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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Signaling Pathways of Breast Cancer

edited by

Sandra Casimiro

and

Marta Martins

submission deadline 30 May 2025 | 2 articles | Viewed by 7020 | Submission Open

Keywords: Breast cancer; signal transduction; targeted therapies; resistance to therapy; novel molecular mechanisms

(This special issue belongs to the Section Tumor Microenvironment)

Melanoma: Clinical Trials and Translational Research

edited by Roberta Giuffrida,

Claudio Guarneri

, Linda Tognetti and

Claudio Conforti

submission deadline 30 May 2025 | 3 articles | Viewed by 5084 | Submission Open

Keywords: melanoma; skin cancer; biomarkers; genomics; diagnosis; therapy; immunotherapy; targeted therapy; resistance

(This special issue belongs to the Section Clinical Research of Cancer)

New Advances in Urothelial Cancer: Diagnosis, Therapy and Prognosis (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 30 May 2025 | 3 articles | Viewed by 3454 | Submission Open

Keywords: liquid biopsy; robotic surgery; device-assisted therapy; immunotherapy; PDL-1 inhibitors; urinary tumor DNA; bladder cancer; upper urinary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Mass Spectrometry-Based “Omics” Approaches in Cancer Research

edited by

Rita Casadonte

and

Kristina Schwamborn

submission deadline 30 May 2025 | 1 articles | Viewed by 3392 | Submission Open

Keywords: biomarker discovery; cancer; mass spectrometry; “ omics”

(This special issue belongs to the Section Methods and Technologies Development)

Progress in the Systemic Therapy of Urological Oncology

edited by Anna Patrikidou

submission deadline 30 May 2025 | 1 articles | Viewed by 2497 | Submission Open

Keywords: systemic therapy; urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

Effects of Radiotherapy on the Tumor Microenvironment

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 30 May 2025 | Viewed by 393 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma

(This special issue belongs to the Section Tumor Microenvironment)

Management of Recurrent Endometrial Cancer

edited by Jayanta Chatterjee, Alexandra Stewart, Hersha Patel and

Emmanouil Karteris

submission deadline 30 May 2025 | Viewed by 381 | Submission Open

Keywords: recurrence patterns; molecular markers; staging; risk prediction; treatment failure; mortality from endometrial cancer

(This special issue belongs to the Section Cancer Therapy)

Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments

edited by

Alessandro Fancellu

submission deadline 30 May 2025 | Viewed by 339 | Submission Open

Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging

(This special issue belongs to the Section Cancer Therapy)

Current Advances in Management of Neuroendocrine Neoplasms

edited by Ashley Kieran Clift and

Andrea Frilling

submission deadline 30 May 2025 | Viewed by 251 | Submission Open

Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management of Patients with Melanoma and Brain Metastases

edited by Malaka Ameratunga

submission deadline 30 May 2025 | Viewed by 232 | Submission Open

Keywords: brain neoplasms/secondary; brain neoplasms/therapy; central nervous system neoplasms; melanoma; humans; skin neoplasms

(This special issue belongs to the Section Cancer Therapy)

Molecular Insights into Drug Resistance in Cancer

edited by Yuqi Yang

submission deadline 31 May 2025 | 15 articles | Viewed by 52874 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

(This special issue belongs to the Section Molecular Cancer Biology)

PI3K Pathway in Cancer

edited by

Navid Sobhani

and

Gabriella Nesi

submission deadline 31 May 2025 | 4 articles | Viewed by 17929 | Submission Open

Keywords: PI3K; AKT; mTOR; PI3KCA mutations; targeted therapies; biomarkers; everolimus; temsirolimus; copanlisib and idelalisib; alpelisib; immunology

(This special issue belongs to the Section Cancer Therapy)

New Insights of Hematology in Cancer

edited by

Nicoletta Coccaro

submission deadline 31 May 2025 | 11 articles | Viewed by 15820 | Submission Open

Keywords: hematologic neoplasms; cancer genetics; molecular target; precision medicine; target therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Contemporary Diagnosis and Management of Prostate Cancer

edited by Thomas Jang

submission deadline 31 May 2025 | 8 articles | Viewed by 15644 | Submission Open

Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 31 May 2025 | 6 articles | Viewed by 11544 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

Novel Experimental Therapeutic Targets and Strategies for Brain Tumors

edited by

Yunqing Li

and

Roger Abounader

submission deadline 31 May 2025 | 5 articles | Viewed by 11428 | Submission Open

Keywords: brain tumors; glioma; glioblastoma; medulloblastoma; radiotherapy; chemotherapy; immunotherapy; combination therapy; microRNAs; oncogene signaling pathways; epigenetic regulation; metabolic regulation; nanotechnology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Advances in Pediatric and Adolescent Psycho-Oncology

edited by

Lori Wiener

and Amanda L. Thompson

submission deadline 31 May 2025 | 11 articles | Viewed by 11111 | Submission Open

Keywords: childhood cancer; adolescents; young adult; psychosocial care; emotional outcomes; survivorship; palliative care; bereavement

