Special Issue "Bioengineering Liver Transplantation"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editors

Guest Editor
Dr. Luc J.W. Van der Laan

Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
Website | E-Mail
Interests: regenerative medicine; liver transplantation; stem cells; tissue engineering; liver organoids
Guest Editor
Dr. Bart Spee

Faculty of Veterinary Medicine, Utrecht University, The Netherlands
Website | E-Mail
Phone: 0031302532848
Interests: regenerative medicine; veterinary medicine; liver disease; biofabrication; stem cells
Guest Editor
Dr. Monique M. A. Verstegen

Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
Website | E-Mail
Interests: tissue engineering; bioscaffolds; liver organoids; stem cells; decellularisation

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.

The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.

In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.

We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.

Dr. Luc J.W. van der Laan
Dr. Bart Spee
Dr. Monique M. A. Verstegen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue Engineering
  • Liver regeneration
  • Graft repair
  • Liver stem cells & organoids
  • Bio scaffolds
  • Bio printing

Published Papers (1 paper)

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Research

Open AccessArticle 3D Printing for Bio-Synthetic Biliary Stents
Bioengineering 2019, 6(1), 16; https://doi.org/10.3390/bioengineering6010016
Received: 8 January 2019 / Revised: 5 February 2019 / Accepted: 6 February 2019 / Published: 9 February 2019
Cited by 1 | PDF Full-text (6078 KB) | HTML Full-text | XML Full-text
Abstract
Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. [...] Read more.
Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions. XL-PVA stents showed hydrophilic swelling and addition of radiocontrast to the stent matrix improved radiographic opacity. Collagen loaded with PMSCs contracted tightly around hydrophilic stents and dense choloangiocyte coatings were verified through histology and fluorescence microscopy. It is anticipated that design elements used in these stents may enable appropriate stent placement, provide protection of the stent-stem cell matrix against bile constituents, and potentially limit biofilm development. Overall, this approach may allow physicians to create personalized bio-integrating stents for use in biliary procedures and lays a foundation for new patient-specific stent fabrication techniques. Full article
(This article belongs to the Special Issue Bioengineering Liver Transplantation)
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