Table of Contents
Processes, Volume 7, Issue 4 (April 2019)
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Cover Story (view full-size image) The anti-apoptotic Mcl1 (Myeloid cell leukemia 1) protein (belonging to the Bcl2 family) is known [...] Read more. The anti-apoptotic Mcl1 (Myeloid cell leukemia 1) protein (belonging to the Bcl2 family) is known for its overexpression and promotion of apoptosis inside cells. Because the properties of the Mcl1 binding pocket are shared among its family members, designing an inhibitor that can specifically target Mcl1 and down-regulate its activity is a highly challenging process. Lanning et al (2006) developed Mcl1-specific inhibitors that exhibited a range of binding affinities towards solid tumors and cancers. In the current investigation, we used a combination of advanced computational approaches to explore the molecular basis of its binding with Mcl1. View this paper.