Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition

Dear Colleagues,

Hypoxic (HI) injury involves the worsening of organ dysfunction and cell death due to reduced blood flow, often caused by organ targeting or increased oxygen demand. While restoring blood flow is crucial to save ischemic tissues, reperfusion can cause additional damage, leading to reversible and irreversible changes in tissue and organ function. This is the basic pathophysiology of ischemia-reperfusion (IR) injury, particularly oxidative stress and cell death mechanisms. During reperfusion, local inflammation and oxidative stress increase, causing secondary injury. IR injury affects various organs, including the heart, lungs, kidneys, and brain, and neuroendocrine system, may induce systemic damage, potentially leading to multisystem organ and metabolic dysfunction. Similar responses occur in humans, especially in patients with acute and chronic hypoxia, intermittent hypoxia and hyperoxia expositions. Additionally, in certain cancers, like breast and colon, oxidative stress and hypoxia can lead to distant effects, such as cardio and lung toxicity. Finally, recent evidence suggests the implications of HI and oxidative stress in exercise preconditioning associated with Hyperbaric Oxygen Therapy (HBOT), and their clinical applications.

This Special Issue builds on the success of the First Edition, which features more than 10 interesting papers. In this Second Edition, we will continue to gather research articles and reviews that cover, but are not limited to, the following topics:

• Current concepts of pathophysiology and therapies in cardiac HI and pharmacological preconditioning;
• Current concepts of pathophysiology and therapies in HI signaling in skeletal muscle physiology;
• Current concepts of cancer therapy related-cardiac dysfunction in breast cancer and cancer survivors, oxidative stress mechanisms;
• Role of oxidative stress in metabolic syndrome and pregnancy disorders associated with obesity;
• Role of hypoxia in cardiovascular and renal programming: mechanisms and potential therapeutic targets with antioxidants;
• Effects of hypoxia on the programming of brain and blood–brain barrier antioxidant homeostasis;
• Epigenetic mechanisms involved in cardio-cerebral oxidative stress;
• Role of microRNAs in regulating cardiac HI injury in animal and clinical settings;
• Role of exercise and oxidative stress in hypoxia/hyperoxia cycle in hyperbaric oxygen therapy.

Dr. Rodrigo L. Castillo
Dr. Alejandro Gonzalez-Candia
Guest Editors

Manuscript Submission Information

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• tissue hypoxia
• reperfusion injury
• hypoxic preconditioning
• oxidative stress
• antioxidants
• hypoxic programing
• microRNA
• clinical hypoxic settings