(This special issue belongs to the Section Pediatric Oncology)

Drug Delivery for Cancer Therapy

edited by

Swayam Prabha

submission deadline 31 May 2025 | 4 articles | Viewed by 8366 | Submission Open

Keywords: drug delivery; adverse effects; targeting; non-specific distribution; stromal cells; stroma modulation; tumor microenvironment; transport barriers; nanomedicine

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer: Imaging and Radiotherapy

edited by

Fabio Sandomenico

submission deadline 31 May 2025 | 3 articles | Viewed by 8348 | Submission Open

Keywords: skin cancer; imaging technology; radiotherapy; cancer diagnosis; medical imaging

(This special issue belongs to the Section Methods and Technologies Development)

Head and Neck Cancer: Advanced PET/CT and MRI Imaging with a Focus on Current and Emerging Molecular Theranostics

edited by Bennett Chin, Jorge Oldan and Steven P. Rowe

submission deadline 31 May 2025 | 4 articles | Viewed by 8277 | Submission Open

Keywords: head and neck cancer; thyroid cancer; PET/SPECT/CT molecular imaging; radionuclide therapy; nuclear medicine

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment

edited by

Takuji Okusaka

submission deadline 31 May 2025 | 5 articles | Viewed by 8205 | Submission Open

Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care

(This special issue belongs to the Section Clinical Research of Cancer)

Lymph Node Dissection for Gynecologic Cancers

edited by

Fabio Landoni

submission deadline 31 May 2025 | 3 articles | Viewed by 6301 | Submission Open

(This special issue belongs to the Section Methods and Technologies Development)

Bridging the Gap: Integrating AI into Clinical Practice for Oncological PET/CT Imaging

edited by Fereshteh Yousefirizi

submission deadline 31 May 2025 | 4 articles | Viewed by 4786 | Submission Open

Keywords: physician-in-the-loop; PET/CT; AI; foundation model; generalist model; tumor segmentation; outcome prediction; whole-body PET; cancers

(This special issue belongs to the Section Cancer Therapy)

Cell-Free DNA as Prognostic and Predictive Biomarker in Solid Cancers (2nd Edition)

edited by

Edoardo Francini

Pier Vitale Nuzzo

and

Giuseppe Fanelli

submission deadline 31 May 2025 | 2 articles | Viewed by 3619 | Submission Open

Keywords: cell-free DNA; cfDNA; solid tumors; predictive biomarkers; prognostic biomarkers; precision medicine; treatment personalization

(This special issue belongs to the Section Cancer Biomarkers)

Cell Adhesion in Human Cancer

edited by

Takashi Kojima

, Makoto Osanai and

Akira Ikari

submission deadline 31 May 2025 | 2 articles | Viewed by 2629 | Submission Open

Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements in Bladder Cancer Therapy

edited by

Jørgen Jensen

submission deadline 31 May 2025 | 3 articles | Viewed by 2135 | Submission Open

Keywords: diagnostic; molecular markers; treatment; instillation therapy; systemic therapy; bladder sparring protocols

(This special issue belongs to the Section Cancer Therapy)

The Neoadjuvant Therapy for Breast Cancer

edited by Marcus Vetter and

Cvetka Grašič-Kuhar

submission deadline 31 May 2025 | 1 articles | Viewed by 2099 | Submission Open

Keywords: breast cancer; neoadjuvant treatment; innovative therapy; outcome studies; molecular treatments

(This special issue belongs to the Section Cancer Therapy)

The Impact of Community Context and Cancer Disparities

edited by Briseis Aschebrook-Kilfoy and Jiajun Luo

submission deadline 31 May 2025 | 1 articles | Viewed by 1574 | Submission Open

Keywords: community; contextual factors; neighborhood; social determinants; networks; social integration; social support; discrimination stressors; engagement; residence

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances and Research Priorities for Metastatic-Hormone-Resistant Prostate Cancer

edited by Bassel Nazha

submission deadline 31 May 2025 | 1 articles | Viewed by 1528 | Submission Open

Keywords: prostate cancer; combination therapy; precision oncology; ctDNA; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 31 May 2025 | 1 articles | Viewed by 1219 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition

edited by

Antonio Piñero-Madrona

submission deadline 31 May 2025 | 2 articles | Viewed by 1189 | Submission Open

Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery

(This special issue belongs to the Section Cancer Therapy)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 31 May 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Imaging-Guided Interventional Cancer Combination Immunotherapy

edited by

Zhuoli Zhang

submission deadline 31 May 2025 | 1 articles | Viewed by 988 | Submission Open

Keywords: image-guided cancer immunotherapy; image-guided combination therapies; local ablation; targeted immunotherapy; the assessment of therapeutic response

(This special issue belongs to the Section Methods and Technologies Development)

