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Processes, Volume 7, Issue 4

2019 April - 64 articles

Cover Story: The anti-apoptotic Mcl1 (Myeloid cell leukemia 1) protein (belonging to the Bcl2 family) is known for its overexpression and promotion of apoptosis inside cells. Because the properties of the Mcl1 binding pocket are shared among its family members, designing an inhibitor that can specifically target Mcl1 and down-regulate its activity is a highly challenging process. Lanning et al (2006) developed Mcl1-specific inhibitors that exhibited a range of binding affinities towards solid tumors and cancers. In the current investigation, we used a combination of advanced computational approaches to explore the molecular basis of its binding with Mcl1. View this paper.
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Articles (64)

  • Article
  • Open Access
23 Citations
4,810 Views
15 Pages

Screening and Optimization of Demulsifiers and Flocculants Based on ASP Flooding-Produced Water

  • Bin Huang,
  • Jie Wang,
  • Wei Zhang,
  • Cheng Fu,
  • Ying Wang and
  • Xiangbin Liu

25 April 2019

The water produced by alkaline–surfactant–polymer (ASP) flooding is difficult to treat due to the presence of residual chemicals. Therefore, research and development of efficient and low-cost methods for the treatment of ASP flooding prod...

  • Article
  • Open Access
7 Citations
5,796 Views
18 Pages

Exploring Plant Sesquiterpene Diversity by Generating Chemical Networks

  • Waldeyr M. C. da Silva,
  • Jakob L. Andersen,
  • Maristela T. Holanda,
  • Maria Emília M. T. Walter,
  • Marcelo M. Brigido,
  • Peter F. Stadler and
  • Christoph Flamm

25 April 2019

Plants produce a diverse portfolio of sesquiterpenes that are important in their response to herbivores and the interaction with other plants. Their biosynthesis from farnesyl diphosphate depends on the sesquiterpene synthases that admit different cy...

  • Article
  • Open Access
6 Citations
3,666 Views
15 Pages

25 April 2019

Gas diffusivities of coal are not measured directly but are normally regressed by fitting mathematical diffusion models to fractional sorption data measured in sorption experiments. This paper firstly measured three fractional adsorption curves at va...

  • Article
  • Open Access
11 Citations
5,334 Views
18 Pages

24 April 2019

For sustainable and incremental growth, mankind is adopting renewable sources of energy along with storage systems. Storing surplus renewable energy in the form of hydrogen is a viable solution to meet continuous energy demands. In this paper the con...

  • Article
  • Open Access
8 Citations
5,541 Views
10 Pages

Characterization of the Primary Sludge from Pharmaceutical Industry Effluents and Final Disposition

  • Renata Xavier Alberico Freitas,
  • Lara Aguiar Borges,
  • Handray Fernandes de Souza,
  • Fernando Colen,
  • Alex Sander Rodrigues Cangussu,
  • Eliane Macedo Sobrinho,
  • Francine Souza Alves Fonseca,
  • Sérgio Henrique Sousa Santos,
  • Bruna Mara Aparecida de Carvalho and
  • Igor Viana Brandi

24 April 2019

The generation of large volumes of waste by industrial processes has become an object of study because of the necessity to characterize the composition of residues in order to suggest appropriate treatments and to minimize adverse environmental impac...

  • Article
  • Open Access
13 Citations
5,086 Views
12 Pages

24 April 2019

The leaflet vibration phenomenon in bileaflet mechanical heart valves (BMHVs) can cause complications such as hemolysis, leaflet damage, and valve fracture. One of the main reasons for leaflet vibration is the unsteady blood flow pressure pulsation i...

  • Article
  • Open Access
9 Citations
4,745 Views
11 Pages

The Potential for a Pellet Plant to Become a Biorefinery

  • Stefan Frodeson,
  • Jonas Berghel,
  • Magnus Ståhl,
  • Karin Granström,
  • Carl Romlin and
  • Alexander Thelander

24 April 2019

The use of bioenergy has increased globally in recent years, as has the utilization of biomaterials for various new product solutions through various biorefinery concepts. In this study, we introduce the concept of using a mechanical dewatering press...

