Medicine)
  • Review
  • Open Access
37 Citations
20,973 Views
27 Pages

Ultrasound Elastography: Basic Principles and Examples of Clinical Applications with Artificial Intelligence—A Review

  • Maurizio Cè,
  • Natascha Claudia D'Amico,
  • Giulia Maria Danesini,
  • Chiara Foschini,
  • Giancarlo Oliva,
  • Carlo Martinenghi and
  • Michaela Cellina

Ultrasound elastography (USE) or elastosonography is an ultrasound-based, non-invasive imaging method for assessing tissue elasticity. The different types of elastosonography are distinguished according to the mechanisms used for estimating tissue el...

(This article belongs to the Section Imaging Informatics)
  • Article
  • Open Access
7 Citations
19,237 Views
19 Pages

Analysis of Single-Cell RNA-Sequencing Data: A Step-by-Step Guide

  • Aanchal Malhotra,
  • Samarendra Das and
  • Shesh N. Rai

Single-cell RNA-sequencing (scRNA-seq) technology provides an excellent platform for measuring the expression profiles of genes in heterogeneous cell populations. Multiple tools for the analysis of scRNA-seq data have been developed over the years. T...

(This article belongs to the Special Issue Current Trends and Developments in Bioinformatics and Statistical Research from a Biomedical Aspect)
  • Review
  • Open Access
41 Citations
18,972 Views
64 Pages

Lung cancer is a leading cause of cancer-related deaths worldwide, emphasizing the significance of early detection. Computer-aided diagnostic systems have emerged as valuable tools for aiding radiologists in the analysis of medical images, particular...

(This article belongs to the Topic Real-Time Monitoring for Improving Cancer Diagnosis and Prognosis)
  • Review
  • Open Access
101 Citations
17,248 Views
22 Pages

Digital twins (DTs) are becoming increasingly popular in various industries, and their potential for healthcare in the metaverse continues to attract attention. The metaverse is a virtual world where individuals interact with digital replicas of them...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Review
  • Open Access
34 Citations
16,926 Views
17 Pages

Artificial Intelligence in Wound Care: A Narrative Review of the Currently Available Mobile Apps for Automatic Ulcer Segmentation

  • Davide Griffa,
  • Alessio Natale,
  • Yuri Merli,
  • Michela Starace,
  • Nico Curti,
  • Martina Mussi,
  • Gastone Castellani,
  • Davide Melandri,
  • Bianca Maria Piraccini and
  • Corrado Zengarini

Introduction: Chronic ulcers significantly burden healthcare systems, requiring precise measurement and assessment for effective treatment. Traditional methods, such as manual segmentation, are time-consuming and error-prone. This review evaluates th...

(This article belongs to the Section Imaging Informatics)
  • Review
  • Open Access
32 Citations
16,648 Views
70 Pages

Advancements in Breast Cancer Detection: A Review of Global Trends, Risk Factors, Imaging Modalities, Machine Learning, and Deep Learning Approaches

  • Md. Atiqur Rahman,
  • M. Saddam Hossain Khan,
  • Yutaka Watanobe,
  • Jarin Tasnim Prioty,
  • Tasfia Tahsin Annita,
  • Samura Rahman,
  • Md. Shakil Hossain,
  • Saddit Ahmed Aitijjo,
  • Rafsun Islam Taskin and
  • Touhid Bhuiyan
  • + 2 authors

Breast cancer remains a critical global health challenge, with over 2.1 million new cases annually. This review systematically evaluates recent advancements (2022–2024) in machine and deep learning approaches for breast cancer detection and ris...

