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Separations, Volume 12, Issue 6

June 2025 - 33 articles

Cover Story: The development of chromatographic processes to purify biopharmaceuticals requires tremendous experimental effort. The state-of-the-art approach, Design of Experiments, enables a systematic procedure limited to a design space described by a statistical, interpolating model; however, the experimental burden remains high. Process development would benefit from extrapolating models to reduce this burden and enable deeper process understanding and knowledge transfer. Nevertheless, such models currently lack predictive power. In an academic–industrial collaboration, we present a new biophysics-based adsorption model for developing ion-exchange chromatography processes for pharmaceuticals at a preparative scale. This model achieves high predictive power across low and high antibody load densities and even captures charge variant behavior. View this paper

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Article

656 Views

21 Pages

Influence of Micron Roughness on Droplet Adhesion and Detachment Behavior with Coal Surfaces

Siheng Hou,
Peng Xiong,
Xianshu Dong,
Hengfei Chen,
Shuhuan Li and
Yujin Sun

Separations2025, 12(6), 137;https://doi.org/10.3390/separations12060137

22 May 2025

Surface roughness directly affects the interaction between mineral surfaces and water, as well as the adhesion of particles to bubbles during mineral flotation processes. Currently, there is a significant amount of research on the relationship betwee...

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Article

678 Views

14 Pages

Mixed-Mode Chromatography: Studies on Hybrid Retention Mechanisms of Some Antihypertensive Drugs

Irinel Adriana Badea,
Andrei Mihăilă,
Dana Elena Popa,
Anca Monica Tencaliec and
Mihaela Buleandră

Separations2025, 12(6), 136;https://doi.org/10.3390/separations12060136

22 May 2025

The antihypertensive drugs indapamide, atenolol, metoprolol, propranolol and bisoprolol were considered in this research. Because they have structures that are affected by pH, developing a chromatographic method was challenging. Based on the speciati...

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1,903 Views

17 Pages

Purification of Mogroside V from Crude Extract of Siraitia grosvenorii Using Boronic Acid-Functionalized Silica Gel and Its Hypoglycemic Activity Determination

Yanmei Xu,
Laiming Li,
Pingyi Zheng,
Ran Zhao,
Mengqi Cheng,
Yanfang Su,
Jame J. Bao and
Youxin Li

Separations2025, 12(6), 135;https://doi.org/10.3390/separations12060135

22 May 2025

Mogroside V crude extract from Siraitia grosvenorii has many pharmacological effects, such as anti-diabetes, antioxidant, etc. It is being used as a kind of natural sweetener in more and more countries. The improvement of Mogroside V purity can great...

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