  • Feature Paper
  • Article
  • Open Access
55 Citations
16,368 Views
35 Pages

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

  • Nirupaplava Metta,
  • Michael Ghijs,
  • Elisabeth Schäfer,
  • Ashish Kumar,
  • Philippe Cappuyns,
  • Ivo Van Assche,
  • Ravendra Singh,
  • Rohit Ramachandran,
  • Thomas De Beer and
  • Ingmar Nopens
  • + 1 author

24 April 2019

In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay betw...

  • Article
  • Open Access
5 Citations
6,146 Views
11 Pages

A Machine Learning-based Pipeline for the Classification of CTX-M in Metagenomics Samples

  • Diego Ceballos,
  • Diana López-Álvarez,
  • Gustavo Isaza,
  • Reinel Tabares-Soto,
  • Simón Orozco-Arias and
  • Carlos D. Ferrin

24 April 2019

Bacterial infections are a major global concern, since they can lead to public health problems. To address this issue, bioinformatics contributes extensively with the analysis and interpretation of in silico data by enabling to genetically characteri...

  • Article
  • Open Access
9 Citations
5,770 Views
14 Pages

VB1 Promoted Green Synthesis of Chalcones and Its Neuroprotection Potency Evaluation

  • Huanhuan Yin,
  • Ximeng Shi,
  • Hao Wang,
  • Guixia Liu and
  • Lei Ma

24 April 2019

For the first time, thiamine hydrochloride (VB1) has been employed as a catalyst for the synthesis of chalcones by metal-free Claisen–Schmidt condensation. Such an environmentally benign approach has several advantages such as a wide range of f...

  • Feature Paper
  • Article
  • Open Access
11 Citations
5,906 Views
24 Pages

24 April 2019

A kinetic model describing aqueous acrylamide homopolymerization and copolymerization of acrylamide with methylene bisacrylamide, leading to hydrogel formation, is presented and applied in the simulation of these reaction processes. This modeling app...

  • Article
  • Open Access
16 Citations
5,981 Views
14 Pages

Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellular Models

  • Sha Sha,
  • Zhuangrong Huang,
  • Cyrus D. Agarabi,
  • Scott C. Lute,
  • Kurt A. Brorson and
  • Seongkyu Yoon

23 April 2019

Monoclonal antibodies (mAbs) are commonly glycosylated and show varying levels of galactose attachment. A set of experiments in our work showed that the galactosylation level of mAbs was altered by the culture conditions of hybridoma cells. The uridi...

  • Article
  • Open Access
13 Citations
5,531 Views
9 Pages

23 April 2019

The uses of Al3+ and Fe3+ salts in chemical phosphorus removal (CPR) in activated sludge plants have increased considerably in recent years and their full impacts on downstream processes such as dewaterability and digestibility are not fully understo...

  • Feature Paper
  • Article
  • Open Access
23 Citations
5,041 Views
12 Pages

Pelletization of Torrefied Wood Using a Proteinaceous Binder Developed from Hydrolyzed Specified Risk Materials

  • Birendra B. Adhikari,
  • Michael Chae,
  • Chengyong Zhu,
  • Ataullah Khan,
  • Don Harfield,
  • Phillip Choi and
  • David C. Bressler

23 April 2019

Pressing issues such as a growing energy demand and the need for energy diversification, emission reduction, and environmental protection serve as motivation for the utilization of biomass for production of sustainable fuels. However, use of biomass...

  • Feature Paper
  • Review
  • Open Access
11 Citations
8,749 Views
25 Pages

Modular Engineering of Biomass Degradation Pathways

  • Julie E. Chaves,
  • Gerald N. Presley and
  • Joshua K. Michener

23 April 2019

Production of fuels and chemicals from renewable lignocellulosic feedstocks is a promising alternative to petroleum-derived compounds. Due to the complexity of lignocellulosic feedstocks, microbial conversion of all potential substrates will require...