(This article belongs to the Section Imaging Informatics)
  • Article
  • Open Access
13 Citations
16,331 Views
20 Pages

Chest X-ray Abnormality Detection by Using Artificial Intelligence: A Single-Site Retrospective Study of Deep Learning Model Performance

  • Daniel Kvak,
  • Anna Chromcová,
  • Marek Biroš,
  • Robert Hrubý,
  • Karolína Kvaková,
  • Marija Pajdaković and
  • Petra Ovesná

Chest X-ray (CXR) is one of the most common radiological examinations for both nonemergent and emergent clinical indications, but human error or lack of prioritization of patients can hinder timely interpretation. Deep learning (DL) algorithms have p...

(This article belongs to the Section Imaging Informatics)
  • Review
  • Open Access
11 Citations
15,921 Views
25 Pages

The Role of Artificial Intelligence in Pharmacy Practice and Patient Care: Innovations and Implications

  • Aftab Alam,
  • Syed Sikandar Shah,
  • Syed Arman Rabbani and
  • Mohamed El-Tanani

Artificial Intelligence (AI) is reshaping pharmacy practice by enhancing decision-making, personalizing therapy, and improving medication safety. AI applications now span drug discovery, clinical decision support, and adherence monitoring. This narra...

  • Article
  • Open Access
97 Citations
15,376 Views
17 Pages

The use of artificial intelligence (AI) systems in biomedical and clinical settings can disrupt the traditional doctor–patient relationship, which is based on trust and transparency in medical advice and therapeutic decisions. When the diagnosi...

(This article belongs to the Special Issue Explainable Artificial Intelligence (XAI) in Biomedical Research and Clinical Practice)
  • Review
  • Open Access
13 Citations
14,350 Views
24 Pages

Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software

  • Anna Maria Pavone,
  • Antonino Giulio Giannone,
  • Daniela Cabibi,
  • Simona D’Aprile,
  • Simona Denaro,
  • Giuseppe Salvaggio,
  • Rosalba Parenti,
  • Anthony Yezzi and
  • Albert Comelli

In the era of digitalization, the biomedical sector has been affected by the spread of artificial intelligence. In recent years, the possibility of using deep and machine learning methods for clinical diagnostic and therapeutic interventions has been...

(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
  • Article
  • Open Access
42 Citations
14,084 Views
12 Pages

Background: Currently, discriminating Iron Deficiency Anemia (IDA) from other anemia requires an expensive test (serum ferritin). Complete Blood Count (CBC) tests are less costly and more widely available. Machine learning models have not yet been ap...

(This article belongs to the Special Issue Editor's Choice Series for the Applied Biomedical Data Science Section)
  • Review
  • Open Access
15 Citations
13,968 Views
24 Pages

Current Applications of Artificial Intelligence in the Neonatal Intensive Care Unit

  • Dimitrios Rallis,
  • Maria Baltogianni,
  • Konstantina Kapetaniou and
  • Vasileios Giapros

Artificial intelligence (AI) refers to computer algorithms that replicate the cognitive function of humans. Machine learning is widely applicable using structured and unstructured data, while deep learning is derived from the neural networks of the h...

  • Systematic Review
  • Open Access
16 Citations
12,831 Views
27 Pages

With the increase in biosensors and data collection devices in the healthcare industry, artificial intelligence and machine learning have attracted much attention in recent years. In this study, we offered a comprehensive review of the current trends...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Feature Paper
  • Article
  • Open Access
11 Citations
12,507 Views
10 Pages

Minimal Hip Joint Space Width Measured on X-rays by an Artificial Intelligence Algorithm—A Study of Reliability and Agreement

  • Anne Mathilde Andersen,
  • Benjamin S. B. Rasmussen,
  • Ole Graumann,
  • Søren Overgaard,
  • Michael Lundemann,
  • Martin Haagen Haubro,
  • Claus Varnum,
  • Janne Rasmussen and
  • Janni Jensen

Minimal joint space width (mJSW) is a radiographic measurement used in the diagnosis of hip osteoarthritis. A large variance when measuring mJSW highlights the need for a supporting diagnostic tool. This study aimed to estimate the reliability of a d...

