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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 16 Feb 2026 | 5 articles | Viewed by 13450

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)

edited by

Anna Kakehashi

and Min Gi

submission deadline 18 Feb 2026 | 2 articles | Viewed by 13014 | Submission Open

Keywords: cancer; screening; diagnosis; anti-cancer; drugs; mechanisms of carcinogenesis; chemopreventive agents

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Cancers

edited by

Sudhir Rai

and

Seema Kumari

submission deadline 20 Feb 2026 | 3 articles | Viewed by 13629 | Submission Open

Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins

(This special issue belongs to the Section Tumor Microenvironment)

Gaps in Cancer Cachexia Research

edited by Jose M. Garcia and

Lindsey J. Anderson

submission deadline 20 Feb 2026 | 3 articles | Viewed by 12068 | Submission Open

Keywords: cancer cachexia; physical function; innovative models; rehabilitation; patient-reported outcomes; gender; aging; skeletal muscle; brain; adipose tissue

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Quality of Life and Side Effects Management in Cancer Treatment (3rd Edition)

edited by

António Araújo

submission deadline 20 Feb 2026 | 4 articles | Viewed by 11571 | Submission Open

Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Ultrasonography for Pancreatobiliary Cancer

edited by

Yasunobu Yamashita

submission deadline 20 Feb 2026 | 3 articles | Viewed by 6915 | Submission Open

Keywords: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management: 2nd Edition

edited by

Juan Manuel Rosa-Rosa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4629 | Submission Open

Keywords: multiple myeloma (MM); hematologic malignancies; next-generation sequencing; heterogeneous disease; tumor heterogeneity; genomic landscape; outcomes; novel treatments; clinical trial

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Biomarkers and Clinical Translation: 2nd Edition

edited by

Cristian Scatena

and Carmine De Angelis

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3715 | Submission Open

Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy

(This special issue belongs to the Section Cancer Biomarkers)

Advanced Surgical Modalities in Breast Cancer Treatment

edited by Jan Žatecký

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2374 | Submission Open

Keywords: breast cancer surgery; breast cancer localization; breast conserving surgery; mastectomy; oncoplastic surgery; axillary lymph node staging; sentinel lymph node biopsy; targeted axillary dissection

(This special issue belongs to the Section Clinical Research of Cancer)

AI-Driven Predictive Modeling in Radiation Therapy: Toward Precision and Personalized Clinical Applications

edited by

Yujie Huang

submission deadline 20 Feb 2026 | Viewed by 376 | Submission Open

Keywords: AI-based radiotherapy; predictive modeling in oncology; personalized radiation therapy; radiomics and dosiomics; adaptive radiotherapy; treatment outcome prediction; explainable AI in medicine; multimodal data integration; clinical decision support systems; precision cancer treatment

Fibroblasts as Playmakers of Cancer Progression: Current Knowledge and Future Perspectives (2nd Edition)

edited by

Kenichiro Ishii

submission deadline 20 Feb 2026 | Viewed by 357 | Submission Open

Keywords: tumor microenvironment; reactive stroma; fibroblasts; cancer progression; heterotypic interactions between cancer cells and fibroblasts; reactive stroma-targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy: 2nd Edition

edited by

Claudia Paret

submission deadline 20 Feb 2026 | Viewed by 278 | Submission Open

Keywords: targeted therapy; drug repositioning; biomarkers; basket trials; precision oncology; personalized medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Minimal Residual Disease in Solid Tumors: Emerging Technologies and Clinical Applications

edited by

Sofia Agelaki

Kleita Michaelidou

and Aristeidis Boukouris

submission deadline 25 Feb 2026 | Viewed by 304 | Submission Open

Keywords: minimal residual disease (MRD); solid tumors; circulating tumor DNA (ctDNA); liquid biopsy; tumor-informed assays; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Harnessing the Gut Microbiome to Improve Colorectal Cancer Outcomes

edited by Carole S. Richard

submission deadline 25 Feb 2026 | Viewed by 282 | Submission Open

Keywords: colorectal cancer (CRC); gut microbiome; screening; CRC cells; the gut microenvironment; oncological outcomes

(This special issue belongs to the Section Infectious Agents and Cancer)

Radiation Therapy for Modern Management of Bone Metastases (2nd Edition)

edited by

Francesco Cellini

submission deadline 25 Feb 2026 | Viewed by 257 | Submission Open

Keywords: radiotherapy; palliative care; steretactic radiotherapy; SBRT; immunotherapy; chemotherapy; oligometastases

(This special issue belongs to the Section Cancer Therapy)

Advances in the Treatment of Gastrointestinal (GI) Cancers

edited by

Yoshiyasu Kono

submission deadline 27 Feb 2026 | 2 articles | Viewed by 1911 | Submission Open

Keywords: gastrointestinal cancers; targeted therapy; immunotherapy; precision oncology; biomarkers; molecular mechanisms; tumor microenvironment; resistance to therapy; translational research; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Updates in Renal Cell Carcinoma (2nd Edition)

edited by

Irbaz B Riaz

submission deadline 27 Feb 2026 | Viewed by 193 | Submission Open

Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 28 Feb 2026 | 6 articles | Viewed by 21043 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

State of the Art and Novelties in Multidisciplinary Approach to Soft Tissue and Bone Sarcomas

edited by Ron Batash, Alberto Crimì, Moshe Schaffer and

Pietro Ruggieri

submission deadline 28 Feb 2026 | 7 articles | Viewed by 19752 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; treatment; diagnosis; radiation therapy; chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Challenges and Opportunities for Novel Therapeutic Strategies in Pediatric Oncology

edited by

Jeong A Park

and

Jaume Mora

submission deadline 28 Feb 2026 | 7 articles | Viewed by 18903 | Submission Open

Keywords: antibody-drug conjugate; bispecific antibody; cancer predisposition; CAR T cell; immunotherapy; leukemia; monoclonal antibody; neuroblastoma; pediatric cancer; photoimmunotherapy; precision medicine; sarcoma; translational research; tyrosine kinase inhibitor

(This special issue belongs to the Section Cancer Therapy)

Advances in Bladder Preservation Approaches for Bladder Cancer (2nd Edition)

edited by

Jay J. Liao

and Todd A. Yezefski

submission deadline 28 Feb 2026 | 5 articles | Viewed by 17609 | Submission Open

Keywords: bladder cancer; bladder preservation; trimodality therapy; chemoradiation; immunotherapy; intravesical therapy; BCG refractory or unresponsive

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Oncological Imaging (2nd Edition)

edited by

Michaela Cellina

and

Maurizio Cè

submission deadline 28 Feb 2026 | 5 articles | Viewed by 12069 | Submission Open

Keywords: oncological imaging; radiomics; deep learning; machine learning; image reconstruction; artificial intelligence; outcome prediction; oncological treatment planning; advanced imaging; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into General, Functional and Oncologic Urology

edited by Kajetan Juszczak and

Przemysław Adamczyk

submission deadline 28 Feb 2026 | 5 articles | Viewed by 11896 | Submission Open

Keywords: basic science; experimental models; urological cancer; management innovations; multidisciplinary approaches; treatment outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends

edited by

Federica Martorana

and Giacomo Barchiesi

submission deadline 28 Feb 2026 | 3 articles | Viewed by 10749 | Submission Open

Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Improving Surgical Care for Patients with Hepatobiliary and Pancreatic Cancers

edited by Christopher B. Nahm and Kai M. Brown

submission deadline 28 Feb 2026 | 4 articles | Viewed by 9386 | Submission Open

Keywords: hepatobiliary; pancreatic; surgery; biomarkers; prognosis; treatment strategy

(This special issue belongs to the Section Cancer Therapy)

3D Cultures and Organoids in Cancer Research

edited by

Karla Rubio

and

César López-Camarillo

submission deadline 28 Feb 2026 | 3 articles | Viewed by 8806 | Submission Open

Keywords: 3D cell cultures; organotypic 3D cultures; 3D spheroids models; induced pluripotent stem (iPS); organoids; tumoroids

(This special issue belongs to the Section Molecular Cancer Biology)

Diagnosis, Staging, and Management for Gynecologic Oncology

edited by

Malgorzata Klimek

submission deadline 28 Feb 2026 | 1 articles | Viewed by 8331 | Submission Open

Keywords: gynecologic oncology; cancer biology; HPV infection; molecular risk factors; translational medicine; cancer staging systems; radiation therapy; brachytherapy; radioresistance

(This special issue belongs to the Section Cancer Therapy)

Regulators of Breast Cancer Metastasis

edited by

Terumi Kohwi-Shigematsu

and

Saori Furuta

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7590 | Submission Open

Keywords: tumor progression regulators; metastasis; tumor microenvironment; biomarkers for recurrence; transcriptional regulation; chromatin structure; epigenetics; cancer metabolism; cancer immunity; microbiome

(This special issue belongs to the Section Cancer Metastasis)

Personalized Radiotherapy in Cancer Care (2nd Edition)

edited by

Bin S. Teh

and

Waqar M. Haque

submission deadline 28 Feb 2026 | 4 articles | Viewed by 7210 | Submission Open

Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy

(This special issue belongs to the Section Methods and Technologies Development)

Exploring Non-Coding RNA Signatures in Cancer: Definitions and Implications for Diagnosis and Therapy

edited by

Amog Urs

and Udhayakumar Gopal

submission deadline 28 Feb 2026 | 5 articles | Viewed by 6685 | Submission Open

Keywords: non-coding RNA; biomarkers; gene regulation; microRNA; long non-coding RNA; circular RNA; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Clinical Feature, Trial and Management

edited by

Roberto Tozzi

Marco Noventa

and Carlo Saccardi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6615 | Submission Open

Keywords: cervical cancer; diagnosis; minimally invasive surgery; laparoscopy; locally advanced disease; management; treatment; adjuvant chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Perioperative Care in Gynecologic Oncology: 2nd Edition

edited by Nikolaos Thomakos and

Vasilios Pergialiotis

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6263 | Submission Open

Keywords: enhanced recovery; ERAS; immunonutrition; prehabilitation; gynecologic oncology; minimally invasive surgery

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immunoediting in Cancer Therapies

edited by

Vijay Kumar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 4131 | Submission Open

Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3193 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3014 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2788 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2780 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Advancements in Technologies for Radiation Biology, Oncology, and Protection

edited by

Zhixiang Wang

and

Yi Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2660 | Submission Open

Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine

(This special issue belongs to the Section Cancer Informatics and Big Data)

Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2573 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2400 | Submission Open

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Predictive and Prognostic Biomarkers for Response to Neoadjuvant Chemotherapy for Breast Cancer

edited by Tarek M. A. Abdel-Fatah

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2050 | Submission Open

Keywords: breast cancer; predictive and prognostic biomarkers; neoadjuvant chemotherapy; HER2-targeting agents; complete pathological response

(This special issue belongs to the Section Cancer Therapy)

Novel Approaches to Machine Learning and Artificial Intelligence in Cancer Research and Care (2nd Edition)

edited by

Caroline Chung

and Chris J. Gibbons

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2007 | Submission Open

Keywords: machine learning; deep learning; artificial intelligence; interpretable AI; data quality; metadata; data quality; cancer; MLOps; data science; real-world data

(This special issue belongs to the Section Cancer Informatics and Big Data)

MRI and Artificial Intelligence in Oncology: Current Research and Future Directions

edited by

Amita Shukla-Dave

and

Ramesh Paudyal

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1929 | Submission Open

Keywords: MRI; AI; radiology; oncology; clinical trials

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Research and Prognosis of HER2-Positive Breast Cancer

edited by

Pierfranco Conte

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1730 | Submission Open

Keywords: HER2-positive breast cancer; targeted therapy; anti-HER2 therapy; long-term impacts; prognostic

(This special issue belongs to the Section Clinical Research of Cancer)

Lung Cancer—Advances in Therapy and Prognostic Prediction

edited by Chinmay T. Jani and Estelamari Rodríguez

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1643 | Submission Open

Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Choroidal Melanoma: From Treatment to Prognosis

edited by

Giovanni Paolino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: melanoma; uveal; choroid; treatments; target; immunotherapy; genetics

(This special issue belongs to the Section Molecular Cancer Biology)

Risk of Skin Cancer: Non-Melanoma/Melanoma

edited by

Eggert Stockfleth

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Precision Health Care and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome (2nd Edition)

edited by

Maria C. Katapodi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1059 | Submission Open

Keywords: breast cancer; ovarian Cancer; lynch Syndrome; precision healthcare

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Image-Assisted High-Precision Radiation Oncology

edited by He C. Wang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 938 | Submission Open

Keywords: medical imaging; radiation oncology; artificial intelligence; radiomics; adaptation; tumor response

(This special issue belongs to the Section Cancer Therapy)

Mechanistic Insights and Therapeutic Advances in the Prostate Tumor Microenvironment

edited by Omar E. Franco

submission deadline 28 Feb 2026 | 1 articles | Viewed by 870 | Submission Open

Keywords: prostate stromal cells; tumor microenvironment; stromal– epithelial interactions; extracellular matrix; tumor immune evasion; metabolic reprogramming; hypoxia; single-cell data analysis; in vitro/in vivo model systems; carcinoma-associated fibroblasts (CAFs)

(This special issue belongs to the Section Tumor Microenvironment)

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