  • Article
  • Open Access
9 Citations
4,800 Views
15 Pages

22 April 2019

Anionic polyamide-6 (APA-6) composites are prepared by the VARIM process using different modified ramie fabrics to study the structure and properties of different composites. This study can not only evaluate the optimal modification method for the ra...

  • Feature Paper
  • Review
  • Open Access
34 Citations
7,752 Views
24 Pages

Recent Developments in the Photocatalytic Treatment of Cyanide Wastewater: An Approach to Remediation and Recovery of Metals

  • Luis Andrés Betancourt-Buitrago,
  • Aracely Hernandez-Ramirez,
  • Jose Angel Colina-Marquez,
  • Ciro Fernando Bustillo-Lecompte,
  • Lars Rehmann and
  • Fiderman Machuca-Martinez

20 April 2019

For gold extraction, the most used extraction technique is the Merrill-Crow process, which uses lixiviants as sodium or potassium cyanide for gold leaching at alkaline conditions. The cyanide ion has an affinity not only for gold and silver, but for...

  • Article
  • Open Access
20 Citations
4,703 Views
14 Pages

19 April 2019

Shuttle-based storage and retrieval systems (SBS/RSs), a new type of “part-to-picker” system, have attracted public attention because of their flexibility and robustness. The systems consist of two sub-systems—shuttles and lifts&mda...

  • Feature Paper
  • Article
  • Open Access
3 Citations
4,988 Views
21 Pages

Investigating the Molecular Basis of N-Substituted 1-Hydroxy-4-Sulfamoyl-2-Naphthoate Compounds Binding to Mcl1

  • Kalaimathy Singaravelu,
  • Pavithra K. Balasubramanian and
  • Parthiban Marimuthu

19 April 2019

Myeloid cell leukemia-1 (Mcl1) is an anti–apoptotic protein that has gained considerable attention due to its overexpression activity prevents cell death. Therefore, a potential inhibitor that specifically targets Mcl1 with higher binding affin...

  • Article
  • Open Access
12 Citations
5,058 Views
20 Pages

18 April 2019

Convex relaxations of functions are used to provide bounding information to deterministic global optimization methods for nonconvex systems. To be useful, these relaxations must converge rapidly to the original system as the considered domain shrinks...

  • Article
  • Open Access
26 Citations
4,867 Views
14 Pages

18 April 2019

This research developed and tested a filter algorithm that serves to reduce the feature space in healthcare datasets. The algorithm binarizes the dataset, and then separately evaluates the risk ratio of each predictor with the response, and outputs r...

  • Feature Paper
  • Article
  • Open Access
16 Citations
4,713 Views
18 Pages

17 April 2019

Design and control of hyperbranched (HB) polymer architecture by way of reactor operation is key to a successful production of higher-valued HB polymers, and it is essential in order to clarify the fundamental structural characteristics formed in rep...

  • Article
  • Open Access
70 Citations
6,816 Views
14 Pages

16 April 2019

The adsorption potential of acid activated carbon prepared from leaves of Juniperus procera to remove Pb(II) and Cr(VI) toxic ions from aqueous solutions was investigated. The effects of solution pH, adsorbent mass, contact time, initial ion concentr...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,723 Views
26 Pages

Modeling On-Site Combined Heat and Power Systems Coupled to Main Process Operation

  • Cristian Pablos,
  • Alejandro Merino and
  • Luis Felipe Acebes

16 April 2019

Many production processes work with on-site Combined Heat and Power (CHP) systems to reduce their operational cost and improve their incomes by selling electricity to the external grid. Optimal management of these plants is key in order to take full...

  • Article
  • Open Access
20 Citations
4,735 Views
17 Pages

16 April 2019

Gas pressure changes during the process of coal mine gas drainage and CBM recovery. It is of great importance to understand the influence of sorption pressure on gas diffusion; however, the topic remains controversial in past studies. In this study,...