(This article belongs to the Section Imaging Informatics)
  • Review
  • Open Access
90 Citations
12,505 Views
16 Pages

This review explores the transformative integration of artificial intelligence (AI) and healthcare through conversational AI leveraging Natural Language Processing (NLP). Focusing on Large Language Models (LLMs), this paper navigates through various...

(This article belongs to the Special Issue Computational Biology and Artificial Intelligence in Medicine)
  • Review
  • Open Access
68 Citations
12,422 Views
14 Pages

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand–supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art computer...

(This article belongs to the Special Issue Explainable Artificial Intelligence (XAI) in Biomedical Research and Clinical Practice)
  • Article
  • Open Access
16 Citations
11,853 Views
12 Pages

A Comprehensive Analysis of Trapezius Muscle EMG Activity in Relation to Stress and Meditation

  • Mohammad Ahmed,
  • Michael Grillo,
  • Amirtaha Taebi,
  • Mehmet Kaya and
  • Peshala Thibbotuwawa Gamage

Introduction: This study analyzes the efficacy of trapezius muscle electromyography (EMG) in discerning mental states, namely stress and meditation. Methods: Fifteen healthy participants were monitored to assess their physiological responses to menta...

(This article belongs to the Section Clinical Informatics)
  • Review
  • Open Access
56 Citations
11,596 Views
26 Pages

Artificial Intelligence (AI) and deep learning models have revolutionized diagnosis, prognostication, and treatment planning by extracting complex patterns from medical images, enabling more accurate, personalized, and timely clinical decisions. Desp...

(This article belongs to the Section Imaging Informatics)
  • Article
  • Open Access
25 Citations
11,559 Views
16 Pages

Breast cancer is among the most common cancers found in women, causing cancer-related deaths and making it a severe public health issue. Early prediction of breast cancer can increase the chances of survival and promote early medical treatment. Moreo...

(This article belongs to the Special Issue Feature Papers in Computational Biology and Medicine)
  • Review
  • Open Access
3 Citations
11,541 Views
15 Pages

Radiation-induced gastrointestinal (GI) dose constraints are still a matter of concern with the ongoing evolution of patient outcomes and treatment-related toxicity in the era of image-guided intensity-modulated radiation therapy (IMRT), stereotactic...

(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
  • Article
  • Open Access
16 Citations
11,467 Views
15 Pages

The three-dimensional protein structure is pivotal in comprehending biological phenomena. It directly governs protein function and hence aids in drug discovery. The development of protein prediction algorithms, such as AlphaFold2, ESMFold, and trRose...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Article
  • Open Access
47 Citations
11,331 Views
26 Pages

Supporting the Demand on Mental Health Services with AI-Based Conversational Large Language Models (LLMs)

  • Tin Lai,
  • Yukun Shi,
  • Zicong Du,
  • Jiajie Wu,
  • Ken Fu,
  • Yichao Dou and
  • Ziqi Wang

The demand for psychological counselling has grown significantly in recent years, particularly with the global outbreak of COVID-19, which heightened the need for timely and professional mental health support. Online psychological counselling emerged...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Communication
  • Open Access
47 Citations
11,329 Views
21 Pages

The Crucial Role of Interdisciplinary Conferences in Advancing Explainable AI in Healthcare

  • Ankush U. Patel,
  • Qiangqiang Gu,
  • Ronda Esper,
  • Danielle Maeser and
  • Nicole Maeser

As artificial intelligence (AI) integrates within the intersecting domains of healthcare and computational biology, developing interpretable models tailored to medical contexts is met with significant challenges. Explainable AI (XAI) is vital for fos...

(This article belongs to the Topic Computational Intelligence and Bioinformatics (CIB))
  • Article
  • Open Access
7 Citations
11,042 Views
16 Pages

An interesting issue observed in some drugs is the “double peak phenomenon” (DPP). In DPP, the concentration-time (C-t) profile does not follow the usual shape but climbs to a peak and then begins to degrade before rising again to a secon...

