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Bioengineering an Artificial Human Blood–Brain Barrier in Rodents

Department of Neurological Surgery, UC Davis Medical Center, Sacramento, CA 95811, USA
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Bioengineering 2019, 6(2), 38; https://doi.org/10.3390/bioengineering6020038
Received: 29 March 2019 / Revised: 18 April 2019 / Accepted: 23 April 2019 / Published: 30 April 2019
(This article belongs to the Special Issue Organs-on-Chips)
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Abstract

Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling. View Full-Text
Keywords: blood–brain barrier; organoid; vascularization; perfusion; cerebrovascular disease; immune system; NSG mouse blood–brain barrier; organoid; vascularization; perfusion; cerebrovascular disease; immune system; NSG mouse
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Kamal, K.; Waldau, B. Bioengineering an Artificial Human Blood–Brain Barrier in Rodents. Bioengineering 2019, 6, 38.

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