Special Issue "Genetic and Process Engineering Tools for Next Generation Cell Factories"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (15 January 2019)

Special Issue Editors

Guest Editor
Dr. Neil Dixon

University of Manchester, Manchester Institute of Biotechnology, Manchester, United Kingdom
Website | E-Mail
Interests: chemical biology; molecular detection/recognition; synthetic biology
Guest Editor
Dr. Gerald Striedner

Department of Biotechnology, Universitat fur Bodenkultur Wien, Vienna, Austria
Website | E-Mail
Interests: chemical biology; molecular detection/recognition; synthetic biology

Special Issue Information

Dear Colleagues,

This Special Issue is on the production and processing of therapeutic proteins and industrial enzymes from microbial hosts, with a focus on host cell engineering strategies to minimize host synthetic burden, reduce the impact on down-stream purification processes and to maximize the productivity of manufacturing processes. Integrated genetic engineering and process engineering approaches, for instance, where genetic modification of the host allows for a new processing strategy, or indeed where a problem identified in the process environment, is solved via genetic engineering.

This would include genetic engineering strategies to enhance product functionality/activity/quality, and to facilitate isolation and purification, examples could include: i) expression control tools to permit temporal, tuneable, and/or growth phase dependent induction of gene expression; ii) host engineering to introduce novel function or enhanced capability, e.g., the use of folding modulators, optimization of host secretion systems, expression of heterologous secretion system; iii) host engineering to remove or reduce unwanted characteristics, e.g., knock-out of proteases, membrane engineering for product release, depletion of common host contaminants, e.g., co-purifying proteins/DNA/RNA/lipopolysaccharides; and iv) product engineering approaches for enhanced expression, functionality or purification, e.g., purification tags, cross-linking modalities for conjugation and immobilization.

The field of process engineering could include: i) HTP small-scale techniques for process optimization, characterization, clone and process condition screening; ii) advanced automation concepts for process operation, data processing, storage and retrieval; iii) methodologies for process monitoring, modelling and model predictive process control; iv) bioprocess integration and intensification along scales and unit operations and across disciplines; v) issues related to batch or continuous process operation mode; and vi) media design concepts.

Dr. Neil Dixon
Dr. Gerald Striedner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

There is no accepted submissions to this special issue at this moment.
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