Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Cancer

Dear Colleagues,

Vitamin C is a very well-known water-soluble vitamin that acts as an antioxidant in physiological concentrations. Among others, it is also involved in collagen formation, the synthesis of neurotransmitters, and tissue repair. Unlike most animals, it cannot be synthesized by humans and is accordingly an essential micronutrient.

Cancer patients in advanced stages often show very low, sometimes almost scurvy-like, vitamin C plasma levels, and studies are accumulating that indicate the efficacy of parenteral high-dose vitamin C in the context of the therapy of various tumor entities. This Special Issue will now critically review the suitability of vitamin C in both tumor prevention and tumor therapy. Any original papers, review articles, or short communications that help clarify the possible advantages and disadvantages of vitamin C in this context, whether by elucidating the underlying mechanisms or efficacy in vitro, in vivo, or in clinical trials, are welcome.

Dr. Luigi Marongiu
Dr. Olga Renner
Dr. Markus Burkard
Prof. Dr. Sascha Venturelli
Guest Editors

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