Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 1866
Special Issue Editors
2. Unidad de Paciente Crítico, Hospital del Salvador, Santiago 7500922, Chile
Interests: cardiovascular physiology and pathophysiology; animal models of intermittent hypoxia; cardiotoxicity; internal medicine; clinical trial
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hypoxic (HI) injury involves the worsening of organ dysfunction and cell death due to reduced blood flow, often caused by organ targeting or increased oxygen demand. While restoring blood flow is crucial to save ischemic tissues, reperfusion can cause additional damage, leading to reversible and irreversible changes in tissue and organ function. This is the basic pathophysiology of ischemia-reperfusion (IR) injury, particularly oxidative stress and cell death mechanisms. During reperfusion, local inflammation and oxidative stress increase, causing secondary injury. IR injury affects various organs, including the heart, lungs, kidneys, and brain, and neuroendocrine system, may induce systemic damage, potentially leading to multisystem organ and metabolic dysfunction. Similar responses occur in humans, especially in patients with acute and chronic hypoxia, intermittent hypoxia and hyperoxia expositions. Additionally, in certain cancers, like breast and colon, oxidative stress and hypoxia can lead to distant effects, such as cardio and lung toxicity. Finally, recent evidence suggests the implications of HI and oxidative stress in exercise preconditioning associated with Hyperbaric Oxygen Therapy (HBOT), and their clinical applications.
This Special Issue builds on the success of the First Edition, which features more than 10 interesting papers. In this Second Edition, we will continue to gather research articles and reviews that cover, but are not limited to, the following topics:
- Current concepts of pathophysiology and therapies in cardiac HI and pharmacological preconditioning;
- Current concepts of pathophysiology and therapies in HI signaling in skeletal muscle physiology;
- Current concepts of cancer therapy related-cardiac dysfunction in breast cancer and cancer survivors, oxidative stress mechanisms;
- Role of oxidative stress in metabolic syndrome and pregnancy disorders associated with obesity;
- Role of hypoxia in cardiovascular and renal programming: mechanisms and potential therapeutic targets with antioxidants;
- Effects of hypoxia on the programming of brain and blood–brain barrier antioxidant homeostasis;
- Epigenetic mechanisms involved in cardio-cerebral oxidative stress;
- Role of microRNAs in regulating cardiac HI injury in animal and clinical settings;
- Role of exercise and oxidative stress in hypoxia/hyperoxia cycle in hyperbaric oxygen therapy.
Dr. Rodrigo L. Castillo
Dr. Alejandro Gonzalez-Candia
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tissue hypoxia
- reperfusion injury
- hypoxic preconditioning
- oxidative stress
- antioxidants
- hypoxic programing
- microRNA
- clinical hypoxic settings
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