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Cancers
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Ultrasonography for Pancreatobiliary Cancer
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Ultrasonography for Pancreatobiliary Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 2621

Special Issue Editor

Dr. Yasunobu Yamashita

E-Mail Website
Guest Editor
Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
Interests: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA

Special Issue Information

Dear Colleagues,

The incidence and mortality rate of pancreatobiliary cancer, which has a poor prognosis, are rising rapidly. Endoscopic ultrasonography (EUS) and abdominal ultrasonography play an important role in the diagnosis and treatment of this cancer, and abdominal ultrasonography is useful for the screening. EUS provides superior spatial resolution compared with other imaging modalities such as transabdominal ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), and it is considered among the most reliable and efficient diagnostic modalities for pancreatic lesions. Therefore, it is useful for the detection of small pancreatic lesions. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has a high accuracy rate and low complication rate; thus, it is the final tool dictating the therapeutic strategy. EUS-FNA-related technique (interventional EUS) has been extensively applied to the treatment of pancreatobiliary diseases. This Special Issue aims to provide a comprehensive overview of recent advances in terms of both the diagnosis and treatment of pancreatobiliary cancer.

Dr. Yasunobu Yamashita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endoscopic ultrasonography
  • abdominal ultrasonography
  • early diagnosis project
  • screening
  • EUS-FNA
  • interventional EUS
  • enhancement EUS
  • EUS-RFA

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Published Papers (3 papers)

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Research

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14 pages, 5355 KB  
Article
Risk Factors for Long-Term Delayed Gastric Emptying and Its Impact on the Quality of Life After Laparoscopic Pylorus-Preserving Gastrectomy in Patients with Gastric Cancer: Secondary Analysis of the Prospective Multicenter Trial KLASS-04
by Young Shick Rhee, Sang Soo Eom, Bang Wool Eom, Dong-eun Lee, Sa-Hong Kim, Hyuk-Joon Lee, Young-Woo Kim, Han-Kwang Yang, Do Joong Park, Sang Uk Han, Hyung-Ho Kim, Woo Jin Hyung, Ji-Ho Park, Yun-Suhk Suh, Oh Kyoung Kwon, Wook Kim, Young-Kyu Park, Hong Man Yoon, Sang-Hoon Ahn, Seong-Ho Kong and Keun Won Ryuadd Show full author list remove Hide full author list
Cancers 2025, 17(15), 2527; https://doi.org/10.3390/cancers17152527 - 30 Jul 2025
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Abstract
Background/Objectives: Delayed gastric emptying (DGE) is a well-known complication of laparoscopic pylorus-preserving gastrectomy (LPPG). Patients who underwent LPPG in the KLASS-04 trial, which was a multicenter prospective randomized control trial comparing LPPG and laparoscopic distal gastrectomy (LDG), showed an unneglectable incidence of long-term [...] Read more.
Background/Objectives: Delayed gastric emptying (DGE) is a well-known complication of laparoscopic pylorus-preserving gastrectomy (LPPG). Patients who underwent LPPG in the KLASS-04 trial, which was a multicenter prospective randomized control trial comparing LPPG and laparoscopic distal gastrectomy (LDG), showed an unneglectable incidence of long-term DGE compared to patients who underwent LDG. This study aimed to identify the multifactorial risk factors associated with DGE and to analyze the quality of life (QoL) of patients with DGE following LPPG. Methods: DGE was defined as “nearly normal diet residue” at least once in the endoscopic follow-up at 1, 2, and 3 years after the surgery. Clinicopathological features, surgical outcomes, and QoL were compared between the DGE and non-DGE groups. Results: DGE was observed in 21/124 patients (16.3%) who underwent LPPG. Patients without previous abdominal surgery had a higher incidence of DGE in the univariate (32% vs. 4.8%, p = 0.011) and logistic regression analyses (odds ratio: 0.106, 95% confidence interval: 0.014–0.824, p = 0.032). Patients with DGE reported more symptoms of nausea and vomiting (p = 0.004), constipation (p = 0.04), and a dry mouth (p = 0.005). Conclusions: Despite the strict protocol used to avoid well-known risk factors for DGE, such as damage to the hepatic branch of the vagus nerve, infrapyloric artery and vein, and short antral cuff, the LPPG group of the KLASS-04 trial exhibited a considerable incidence of DGE. No clinicopathological or surgical factors, other than the absence of a previous surgical history, were identified as multifactorial risk factors for DGE. However, DGE had a negative impact on the QoL of patients. Full article
(This article belongs to the Special Issue Ultrasonography for Pancreatobiliary Cancer)
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Review

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14 pages, 727 KB  
Review
Endoscopic Ablation in Cholangiocarcinoma
by Cristina Natha, Varun Vemulapalli and Nirav Thosani
Cancers 2025, 17(17), 2843; https://doi.org/10.3390/cancers17172843 - 29 Aug 2025
Abstract
Cholangiocarcinoma is a rare, highly aggressive malignancy of the hepatobiliary tract with poor prognosis, often diagnosed at advanced stages when curative surgical resection is not feasible. Management increasingly relies on advanced endoscopic interventions to address malignant biliary obstruction and improve clinical outcomes. Beyond [...] Read more.
Cholangiocarcinoma is a rare, highly aggressive malignancy of the hepatobiliary tract with poor prognosis, often diagnosed at advanced stages when curative surgical resection is not feasible. Management increasingly relies on advanced endoscopic interventions to address malignant biliary obstruction and improve clinical outcomes. Beyond conventional biliary stenting, adjunctive endoscopic ablation therapies have emerged as promising strategies to improve both stent patency and survival. This review comprehensively examines the evolving role of radiofrequency ablation and photodynamic therapy in the treatment of unresectable cholangiocarcinoma. Radiofrequency ablation utilizes localized thermal energy to induce coagulative tumor necrosis and offers advantages including procedural simplicity, favorable safety profile, and cost-effectiveness; however, its efficacy may be limited by tumor size, location, and proximity to critical structures. In contrast, photodynamic therapy employs light-activated photosensitizers to selectively induce cytotoxicity in malignant tissue, demonstrating superior outcomes in prolonging both stent patency and overall survival across multiple studies and meta-analyses. Photodynamic therapy’s ability to treat more diffuse and peripheral lesions represents an important advantage, though its use is limited by photosensitivity reactions and shallow tissue penetration. Ultimately, endoscopic ablation therapies represent valuable adjunctive options in the multidisciplinary care of patients with unresectable cholangiocarcinoma. As technological advances continue and more comparative data emerge, optimized patient selection and individualized integration of these therapies hold potential to significantly improve outcomes in this challenging malignancy. Full article
(This article belongs to the Special Issue Ultrasonography for Pancreatobiliary Cancer)
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16 pages, 2086 KB  
Review
Advances in Endoscopic Ultrasonography-Based Diagnosis of Pancreatic Lesions: Narrative Review
by Yasunobu Yamashita, Hirofumi Yamazaki, Akiya Nakahata, Tomoya Emori, Yuki Kawaji, Takashi Tamura, Masahiro Itonaga, Reiko Ashida and Masayuki Kitano
Cancers 2025, 17(2), 172; https://doi.org/10.3390/cancers17020172 - 7 Jan 2025
Viewed by 1684
Abstract
Pancreatic cancer is the fourth deadliest cancer in the U [...] Full article
(This article belongs to the Special Issue Ultrasonography for Pancreatobiliary Cancer)
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