State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 37
Special Issue Editor
Interests: plasma cell disorders; multiple myeloma; amyloidosis; plasma cell leukemia; CAR-T
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue, titled “State-of-the-Art Research on Multiple Myeloma Progression” (https://www.mdpi.com/journal/cancers/special_issues/643D1E11VE).
Multiple myeloma is a type of blood cancer that occurs when malignant plasma cells accumulate in the bone marrow. In recent years, scientists have made significant progress in understanding the molecular pathways involved in myeloma development and in developing new drugs to treat this disease.
One crucial area of research has been the identification of genetic mutations and alterations that contribute to the development of myeloma. In addition, by studying the genomic landscape of myeloma, researchers have discovered new targets for drug development, such as inhibitors of the oncogene, including MYC, MDM2, IRF4, and PERK.
Another area of focus has been the development of immunotherapies, which harness the immune system's power to fight cancer. One promising approach involves the use of chimeric antigen receptor (CAR) T-cell or chimeric NK-cell therapy, which involves genetically engineering a donor's or patient's immune cells to recognize and attack myeloma cells, and developing off-the-shelf bispecific T-cell engagers against multiple targets, such as BCMA, GPRC5D, FcRH5, and the cluster of differentiation (CD)1d and CD47. In addition, T-cell engager underdevelopment could be employed to affect multiple targets simultaneously.
Bench-to-bedside development is a vital process that enables the development of new therapies for myeloma, leading to improved patient outcomes and survival. Current state-of-the-art therapies in myeloma include immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, T-cell engagers, CAR-T cell therapies, and XPO-1 inhibitors.
Recent advances in myeloma research and drug development are offering hope and the possibility of improved outcomes to patients with this challenging disease.
Dr. Shebli Atrash
Guest Editor
Manuscript Submission Information
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Keywords
- multiple myeloma
- novel targets
- novel therapies
- molecular therapy
- immunotherapy
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Related Special Issue
- State-of-the-Art Research on Multiple Myeloma Progression in Cancers (3 articles)
