Special Issue "Genetic and Process Engineering Tools for Next Generation Cell Factories"
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (15 January 2019)
This Special Issue is on the production and processing of therapeutic proteins and industrial enzymes from microbial hosts, with a focus on host cell engineering strategies to minimize host synthetic burden, reduce the impact on down-stream purification processes and to maximize the productivity of manufacturing processes. Integrated genetic engineering and process engineering approaches, for instance, where genetic modification of the host allows for a new processing strategy, or indeed where a problem identified in the process environment, is solved via genetic engineering.
This would include genetic engineering strategies to enhance product functionality/activity/quality, and to facilitate isolation and purification, examples could include: i) expression control tools to permit temporal, tuneable, and/or growth phase dependent induction of gene expression; ii) host engineering to introduce novel function or enhanced capability, e.g., the use of folding modulators, optimization of host secretion systems, expression of heterologous secretion system; iii) host engineering to remove or reduce unwanted characteristics, e.g., knock-out of proteases, membrane engineering for product release, depletion of common host contaminants, e.g., co-purifying proteins/DNA/RNA/lipopolysaccharides; and iv) product engineering approaches for enhanced expression, functionality or purification, e.g., purification tags, cross-linking modalities for conjugation and immobilization.
The field of process engineering could include: i) HTP small-scale techniques for process optimization, characterization, clone and process condition screening; ii) advanced automation concepts for process operation, data processing, storage and retrieval; iii) methodologies for process monitoring, modelling and model predictive process control; iv) bioprocess integration and intensification along scales and unit operations and across disciplines; v) issues related to batch or continuous process operation mode; and vi) media design concepts.
Dr. Neil Dixon
Dr. Gerald Striedner
Manuscript Submission Information
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