(This article belongs to the Special Issue Feature Papers in Computational Biology and Medicine)
  • Review
  • Open Access
21 Citations
10,758 Views
26 Pages

Background: Over the past few years, clinical studies have utilized machine learning in telehealth and smart care for disease management, self-management, and managing health issues like pulmonary diseases, heart failure, diabetes screening, and intr...

(This article belongs to the Special Issue Feature Papers in Clinical Informatics Section)
  • Review
  • Open Access
9 Citations
10,747 Views
14 Pages

Artificial Intelligence as Assessment Tool in Occupational Therapy: A Scoping Review

  • Christos Kokkotis,
  • Ioannis Kansizoglou,
  • Theodoros Stampoulis,
  • Erasmia Giannakou,
  • Panagiotis Siaperas,
  • Stavros Kallidis,
  • Maria Koutra,
  • Christina Koutra,
  • Anastasia Beneka and
  • Evangelos Bebetsos

Occupational therapy (OT) is vital in improving functional outcomes and aiding recovery for individuals with long-term disabilities, particularly those resulting from neurological diseases. Traditional assessment methods often rely on clinical judgme...

  • Review
  • Open Access
50 Citations
10,730 Views
16 Pages

This article delves into the intersection of generative AI and digital twins within drug discovery, exploring their synergistic potential to revolutionize pharmaceutical research and development. Through various instances and examples, we illuminate...

(This article belongs to the Special Issue Advances in Structural Bioinformatics and Next-Generation Sequence Analysis for Drug Design)
  • Review
  • Open Access
9 Citations
10,710 Views
13 Pages

Unobtrusive Monitoring of Sleep Cycles: A Technical Review

  • Juwonlo Siyanbade,
  • Bessam Abdulrazak and
  • Ibrahim Sadek

Polysomnography is the gold-standard method for measuring sleep but is inconvenient and limited to a laboratory or a hospital setting. As a result, the vast majority of patients do not receive a proper diagnosis. In an attempt to solve this issue, sl...

  • Review
  • Open Access
18 Citations
10,381 Views
22 Pages

The adoption of “artificial intelligence (AI) in drug discovery”, where AI is used in the process of pharmaceutical research and development, is progressing. By using the ability to process large amounts of data, which is a characteristic...

(This article belongs to the Section Applied Biomedical Data Science)
  • Article
  • Open Access
29 Citations
10,310 Views
25 Pages

Survey of Multimodal Medical Question Answering

  • Hilmi Demirhan and
  • Wlodek Zadrozny

Multimodal medical question answering (MMQA) is a vital area bridging healthcare and Artificial Intelligence (AI). This survey methodically examines the MMQA research published in recent years. We collect academic literature through Google Scholar, a...

(This article belongs to the Topic Computational Intelligence and Bioinformatics (CIB))
  • Article
  • Open Access
84 Citations
10,196 Views
14 Pages

An LDA–SVM Machine Learning Model for Breast Cancer Classification

  • Onyinyechi Jessica Egwom,
  • Mohammed Hassan,
  • Jesse Jeremiah Tanimu,
  • Mohammed Hamada and
  • Oko Michael Ogar

Breast cancer is a prevalent disease that affects mostly women, and early diagnosis will expedite the treatment of this ailment. Recently, machine learning (ML) techniques have been employed in biomedical and informatics to help fight breast cancer....

  • Article
  • Open Access
13 Citations
10,014 Views
9 Pages

An IoT-Based Automatic and Continuous Urine Measurement System

  • Alexander Lee,
  • Melissa Lee and
  • Hsi-Jen James Yeh

Urine output is an important indicator of renal function. In hospitals, urine is collected using a catheter connected to a urine collection bag that has volume gradation markings. This type of visual measurement has low levels of accuracy and is labo...

