Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
12.4
6.6
Journals
Antioxidants
Special Issues
Oxidative Stress from Environmental Exposures
share announcement

Oxidative Stress from Environmental Exposures

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 650

Special Issue Editors

Dr. Giulia Squillacioti

E-Mail Website
Guest Editor
Department of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy
Interests: oxidative stress; physical activity; body composition; respiratory health; environmental health; greenness; spatial analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Valeria Bellisario

E-Mail Website
Guest Editor
Department of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy
Interests: nutrition; health impact; public health; health literacy; innovative methodologies
Special Issues, Collections and Topics in MDPI journals
Dr. Federica Ghelli

E-Mail Website
Guest Editor Assistant
Department of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy
Interests: inflammation; oxidative stress; quality of life; health promotion; working context
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Environmental exposures refer to making contact or interacting with various agents, including exposure levels harmful to human health and well-being. Environmental exposures include both natural and man-made factors (e.g., air pollution, green spaces, toxics agents, etc.), and human health may be indirectly influenced via health-related lifestyles, like outdoor physical activity. These exposures have been linked to a range of health problems due to their ability to disrupt normal biological processes, often leading to inflammation, oxidative stress, and immune dysfunction. For instance, exposure to particulate matter can generate reactive oxygen species (ROS) in the body, overwhelming antioxidant defenses and causing damage to cells, tissues, and organs. Chronic exposure to these environmental stressors is associated with an increased risk of a wide variety of diseases.

This Special Issue aims to collate recent research on the association between environmental factors and oxidative stress/inflammatory status. We will examine their role as important factors involved in the pathogenesis of cardiovascular and neurodegenerative diseases, respiratory conditions, etc. Additionally, we are focused on potential biomarkers for assessing oxidative stress/inflammation as well as strategies to mitigate its harmful effects (i.e., antioxidants).

Overall, this collection emphasizes the importance of understanding the impacts of environmental exposures on health and analyzing oxidative stress/inflammation to offer insights into preventive and health-promoting strategies.

Dr. Giulia Squillacioti
Dr. Valeria Bellisario
Guest Editors

Dr. Federica Ghelli
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental exposures
  • human health
  • air pollution
  • lifestyle
  • oxidative stress
  • particulate matter
  • environmental stressors

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

19 pages, 2184 KiB  
Article
Molecular Alterations in Semen of Per-And Polyfluoroalkyl Substance Exposed Subjects: Association Between DNA Integrity, Antioxidant Capacity and Lipoperoxides
by Carmela Marinaro, Anna Rita Bianchi, Valeria Guerretti, Gaia Barricelli, Bruno Berman, Francesco Bertola, Salvatore Micali, Francesco Paolo Busardò, Alessandro Di Giorgi, Anna De Maio, Marina Piscopo, Luigi Montano and Gennaro Lettieri
Antioxidants 2025, 14(7), 792; https://doi.org/10.3390/antiox14070792 - 27 Jun 2025
Viewed by 468
Abstract
In the last decades, there has been huge interest in Per- and Polyfluoroalkyl Substances (PFAS) worldwide because of the toxic effects on humans. In 2013, a large-scale contamination of PFASs in the Veneto region was caused by a fluorochemical plant in Vicenza. About [...] Read more.
In the last decades, there has been huge interest in Per- and Polyfluoroalkyl Substances (PFAS) worldwide because of the toxic effects on humans. In 2013, a large-scale contamination of PFASs in the Veneto region was caused by a fluorochemical plant in Vicenza. About 130,000 inhabitants were exposed to PFAS in their drinking water. To date, relatively few studies have investigated the associations between blood serum PFAS concentrations and oxidative stress in semen. This study compared the antioxidant activity, lipoperoxide levels and protection or induction of oxidative DNA damage by sperm nuclear basic proteins (SNBP) in subjects living in Veneto exposed to PFAS (VNT) with those living in a non-PFAS contaminated area (VSL). Although the semen parameters were within the WHO range, the VNT semen samples showed higher levels of lipoperoxides and lower antioxidant activity compared to the VSL samples. These differences were statistically significant. We also examined DNA damage following SNBP addition under pro-oxidative conditions, finding a significantly different distribution of DNA damage types between the two groups, where 0 means no damage and 1 to 3 means increasing damage with 3 indicating maximum damage. SNBP of VNT subjects showed a reduced ability to protect DNA from oxidative damage. In the VSL group, damage 0 was found in 56% of subjects, 35% of the VNT group show damage 1, 36% damage 2 and 18% damage 3, while only 11% of VNT subjects show damage 0. Additionally, VNT with 0-grade DNA oxidative damage also exhibited reduced antioxidant activity and higher levels of lipoperoxides, in contrast to VSL. The results of this study indicate that exposure to PFAS produces oxidative stress in the semen of VNT subjects, who were also found to have blood serum perfluorooctanoic acid (PFOA) levels above the threshold. This suggests the possibility of infertility issues and emphasises the necessity for additional research into the long-term consequences of oxidative stress on male fertility and the health of offspring. Full article
(This article belongs to the Special Issue Oxidative Stress from Environmental Exposures)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop