Cell Therapy in Hematological Malignancies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1093

Special Issue Editors


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Guest Editor
Department of Medicine and Surgery, LUM University “Giuseppe Degennaro”, Casamassima, 70124 Bari, Italy
Interests: lymphoma; hematological disease; stem cell transplantation; immunotherapy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Medicine and Surgery, LUM University “Giuseppe Degennaro”, Casamassima, 70124 Bari, Italy
Interests: experimental medicine; oncology; molecular and clinical pathology; predictive medicine; clinical molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Traditionally, the treatment of hematological malignancies mainly included chemotherapy, radiotherapy, and hematopoietic stem cell transplantation (HSCT). However, with advances in tumor immunology, immune targeted therapy, such as monoclonal antibodies, bispecific antibodies, antibody–drug conjugates, and chimeric antigen receptor T (CAR-T) cell therapy, has opened a new avenue for the treatment of malignancies.

Thus, the aim of this Special Issue is to present analyses of biological approaches in the treatment of lymphomas, with particular emphasis on immunological implications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Immunotherapies, adjuvants and immunomodulators;
  • Cell therapy developments and mechanisms of action;
  • Immunology mechanisms;
  • Immune response to immunotherapies.

We look forward to receiving your contributions.

Dr. Francesco Gaudio
Dr. Stefano Martinotti
Guest Editors

Manuscript Submission Information

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Keywords

  • cell therapy
  • immunotherapy
  • target therapy
  • hematological malignancies
  • tumor immunology

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Published Papers (1 paper)

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21 pages, 1828 KiB  
Systematic Review
Exploring the Role of Epithelial–Mesenchymal Transcriptional Factors Involved in Hematological Malignancy and Solid Tumors: A Systematic Review
by Rimsha Kanwal, Jessica Elisabetta Esposito, Bilal Jawed, Syed Khuram Zakir, Riccardo Pulcini, Riccardo Martinotti, Matteo Botteghi, Francesco Gaudio, Stefano Martinotti and Elena Toniato
Cancers 2025, 17(3), 529; https://doi.org/10.3390/cancers17030529 - 5 Feb 2025
Viewed by 827
Abstract
Background: The epithelial mesenchymal transition (EMT) is a biological process in which epithelial cells lose their polarity and adhesion characteristics, and adopt a mesenchymal phenotype. While the EMT naturally occurs during tissue fibrosis, wound healing, and embryonic development, it can be exploited by [...] Read more.
Background: The epithelial mesenchymal transition (EMT) is a biological process in which epithelial cells lose their polarity and adhesion characteristics, and adopt a mesenchymal phenotype. While the EMT naturally occurs during tissue fibrosis, wound healing, and embryonic development, it can be exploited by cancer cells and is strongly associated with cancer stem cell formation, tissue invasiveness, apoptosis, and therapy resistance. Transcription factors (TFs) such as SNAIL, ZEB, and TWIST play a pivotal role in driving the EMT. This systematic review aims to assess the impact of EMT-TFs on hematological malignancy and solid tumors. Methods: English-language literature published between 2010 and 2024 was systematically reviewed, utilizing databases such as PubMed and Google Scholar. Results: A total of 3250 studies were extracted. Of these, 92 publications meeting the inclusion criteria were analyzed to elucidate the role of EMT-TFs in cancer. The results demonstrated that the EMT-TFs play a critical role in both hematological and solid tumor development and progression. They promote invasive, migratory, and metastatic properties in these tumors, and contribute to therapeutic challenges by enhancing chemoresistance. A strong correlation between EMT-TFs and poor overall survival has been identified. Conclusions: Our research concluded that EMT-TFs may serve as important predictive and prognostic factors, as well as potential therapeutic targets to mitigate cancer progression. Full article
(This article belongs to the Special Issue Cell Therapy in Hematological Malignancies)
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