Next Article in Journal / Special Issue
Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects
Previous Article in Journal
Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
Previous Article in Special Issue
Adverse Hemodynamic Conditions Associated with Mechanical Heart Valve Leaflet Immobility
Article Menu

Export Article

Open AccessArticle

Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure

Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA
Author to whom correspondence should be addressed.
Bioengineering 2019, 6(2), 39;
Received: 9 March 2019 / Revised: 3 May 2019 / Accepted: 5 May 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Advances in Biological Tissue Biomechanics)
PDF [5801 KB, uploaded 7 May 2019]
  |     |  


The progression of calcific aortic valve disease (CAVD) is characterized by extracellular matrix (ECM) remodeling, leading to structural abnormalities and improper valve function. The focus of the present study was to relate aortic valve leaflet axial curvature changes as a function of elastin degradation, which has been associated with CAVD. Circumferential rectangular strips (L × W = 10 × 2.5 mm) of normal and elastin-degraded (via enzymatic digestion) porcine AV leaflets were subjected to cyclic flexure (1 Hz). A significant increase in mean curvature (p < 0.05) was found in elastin-degraded leaflet specimens in comparison to un-degraded controls at both the semi-constrained (50% of maximum flexed state during specimen bending and straightening events) and fully-constrained (maximally-flexed) states. This significance did not occur in all three flexed configurations when measurements were performed using either minimum or maximum curvature. Moreover, the mean curvature increase in the elastin-degraded leaflets was most pronounced at the instance of maximum flexure, compared to un-degraded controls. We conclude that the mean axial curvature metric can detect distinct spatial changes in aortic valve ECM arising from the loss in bulk content and/or structure of elastin, particularly when there is a high degree of tissue bending. Therefore, the instance of maximum leaflet flexure during the cardiac cycle could be targeted for mean curvature measurements and serve as a potential biomarker for elastin degradation in early CAVD remodeling. View Full-Text
Keywords: aortic valve; calcification; elastin degradation; leaflet; curvature; biomarker; early detection aortic valve; calcification; elastin degradation; leaflet; curvature; biomarker; early detection

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tesfamariam, M.D.; Mirza, A.M.; Chaparro, D.; Ali, A.Z.; Montalvan, R.; Saytashev, I.; Gonzalez, B.A.; Barreto, A.; Ramella-Roman, J.; Hutcheson, J.D.; Ramaswamy, S. Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure. Bioengineering 2019, 6, 39.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top