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Bioengineering, Volume 6, Issue 2

June 2019 - 28 articles

Cover Story: In tissue engineering, designs of scaffolds are crucial for cell attachment and proliferation. In this study, we explored electrospun PMMA scaffolds and spin-coated film in terms of initial osteoblast anchoring to produce geometries: nanofibers, microfibers, ribbons, and films. We showed high-resolution SEM images of cells shapes, attachments, and filopodia formation with respect to scaffold architectures. PMMA microfibers with the highest average fiber diameter in the range of 3.5 µm provided beneficial micro-environment for cell spreading and promoted the best integration. View this paper.
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Articles (28)

  • Article
  • Open Access
9 Citations
6,232 Views
12 Pages

Inflammation is a process driven by underlying cell-cell communication and many other factors. In this study, a model of cell-cell communications was proposed to study factors driving the inflammation time course. Analyses of inflammations that are d...

  • Article
  • Open Access
6 Citations
10,020 Views
16 Pages

Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

  • Olusegun Folarin,
  • Darren Nesbeth,
  • John M. Ward and
  • Eli Keshavarz-Moore

There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA. In order to be an effective therapeutic, high yield and high level of supercoiling are required....

  • Article
  • Open Access
6 Citations
8,225 Views
35 Pages

This paper focuses on cytotoxicity examination of superparamagnetic iron oxide nanoparticles (SPIONs) using different methods, including impedance spectroscopy. Recent advances of SPIONs for clinical and research applications have triggered the need...

  • Review
  • Open Access
83 Citations
10,722 Views
26 Pages

In the last decade, several engineered gold-based nanomaterials, such as spheres, rods, stars, cubes, hollow particles, and nanocapsules have been widely explored in biomedical fields, in particular in therapy and diagnostics. As well as different sh...

  • Article
  • Open Access
5 Citations
8,224 Views
20 Pages

A Microcavity Array-Based 4D Cell Culture Platform

  • Cordula Nies,
  • Tobias Rubner,
  • Hanna Lorig,
  • Vera Colditz,
  • Helen Seelmann,
  • Andreas Müller and
  • Eric Gottwald

(1) Background: We describe a 4D cell culture platform with which we tried to detect and to characterize migration dynamics of single hematopoietic stem cells in polymer film microcavity arrays integrated into a microtiter plate. (2) Methods: The sys...

  • Article
  • Open Access
14 Citations
9,300 Views
16 Pages

Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression

  • Joseph Chen,
  • Sourav S. Patnaik,
  • R. K. Prabhu,
  • Lauren B. Priddy,
  • Jean-Luc Bouvard,
  • Esteban Marin,
  • Mark F. Horstemeyer,
  • Jun Liao and
  • Lakiesha N. Williams

In automobile accidents, abdominal injuries are often life-threatening yet not apparent at the time of initial injury. The liver is the most commonly injured abdominal organ from this type of trauma. In contrast to current safety tests involving cras...

  • Review
  • Open Access
22 Citations
12,032 Views
24 Pages

Transplantation of human pluripotent stem cell (hPSCs)-derived cardiomyocytes for the treatment of heart failure is a promising therapy. In order to implement this therapy requiring numerous cardiomyocytes, substantial production of hPSCs followed by...

  • Review
  • Open Access
38 Citations
12,424 Views
40 Pages

Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling

  • Chung-Hao Lee,
  • Devin W. Laurence,
  • Colton J. Ross,
  • Katherine E. Kramer,
  • Anju R. Babu,
  • Emily L. Johnson,
  • Ming-Chen Hsu,
  • Ankush Aggarwal,
  • Arshid Mir and
  • Harold M. Burkhart
  • + 3 authors

Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus, may lead to functional tricuspid regurgitation (FTR), where...

  • Article
  • Open Access
9 Citations
9,683 Views
18 Pages

The purpose of this research study was to explore the possibility to develop a brain-computer interface (BCI). The main objective was that the BCI should be able to recognize brain activity. BCI is an emerging technology which focuses on communicatio...

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Bioengineering - ISSN 2306-5354