  • Article
  • Open Access
99 Citations
27,610 Views
11 Pages

Antifungal and Antibacterial Activities of Musa paradisiaca L. Peel Extract: HPLC Analysis of Phenolic and Flavonoid Contents

  • Said I. Behiry,
  • Mohmmad K. Okla,
  • Saud A. Alamri,
  • Mervat EL-Hefny,
  • Mohamed Z. M. Salem,
  • Ibrahim A. Alaraidh,
  • Hayssam M. Ali,
  • Salem M. Al-Ghtani,
  • José C. Monroy and
  • Abdelfattah Z. M. Salem

15 April 2019

In the present study, Melia azedarach wood samples that were treated with the methanolic extract of Musa paradisiaca L. peels were evaluated for their antibacterial and antifungal activities against Agrobacterium tumefaciens, Dickeya solani, Erwinia ...

  • Review
  • Open Access
66 Citations
9,667 Views
14 Pages

Alternative Environmentally Friendly Insulating Gases for SF6

  • Yong Wang,
  • Danqing Huang,
  • Jing Liu,
  • Yaru Zhang and
  • Lian Zeng

15 April 2019

Sulfur hexafluoride (SF6) shows excellent insulation performance as an insulating gas. It is suitable for various climate conditions due to its low boiling point (−64 °C). Therefore, it has been widely used in power grid equipment. However,...

  • Article
  • Open Access
23 Citations
3,609 Views
17 Pages

12 April 2019

In this paper, we developed a control chart methodology for the monitoring the mean time between two events using the belief estimator under the neutrosophic gamma distribution. The proposed control chart coefficients and the neutrosophic average run...

  • Article
  • Open Access
29 Citations
5,766 Views
24 Pages

Drying of Phyla nodiflora Leaves: Antioxidant Activity, Volatile and Phytosterol Content, Energy Consumption, and Quality Studies

  • Lisa Yen Wen Chua,
  • Bee Lin Chua,
  • Adam Figiel,
  • Chien Hwa Chong,
  • Aneta Wojdyło,
  • Antoni Szumny and
  • Jacek Łyczko

12 April 2019

Drying is an important process in the preservation of antioxidants in medicinal plants. In this study, leaves of Phyla nodiflora, or commonly known as frog fruit, were dried using convective drying (CD) at 40, 50, and 60 °C; vacuum-microwave drying (...

  • Article
  • Open Access
63 Citations
9,321 Views
25 Pages

12 April 2019

In the era of industrial revolution 4.0 (IR 4.0), sustainability has been a serious challenge of contemporary small and medium enterprises (SMEs). Using Natural Resource-Based-View (NRBV), the current paper examines the moderated mediation model of t...

  • Article
  • Open Access
46 Citations
9,596 Views
25 Pages

Modeling of Future Electricity Generation and Emissions Assessment for Pakistan

  • Abdullah Mengal,
  • Nayyar Hussain Mirjat,
  • Gordhan Das Walasai,
  • Shoaib Ahmed Khatri,
  • Khanji Harijan and
  • Mohammad Aslam Uqaili

12 April 2019

Electricity demand in Pakistan has consistently increased in the past two decades. However, this demand is so far partially met due to insufficient supply, inefficient power plants, high transmission and distribution system losses, lack of effective...

  • Review
  • Open Access
34 Citations
24,503 Views
17 Pages

Metabolic Engineering and Fermentation Process Strategies for L-Tryptophan Production by Escherichia coli

  • Lina Liu,
  • Muhammad Bilal,
  • Hongzhen Luo,
  • Yuping Zhao and
  • Hafiz M. N. Iqbal

12 April 2019

L-tryptophan is an essential aromatic amino acid that has been widely used in medicine, food, and animal feed. Microbial biosynthesis of L-tryptophan through metabolic engineering approaches represents a sustainable, cost-effective, and environmental...

