Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

Dear Colleagues,

We are pleased to announce the launch of the Third Edition of the Special Issue ‘Role of Oxidative Stress in Cardiac Remodeling and Heart Failure’.

The field of cardiovascular research continues to rapidly evolve, with accumulating evidence underscoring the critical role of oxidative stress in the complex processes of cardiac remodeling and the pathogenesis of heart failure. Cardiac remodeling, defined as molecular, cellular, and interstitial cardiac changes that manifest clinically as changes in the size, shape, and function of the heart, remains a central feature in the progression towards heart failure. Cardiac failure is the final pathway of many cardiac diseases and presents a major public health issue due to its poor prognosis and high prevalence, morbidity, and mortality.

The intricate balance between the production and scavenging of reactive oxygen species (ROS) is fundamental to cardiac health. While physiological levels of ROS are involved in crucial intracellular signaling pathways, an imbalance leading to oxidative stress can trigger cellular damage, dysfunction, and ultimately cell death within the myocardium and systemically. The vicious cycle in which injured myocytes contribute to increased oxidative stress and further exacerbation of myocardial damage highlights the complexity and importance of this area of investigation. Despite considerable research efforts, a comprehensive understanding of the precise molecular mechanisms linking oxidative stress to heart failure remains an active and vital area of inquiry.

This Third Edition of our Special Issue aims to provide an updated comprehensive overview of the latest advancements in this critical field. We cordially invite you to contribute cutting-edge original research articles and insightful review papers encompassing in vitro studies, animal models, and clinical investigations that delve into the following key areas:

• Mechanisms underlying the role of increased oxidative stress in cardiac remodeling.
• The contribution of oxidative stress to the pathophysiology of various forms of heart failure.
• Novel biomarkers and diagnostic approaches related to oxidative stress in cardiac disease.
• Identification and validation of novel therapeutic targets aimed at mitigating oxidative stress in the context of cardiac remodeling and heart failure.
• Pharmacological and non-pharmacological interventions, including antioxidant therapies and lifestyle modifications, and their impact on cardiac remodeling and heart failure.
• The interplay between oxidative stress and other crucial pathways involved in heart failure, such as inflammation, fibrosis, and metabolic dysfunction.
• Translational research bridging basic science discoveries to clinical applications in the management of heart failure.

We believe that this Special Issue will serve as a valuable resource for researchers and clinicians, fostering a deeper understanding of the intricate role of oxidative stress in cardiac disease and paving the way for the development of innovative diagnostic and therapeutic strategies.

We look forward to receiving your significant contributions to this timely and important topic.

Dr. Marina Politi Okoshi
Dr. Elida Paula Benquique Ojopi
Dr. Luana Urbano Pagan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• heart disease
• cardiac remodeling
• signaling pathways
• remodeling
• left ventricular dysfunction
• heart failure
• cardiovascular disease
• myocardial damage