Special Issue "Advances in Biological Tissue Biomechanics"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: 15 March 2019

Special Issue Editors

Guest Editor
Dr. Chung-Hao Lee

Assistant Professor, School of Aerospace and Mechanical Engineering; Affiliated Faculty Member, Institute for Biomedical Engineering, Science and Technology; The University of Oklahoma, OK, USA
Website | E-Mail
Interests: cardiovascular heart valve biomechanics; multi-scale modeling; biomaterials design
Guest Editor
Dr. Jun Liao

Associate Professor, Department of Bioengineering, University of Texas at Arlington, TX, USA
Website | E-Mail
Interests: tissue biomechanics; tissue regeneration

Special Issue Information

Dear Colleagues,

Advanced experimental and computational biomechanics have become essential components for a better understanding of the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms towards the facilitations of patient-specific diagnostics and individualized surgery planning.

This Special Issue on “Advances in Biological Tissue Biomechanics”, therefore, will focus on original research papers and comprehensive reviews, dealing with cutting-edge experimental and computational methodologies for multiscale biomechanical investigations of biological tissues in the human body system. Topics of interest for this Special Issue include, but are not limited to, the following:

  1. Advanced experimental techniques for characterizing biological tissue mechanics
  2. Novel microstructure-based constitutive model for biological tissues
  3. Growth, remodeling and repair in biological tissues
  4. Quantification of in vivo functional biomechanical properties of biological tissues
  5. Investigations of interrelationship of tissue’s biomechanical behavior to its underlying microstructure
  6. Verification, validation and uncertainty quantification in image-based patient-specific simulations
  7. Advanced computational biomechanics, such as reduced-order modeling, for fast personalized surgery simulations and pre-operative treatment planning
  8. Molecular and cellular biomechanics informed tissue biomechanics

All research areas considered relevant as long as experimentations and/or predictive simulations are the main study drivers.

Dr. Chung-Hao Lee
Dr. Jun Liao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • in vivo stresses/strains
  • constitutive models
  • growth and remodeling (G&R)
  • multiscale biomechanics
  • patient-specific modeling

Published Papers (1 paper)

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Open AccessArticle Adverse Hemodynamic Conditions Associated with Mechanical Heart Valve Leaflet Immobility
Bioengineering 2018, 5(3), 74; https://doi.org/10.3390/bioengineering5030074
Received: 24 July 2018 / Revised: 8 September 2018 / Accepted: 10 September 2018 / Published: 16 September 2018
Cited by 1 | PDF Full-text (5862 KB) | HTML Full-text | XML Full-text
Artificial heart valves may dysfunction, leading to thrombus and/or pannus formations. Computational fluid dynamics is a promising tool for improved understanding of heart valve hemodynamics that quantify detailed flow velocities and turbulent stresses to complement Doppler measurements. This combined information can assist in [...] Read more.
Artificial heart valves may dysfunction, leading to thrombus and/or pannus formations. Computational fluid dynamics is a promising tool for improved understanding of heart valve hemodynamics that quantify detailed flow velocities and turbulent stresses to complement Doppler measurements. This combined information can assist in choosing optimal prosthesis for individual patients, aiding in the development of improved valve designs, and illuminating subtle changes to help guide more timely early intervention of valve dysfunction. In this computational study, flow characteristics around a bileaflet mechanical heart valve were investigated. The study focused on the hemodynamic effects of leaflet immobility, specifically, where one leaflet does not fully open. Results showed that leaflet immobility increased the principal turbulent stresses (up to 400%), and increased forces and moments on both leaflets (up to 600% and 4000%, respectively). These unfavorable conditions elevate the risk of blood cell damage and platelet activation, which are known to cascade to more severe leaflet dysfunction. Leaflet immobility appeared to cause maximal velocity within the lateral orifices. This points to the possible importance of measuring maximal velocity at the lateral orifices by Doppler ultrasound (in addition to the central orifice, which is current practice) to determine accurate pressure gradients as markers of valve dysfunction. Full article
(This article belongs to the Special Issue Advances in Biological Tissue Biomechanics)

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