(This article belongs to the Section Computational Biology and Medicine)
  • Article
  • Open Access
38 Citations
9,945 Views
15 Pages

Real-Time Jaundice Detection in Neonates Based on Machine Learning Models

  • Ahmad Yaseen Abdulrazzak,
  • Saleem Latif Mohammed,
  • Ali Al-Naji and
  • Javaan Chahl

Introduction: Despite the many attempts made by researchers to diagnose jaundice non-invasively using machine learning techniques, the low amount of data used to build their models remains the key factor limiting the performance of their models. Obje...

(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
  • Review
  • Open Access
5 Citations
9,900 Views
26 Pages

Background: Nowadays, much research deals with the application of the automated meta-analysis of clinical trials through appropriate machine learning tools to extract the results that can then be applied in daily clinical practice. Methods: The autho...

(This article belongs to the Special Issue Feature Papers in Medical Statistics and Data Science Section)
  • Article
  • Open Access
20 Citations
9,824 Views
21 Pages

Background: Epilepsy is one of the most common and devastating neurological disorders, manifesting with seizures and affecting approximately 1–2% of the world’s population. The criticality of seizure occurrence and associated risks, combi...

(This article belongs to the Special Issue Editor's Choices Series for Methods in Biomedical Informatics Section)
  • Article
  • Open Access
15 Citations
9,793 Views
26 Pages

Synthetic MRI Generation from CT Scans for Stroke Patients

  • Jake McNaughton,
  • Samantha Holdsworth,
  • Benjamin Chong,
  • Justin Fernandez,
  • Vickie Shim and
  • Alan Wang

CT scans are currently the most common imaging modality used for suspected stroke patients due to their short acquisition time and wide availability. However, MRI offers superior tissue contrast and image quality. In this study, eight deep learning m...

(This article belongs to the Topic Machine Learning Techniques Driven Medicine Analysis)
  • Review
  • Open Access
19 Citations
9,675 Views
17 Pages

This review explores the integration of artificial intelligence (AI) and machine learning (ML) into kidney transplantation (KT), set against the backdrop of a significant donor organ shortage and the evolution of ‘Next-Generation Healthcare&rsq...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Data Descriptor
  • Open Access
15 Citations
9,546 Views
10 Pages

NJN: A Dataset for the Normal and Jaundiced Newborns

  • Ahmad Yaseen Abdulrazzak,
  • Saleem Latif Mohammed and
  • Ali Al-Naji

Neonatal jaundice is a prevalent condition among newborns, with potentially severe complications that can result in permanent brain damage if left untreated during its early stages. The existing approaches for jaundice detection involve invasive proc...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
  • Article
  • Open Access
12 Citations
9,505 Views
42 Pages

Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have...

(This article belongs to the Section Applied Biomedical Data Science)
  • Article
  • Open Access
56 Citations
9,491 Views
14 Pages

A common consequence of diabetes mellitus called diabetic retinopathy (DR) results in lesions on the retina that impair vision. It can cause blindness if not detected in time. Unfortunately, DR cannot be reversed, and treatment simply keeps eyesight...

(This article belongs to the Special Issue Advances in Quantitative Imaging Analysis: From Theory to Practice)
  • Article
  • Open Access
24 Citations
9,443 Views
20 Pages

Previous studies demonstrate the feasibility of predicting obesity using various machine learning techniques; however, these studies do not address the limitations of these methods in real-life settings where available data for children may vary. We...

(This article belongs to the Topic Machine Learning Techniques Driven Medicine Analysis)
  • Perspective
  • Open Access
15 Citations
9,421 Views
13 Pages

AlphaFold2 Update and Perspectives

  • Sébastien Tourlet,
  • Ragousandirane Radjasandirane,
  • Julien Diharce and
  • Alexandre G. de Brevern

Access to the three-dimensional (3D) structural information of macromolecules is of major interest in both fundamental and applied research. Obtaining this experimental data can be complex, time consuming, and costly. Therefore, in silico computation...

(This article belongs to the Special Issue Deep Learning Methods and Application for Bioinformatics and Healthcare)
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