Next Article in Journal
Inhibition of Demineralization at Restoration Margins of Z100 and Tetric EvoCeram Bulk Fill in Dentin and Enamel
Next Article in Special Issue
Hydrogels for Liver Tissue Engineering
Previous Article in Journal
Polyhydroxyalkanoate Biosynthesis at the Edge of Water Activitiy-Haloarchaea as Biopolyester Factories
Previous Article in Special Issue
3D Printing for Bio-Synthetic Biliary Stents
Open AccessArticle

Oxygen Persufflation in Liver Transplantation Results of a Randomized Controlled Trial

1
General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen-Duisburg, 45147 Essen, Germany
2
Surgical Research Department, General, Visceral and Transplantation Surgery, University Hospital Essen, University Essen-Duisburg, 45147 Essen, Germany
*
Author to whom correspondence should be addressed.
Bioengineering 2019, 6(2), 35; https://doi.org/10.3390/bioengineering6020035
Received: 14 March 2019 / Revised: 24 April 2019 / Accepted: 25 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Bioengineering Liver Transplantation)
  |  
PDF [1052 KB, uploaded 27 April 2019]
  |  

Abstract

Oxygen persufflation has shown experimentally to favorably influence hepatic energy dependent pathways and to improve survival after transplantation. The present trial evaluated oxygen persufflation as adjunct in clinical liver preservation. A total of n = 116 adult patients (age: 54 (23–68) years, M/F: 70/46), were enrolled in this prospective randomized study. Grafts were randomized to either oxygen persufflation for ≥2 h (O2) or mere cold storage (control). Only liver grafts from donors ≥55 years and/or marginal grafts after multiple rejections by other centers were included. Primary endpoint was peak-aspartate aminotransferase (AST) level until post-operative day 3. Standard parameters including graft- and patient survival were analyzed by uni- and multivariate analysis. Both study groups were comparable except for a longer ICU stay (4 versus 3 days) of the donors and a higher recipient age (57 versus 52 years) in the O2-group. Serum levels of TNF alpha were significantly reduced after oxygen persufflation (p < 0.05). Median peak-AST values did not differ between the groups (O2: 580 U/l, control: 699 U/l). Five year graft- and patient survival was similar. Subgroup analysis demonstrated a positive effect of oxygen persufflation concerning the development of early allograft dysfunction (EAD), in donors with a history of cardiopulmonary resuscitation and elevated ALT values, and concerning older or macrosteatotic livers. This study favors pre-implantation O2-persufflation in concrete subcategories of less than optimal liver grafts, for which oxygen persufflation can be considered a safe, cheap and easy applicable reconditioning method. View Full-Text
Keywords: liver transplantation; oxygen persufflation; reconditioning; randomized controlled trail liver transplantation; oxygen persufflation; reconditioning; randomized controlled trail
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Gallinat, A.; Hoyer, D.P.; Sotiropoulos, G.; Treckmann, J.; Benkoe, T.; Belker, J.; Saner, F.; Paul, A.; Minor, T. Oxygen Persufflation in Liver Transplantation Results of a Randomized Controlled Trial. Bioengineering 2019, 6, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top