Diagnoses and Treatments of Metastatic Endometrial Cancer

edited by

Wenxin Zheng

submission deadline 31 May 2025 | 1 articles | Viewed by 954 | Submission Open

Keywords: endometrial cancer; mesonephric-like adenocarcinoma; pilomatrix-like high-grade endometrioid carcinomas; endometrial carcinosarcomas showing different prognosis based on different epithelial and mesenchymal components; pathologic diagnosis; imaging studies; target therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Updates on Breast Cancer Interventional and Diagnostic Imaging

edited by Jacopo Nori

submission deadline 31 May 2025 | 1 articles | Viewed by 839 | Submission Open

Keywords: breast cancer screening; digital breast tomosynthesis (DBT); MRI; genetic screening; risk assessment models; artificial intelligence (AI); contrast-enhanced mammography; dense breast tissue; screening guidelines; overdiagnosis and overtreatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Symptom Control and Palliative Care in Cancer

edited by

Sriram Yennurajalingam

submission deadline 31 May 2025 | 1 articles | Viewed by 692 | Submission Open

Keywords: palliative care; survivorship; cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Genetic and Epigenetic Heterogeneity in Cancer

edited by

Liang Liu

submission deadline 31 May 2025 | Viewed by 534 | Submission Open

Keywords: genetics; epigenetics; cancer heterogeneity; cancer diagnosis; cancer treatment

(This special issue belongs to the Section Molecular Cancer Biology)

Surgery for Cervical Cancer

edited by Jiantai Timothy Qiu

submission deadline 31 May 2025 | Viewed by 372 | Submission Open

Keywords: cervical cancer; surgical approaches; surgical interventions; adjutant therapies

(This special issue belongs to the Section Cancer Therapy)

Advances in Vulvar Cancer

edited by

Natalia Rakislova

and

Jaume Ordi

submission deadline 31 May 2025 | Viewed by 336 | Submission Open

Keywords: vulvar squamous cell carcinoma (VSCC); HPV; p53; molecular characteristics; diagnosis; therapeutic approaches; prognostic biomarkers

(This special issue belongs to the Section Clinical Research of Cancer)

Perioperative and Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer

edited by Martin Frueh and Kira-Lee Koster

submission deadline 31 May 2025 | 1 articles | Viewed by 294 | Submission Open

Keywords: neoadjuvant immunotherapy; perioperative immunotherapy; pathological response

(This special issue belongs to the Section Clinical Research of Cancer)

The Cancer Stem Cells and the Quiescence

edited by

Bhopal Mohapatra

submission deadline 31 May 2025 | Viewed by 275 | Submission Open

Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Oncogenic Driver Mutations and Signaling Pathways in Tumorigenesis and Therapy in Lung Cancer

edited by

Lei Duan

submission deadline 31 May 2025 | Viewed by 266 | Submission Open

Keywords: lung cancer; oncogenic driver mutations; signaling pathways; tumorigenesis; therapy; precision medicine; targeted therapy; biomarkers; resistance mechanisms; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

New Insights into Oligo-Recurrence of Various Cancers (2nd Edition)

edited by

Tadahiko Shien

submission deadline 31 May 2025 | Viewed by 233 | Submission Open

Keywords: oligo-recurrence; diagnostic imaging; systemic therapy; local therapy; controlled primary tumor; regional lymph nodes; distant metastasis

(This special issue belongs to the Section Cancer Therapy)

Therapeutic Optimization of Anti-tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2025 | Viewed by 218 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

New Insights in the Role of Myeloid-Derived Suppressor Cells (MDSCs) in Cancer

edited by Rita Campanelli

submission deadline 31 May 2025 | Viewed by 208 | Submission Open

Keywords: myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2025 | 6 articles | Viewed by 9956 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Diversity of Gliomas: Epidemiology, Pathology and Genetic/Epigenetic Heterogeneity

edited by

Maria-Magdalena Georgescu

submission deadline 1 Jun 2025 | 1 articles | Viewed by 2993 | Submission Open

Keywords: glioma molecular heterogeneity; glioblastoma demographics; glioma spatiotemporal evolution; glioma genomics; glioma epigenomics; glioma pathology; animal and organoid models of glioma heterogeneity

(This special issue belongs to the Section Cancer Pathophysiology)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2025 | 2 articles | Viewed by 1537 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Breast Cancer Metastasis: Novel Insights into Molecular Mechanisms and Treatments

edited by

Delphine Denoyer

submission deadline 5 Jun 2025 | 7 articles | Viewed by 15253 | Submission Open

Keywords: breast cancer; metastasis; organ-specific metastasis; cellular and molecular mechanisms; biomarkers; response to treatments; small-molecule inhibitors; immunotherapy; tumor dormancy

(This special issue belongs to the Section Cancer Metastasis)

Photodynamic Therapy for Cancers: An Update

edited by

Jiro Akimoto

submission deadline 6 Jun 2025 | Viewed by 266 | Submission Open

Keywords: photodynamic therapy; photosensitizer; cancer therapy; laser; reactive oxygen species; apoptosis; optical fiber

(This special issue belongs to the Section Cancer Therapy)

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