Oxidative Stress and Inflammation in Neurologic Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 941

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Guest Editor
Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, No. 2-4, 400012 Cluj-Napoca, Romania
Interests: oxidative stress; nitrosative stress; inflammation; nanomedicine
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Special Issue Information

Dear Colleagues,

Oxidative stress/antioxidant balance and inflammation are major factors of neuronal death, which is the pathogenetic basis of many neurological diseases.

The physiopathological steps that must be followed to decipher the mechanisms of these diseases may be the key to innovative treatments in this field of research. From the pro-oxidant molecules, synthesized in excess, to the antioxidant ones, produced deficiently, there is a fragile line towards the initiation and maintenance of an inflammatory process. Activated pro-inflammatory cells, together with excessively produced pro-inflammatory cytokines, as well as matrix metalloproteinases, can contribute decisively to neuroinflammation, with important cellular or tissue damage consequences. Due to the complex function of the cells of the nervous system, the spectrum of neurological diseases produced by these pathogenetic mechanisms is extremely diverse.

This Special Issue is addressed to all researchers involved in deciphering the pathogenetic mechanisms of neurological diseases who wish to contribute to the development of targeted and personalized therapies in the field of neurological disorders associated with neuroinflammation. In this Special Issue, original research articles and reviews are welcome.

Prof. Dr. Adriana Bulboaca
Guest Editor

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Keywords

  • oxidative stress
  • nitrosative stress
  • neuroinflammation
  • neurodegeneration
  • neuronal apoptosis

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Published Papers (1 paper)

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Review

38 pages, 2174 KiB  
Review
Oxidative Stress: Pathological Driver in Chronic Neurodegenerative Diseases
by Zhao Zhong Chong and Nizar Souayah
Antioxidants 2025, 14(6), 696; https://doi.org/10.3390/antiox14060696 - 9 Jun 2025
Viewed by 679
Abstract
Oxidative stress has become a common impetus of various diseases, including neurodegenerative diseases. This review introduces the generation of reactive oxygen species (ROSs) in the nervous system, the cellular oxidative damage, and the high sensitivity of the brain to ROSs. The literature review [...] Read more.
Oxidative stress has become a common impetus of various diseases, including neurodegenerative diseases. This review introduces the generation of reactive oxygen species (ROSs) in the nervous system, the cellular oxidative damage, and the high sensitivity of the brain to ROSs. The literature review focuses on the roles of oxidative stress in neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Oxidative stress occurs when excessively produced free radicals are beyond the capability of endogenous antioxidants to scavenge, leading to the oxidation of proteins, lipids, and nucleic acids, stimulating neuroinflammatory responses, causing neuronal dysfunction, senescence, and death. The dysfunctional mitochondria and aberrant activities of metabolic enzymes are the major source of ROSs. The high vulnerability of the nervous system to ROSs underlies the critical roles of oxidative stress in neurodegenerative diseases. Gene mutations and other risk factors promote the generation of ROSs, which have been considered a crucial force causing the main pathological features of AD, PD, HD, and ALS. As a result, antioxidants hold therapeutic potential in these neurodegenerative diseases. The elucidation of the pathogenic mechanisms of oxidative stress will facilitate the development of antioxidants for the treatment of these diseases. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation in Neurologic Diseases)
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