Natural Products to Mitigate Oxidative Stress and Inflammation in Non-Communicable Intestinal Diseases

Dear Colleagues,

The incidence of non-communicable intestinal diseases is increasing worldwide and represents a significant burden for the healthcare sector. Among these, colorectal cancer and inflammatory bowel diseases (e.g., Crohn's disease and ulcerative colitis) stand out as pathologies with a significant impact on the quality of life of countless patients and, in the case of colorectal cancer, with high mortality rates. The onset of these pathologies is linked to genetic factors, but also to unhealthy dietary habits and alcohol or tobacco use, which contribute to oxidative and inflammatory events at the intestinal level. The treatment options currently available are often expensive, have severe side effects, and patients can develop resistance to treatment. For this reason, there is an urgent need to study the potential of dietary products to prevent the onset of these pathologies, or natural products that can be sources of nutraceuticals with antioxidant, anti-inflammatory, and anti-proliferative activity.

Therefore, this Special Issue aims to cover a selection of research papers and reviews that expand and deepen the knowledge of the potential of natural products as dietary antioxidant and anti-inflammatory agents or as sources of new lead compounds for the treatment and/or prevention of non-communicable intestinal diseases. We welcome studies reporting the action of natural compounds as novel anti-inflammatory, antioxidant, and anticancer agents, with emphasis on the mechanisms of action and molecular targets, evaluated using in vivo and in vitro methods.

Dr. Carlos Martins-Gomes
Prof. Dr. Amélia M. Silva
Guest Editors

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