Each year, the Nobel Prizes shine a spotlight on discoveries and ideas that have reshaped how we understand the world and ourselves. Rooted in Alfred Nobel’s vision of rewarding contributions “for the greatest benefit to humankind,” the prizes recognize milestones that often began as bold questions, painstaking experiments, or courageous stands. Beyond honoring individual brilliance, they tell a larger story of human progress—how curiosity, creativity, and determination can transform lives, opening new possibilities for health, understanding, and peace.

“Stress-Induced Proteasome Sub-Cellular Translocation in Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias”
by Shunit Neeman-Egozi, Ido Livneh, Irit Dolgopyat, Udi Nussinovitch, Helena Milman, Nadav Cohen, Binyamin Eisen, Aaron Ciechanover and Ofer Binah
Int. J. Mol. Sci. 2024, 25(9), 4932; https://doi.org/10.3390/ijms25094932

“Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression”
by Ikrame Lazar, Ido Livneh, Aaron Ciechanover and Bertrand Fabre
Cells 2024, 13(2), 180; https://doi.org/10.3390/cells13020180

“Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy”
by Ortal Nahum-Ankonina, Efrat Kurtzwald-Josefson, Aaron Ciechanover, Maayan Waldman, Orna Shwartz-Rohaker, Edith Hochhauser, Sam J. Meyer, Dan Aravot, Moshe Phillip and Yaron D. Barac
Int. J. Mol. Sci. 2023, 24(20), 15376; https://doi.org/10.3390/ijms242015376

“Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin”
by Anh Minh Thao Nguyen, Moran Shalev-Benami, Chloé Rosa-Teijeiro, Ana Victoria Ibarra-Meneses, Ada Yonath, Anat Bashan, Charles L. Jaffe, Martin Olivier, Christopher Fernandez-Prada and William D. Lubell
Biomedicines 2023, 11(9), 2541; https://doi.org/10.3390/biomedicines11092541

“Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A_2AAR in Lipid Nanodiscs”
by Canyong Guo, Lingyun Yang, Zhijun Liu, Dongsheng Liu and Kurt Wüthrich
Molecules 2023, 28(14), 5419; https://doi.org/10.3390/molecules28145419

“Light-Control over Casein Kinase 1δ Activity with Photopharmacology: A Clear Case for Arylazopyrazole-Based Inhibitors”
by Albert M. Schulte, Dušan Kolarski, Vidya Sundaram, Ashutosh Srivastava, Florence Tama, Ben L. Feringa and Wiktor Szymanski
Int. J. Mol. Sci. 2022, 23(10), 5326; https://doi.org/10.3390/ijms23105326

“G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling”
by Haoyi Ge, Huixia Wang, Benxun Pan, Dandan Feng, Canyong Guo, Lingyun Yang, Dongsheng Liu and Kurt Wüthrich
Molecules 2022, 27(9), 2658; https://doi.org/10.3390/molecules27092658

“Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes”
by Tony Le Gall, Mathieu Berchel, Lee Davies, Angélique Mottais, Rosy Ghanem, Alain Fautrel, Deborah Gill, Steve Hyde, Pierre Lehn, Jean-Marie Lehn et al.
Pharmaceutics 2022, 14(1), 25; https://doi.org/10.3390/pharmaceutics14010025

“Tumor Immunotherapy Using A_2A Adenosine Receptor Antagonists”
by Jinfeng Zhang, Wenzhong Yan, Wenwen Duan, Kurt Wüthrich and Jianjun Cheng
Pharmaceuticals 2020, 13(9), 237; https://doi.org/10.3390/ph13090237

“Recent Advancements in Stereoselective Olefin Metathesis Using Ruthenium Catalysts”
by T. Patrick Montgomery, Adam M. Johns and Robert H. Grubbs
Catalysts 2017, 7(3), 87; https://doi.org/10.3390/catal7030087

“Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A”
by Gilad Kaplan, Fred Lee, Masanori Onda, Emily Kolyvas, Gaurav Bhardwaj, David Baker and Ira Pastan
Toxins 2016, 8(8), 217; https://doi.org/10.3390/toxins8080217

“Advanced Electrodes for High Power Li-ion Batteries”
by Karim Zaghib, Alain Mauger, Henri Groult, John B. Goodenough and Christian M. Julien
Materials 2013, 6(3), 1028-1049; https://doi.org/10.3390/ma6031028