Advanced Dynamic Cell and Tissue Culture, Volume 2

Dear Colleagues,

“Classical” standard cell cultivation is still performed under static conditions on 2 D plastic surfaces in ambient atmosphere. These conditions do not mimic physiological in vivo conditions for human primary cells including stem and progenitor cells. For improving cell culture conditions and thus functionality of cells and tissues the expansion and differentiation should be performed in scalable bioreactors in/or on 3 D scaffolds under dynamic conditions. These bioreactor based bioprocesses can be automated and controlled resulting in optimized transport of nutrients and metabolic waste as well as in monitoring and control of the tissue microenvironment.

The current Special Issue wants to highlight new strategies for the development of bioprocesses for organ specific cell cultivation as well as stem cell expansion and differentiation. New designs for 3 D cell culture approaches including co-cultures and scalable systems shall be presented and applications are welcome from the whole field of cell based therapies and in vitro tests. This issue is open for papers addressing:

• 3 D biomaterials for cell and tissue culture
• Bioreactor design and optimization including automation
• Microfluidics (e.g. organ on a chip)
• Stem cell expansion and differentiation including tissue engineering approaches
• Application of physiological conditions including mechanical stimulation
• Sensors and monitoring devices in 3 D cell cultures

We look forward to receiving your contributions for this Special Issue.

Prof. Dr. Cornelia Kasper
Dr. -Ing. Jan Hansmann
Dr. Dominik Egger
Guest Editors

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