Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 1320
Special Issue Editors
Interests: gliomas; glioblastoma stem cells; targeted therapies; tumor heterogeneity
Special Issues, Collections and Topics in MDPI journals
Interests: cancer neurosciences; gliomas; functional network interactions; specific brain mapping strategies
Special Issue Information
Dear Colleagues,
Recent advances have been made in diagnosing intra-cranial tumors, with a better definition of inter-tumoral heterogeneity. For instance, the WHO introduced a histo-molecular classification of gliomas in 2016, and new tumor entities, such as high-grade gliomas with piloid features, have been described. Additionally, there is also a high degree of intra-tumoral heterogeneity. Multiple tumor sampling and tumor resampling at progression have deciphered this heterogeneity at the spatial and temporal levels. From a functional viewpoint, the coexistence of areas characterized by different degrees of intrinsic connectivity has been demonstrated in gliomas. Moreover, single-cell analysis, notably applied to gliomas, has offered a better overview of inter- and intra-tumoral heterogeneity, identifying different transcriptomic signatures within the same tumor. This Special Issue aims to provide updated data regarding the inter- and intra-tumoral heterogeneity of intracranial neoplasms (gliomas, meningiomas, metastasis, etc.) and determine how this heterogeneity will influence therapeutic strategies and outcomes.
Prof. Dr. Francois Ducray
Dr. Shawn L. Hervey-Jumper
Dr. Thiebaud Picart
Guest Editors
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Keywords
- glioma
- histo-molecular classification
- intra-tumoral heterogeneity
- inter-tumoral heterogeneity
- meningioma
- neuro-oncology
- neurosurgery
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