  • Article
  • Open Access
12 Citations
4,475 Views
12 Pages

Preparation and Characterization of Furosemide-Silver Complex Loaded Chitosan Nanoparticles

  • Victor A. Rodriguez,
  • Pradeep Kumar Bolla,
  • Rahul S. Kalhapure,
  • Sai Hanuman Sagar Boddu,
  • Rabin Neupane,
  • Julian Franco and
  • Jwala Renukuntla

11 April 2019

Antibiotic-resistant bacteria may result in serious infections which are difficult to treat. In addition, the poor antibiotic pipeline has contributed to the crisis. Recently, a complex of furosemide and silver (Ag-FSE) has been reported as a potenti...

  • Article
  • Open Access
81 Citations
10,669 Views
12 Pages

Recycling of Carbon Fibers from CFRP Waste by Microwave Thermolysis

  • Jianying Deng,
  • Lei Xu,
  • Libo Zhang,
  • Jinhui Peng,
  • Shenghui Guo,
  • Jianhua Liu and
  • Sivasankar Koppala

11 April 2019

With the growth of the use of carbon fiber-reinforced polymer (CFRP) in various fields, the recovery of carbon fibers from CFRP waste is becoming a significant research direction. In the present work, degrading epoxy resin and recycling carbon fibers...

  • Article
  • Open Access
22 Citations
6,017 Views
12 Pages

Benzoic Acid Derivatives of Ifloga spicata (Forssk.) Sch.Bip. as Potential Anti-Leishmanial against Leishmania tropica

  • Syed Majid Shah,
  • Farhat Ullah,
  • Muhammad Ayaz,
  • Abdul Sadiq,
  • Sajid Hussain,
  • Azhar-ul-Haq Ali Shah,
  • Syed Adnan Ali Shah,
  • Nazif Ullah,
  • Farman Ullah and
  • Akhtar Nadhman
  • + 1 author

11 April 2019

This study aimed to appraise the anti-leishmanial potentials of benzoic acid derivatives, including methyl 3,4-dihydroxybenzoate (compound 1) and octadecyl benzoate (compound 2), isolated from the ethnomedicinally important plant Ifloga spicata (I. s...

  • Article
  • Open Access
70 Citations
10,198 Views
25 Pages

Isosteric Heat: Comparative Study between Clausius–Clapeyron, CSK and Adsorption Calorimetry Methods

  • Liliana Giraldo,
  • Paola Rodriguez-Estupiñán and
  • Juan Carlos Moreno-Piraján

10 April 2019

This work presents the calorimetric study of five adsorbents with different chemical and textural characteristics: MOF-199, MCM-41, SBA-15, activated carbon prepared from corn cob (GACKP) and graphite. These solids were used to establish the differen...

  • Article
  • Open Access
13 Citations
5,197 Views
19 Pages

10 April 2019

The lateral inlet/outlet plays a critical role in the connecting tunnels of a water delivery system in a pumped hydroelectric storage (PHES). Therefore, the shape of the inlet/outlet was improved through computational fluid dynamics (CFD) optimizatio...

  • Article
  • Open Access
8 Citations
3,651 Views
24 Pages

9 April 2019

The enhanced geothermal system (EGS) reservoir consists of a heterogeneous fracture network and rock matrix, and the heterogeneity of the reservoir has a significant influence on the system’s electricity generation performance. In this study, w...

  • Feature Paper
  • Article
  • Open Access
25 Citations
4,617 Views
14 Pages

Enhancing Oxygen Permeation via the Incorporation of Silver Inside Perovskite Oxide Membranes

  • Teng Ma,
  • Ning Han,
  • Bo Meng,
  • Naitao Yang,
  • Zhonghua Zhu and
  • Shaomin Liu

8 April 2019

As a possible novel cost-effective method for oxygen production from air separation, ion-conducting ceramic membranes are becoming a hot research topic due to their potentials in clean energy and environmental processes. Oxygen separation via these i...

  • Feature Paper
  • Article
  • Open Access
16 Citations
8,196 Views
18 Pages

A Hybrid Multi-Objective Optimization Framework for Preliminary Process Design Based on Health, Safety and Environmental Impact

  • Shin Yee Teh,
  • Kian Boon Chua,
  • Boon Hooi Hong,
  • Alex J. W. Ling,
  • Viknesh Andiappan,
  • Dominic C. Y. Foo,
  • Mimi H. Hassim and
  • Denny K. S. Ng

8 April 2019

Due to increasingly stringent legal requirements and escalating environmental control costs, chemical industries have paid close attention to sustainable development without compromising their economic performance. Thus, chemical industries are in ne...

