Hydrogen Sulfide, Reactive Sulfur Species, and Donor Compounds: Natural and Synthetic Tools for Physiology and Disease

Dear Colleagues,

Hydrogen sulfide (H₂S) is now widely acknowledged as the third endogenous gasotransmitter, joining nitric oxide (NO) and carbon monoxide (CO) as a key regulator of diverse biological processes. It influences numerous physiological systems, including vascular regulation, immune responses, redox balance, and mitochondrial function. Despite its important roles, the full characterization of H₂S signaling is limited because of its low endogenous concentrations and rapid reactivity within biological systems. To overcome these challenges and to better define the physio-pathological functions of this gas, natural sources of H₂S have been used, and significant efforts have been directed toward the development of synthetic H₂S sources. In particular, the design of H₂S-donor compounds—capable of releasing the gas in a controlled and physiologically relevant manner—has become an essential strategy for elucidating its functions and therapeutic potential.

We invite you to submit your latest research findings or review articles to this Special Issue, as we aim to gather cutting-edge research focused on the chemistry, biology, and pharmacology of H₂S and its donors. This Special Issue offers a multidisciplinary platform for advancing our understanding of sulfur-based signaling in both physiological and pathological contexts, highlighting novel pharmacological tools and mechanistic insights.

We look forward to your valuable contributions.

Prof. Dr. Giuseppe Caliendo
Dr. Angela Corvino
Guest Editors

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