  • Article
  • Open Access
5 Citations
4,148 Views
10 Pages

Size Separation of Silica Particles Using a Magnetite-Containing Gel-Packed Column

  • Manoka Miyoshi,
  • Kosuke Takayanagi,
  • Shintaro Morisada,
  • Keisuke Ohto,
  • Hidetaka Kawakita and
  • Shoichiro Morita

8 April 2019

A magnetite-containing gel was prepared by water-in-oil radical polymerization of N,N-dimethylacrylamide and N,N′-methylenebisacrylamide in the presence of magnetite. The size of the prepared gel particles was 86 µm. The obtained magnetit...

  • Article
  • Open Access
18 Citations
5,760 Views
16 Pages

High-Performance Chlorine-Doped Cu2O Catalysts for the Ethynylation of Formaldehyde

  • Jie Gao,
  • Guofeng Yang,
  • Haitao Li,
  • Mei Dong,
  • Zhipeng Wang and
  • Zhikai Li

6 April 2019

The in situ formed Cu+ species serve as active sites in the ethynylation of formaldehyde. The key problem that needs to be solved in this process is how to avoid excessive reduction of Cu2+ to inactive metallic Cu, which tends to decrease the catalyt...

  • Article
  • Open Access
23 Citations
6,963 Views
14 Pages

4 April 2019

Electrochemical discharge machining (ECDM) is one effective way to fabricate non-conductive materials, such as quartz glass and ceramics. In this paper, the mathematical model for the machining process of ECDM was established. Then, sets of experimen...

  • Article
  • Open Access
221 Citations
11,818 Views
17 Pages

Assessment of Wind Energy Potential for the Production of Renewable Hydrogen in Sindh Province of Pakistan

  • Wasim Iqbal,
  • Hou Yumei,
  • Qaiser Abbas,
  • Muhammad Hafeez,
  • Muhammad Mohsin,
  • Arooj Fatima,
  • Maqsood Ali Jamali,
  • Mehwish Jamali,
  • Afroze Siyal and
  • Noman Sohail

4 April 2019

In this study, we developed a new hybrid mathematical model that combines wind-speed range with the log law to derive the wind energy potential for wind-generated hydrogen production in Pakistan. In addition, we electrolyzed wind-generated power in o...

  • Article
  • Open Access
14 Citations
5,040 Views
24 Pages

4 April 2019

In this paper, we report an application for the mathematical theory of dynamic optimization for design of optimal strategies that account for daily commuting of human residents, aiming to reduce vector-borne infections (dengue) among human population...

  • Article
  • Open Access
75 Citations
6,600 Views
11 Pages

Green Synthesis of Silver Nanoparticles Using Bilberry and Red Currant Waste Extracts

  • Antonio Zuorro,
  • Annalaura Iannone,
  • Stefano Natali and
  • Roberto Lavecchia

3 April 2019

The production of silver nanoparticles (Ag-NPs) from bilberry waste (BW) and red currant waste (RCW) extracts was studied. Red fruit extracts were obtained by treating BW and RCW with aqueous ethanol (50% v/v) at 40 °C. The formation of nanoparti...

  • Feature Paper
  • Article
  • Open Access
15 Citations
14,565 Views
26 Pages

Study of Industrial Naphtha Catalytic Reforming Reactions via Modelling and Simulation

  • Aminu Zakari Yusuf,
  • B. O. Aderemi,
  • Raj Patel and
  • Iqbal M. Mujtaba

2 April 2019

Steady state and dynamic modelling and simulation of catalytic reforming unit of Kaduna Refining & Petrochemical Company, NNPC (Nigeria) was carried to find out the behaviour of the reactions under both steady and unsteady state conditions. The b...

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Processes - ISSN 2227-9717