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Processes, Volume 7, Issue 4

April 2019 - 64 articles

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Cover Story: The anti-apoptotic Mcl1 (Myeloid cell leukemia 1) protein (belonging to the Bcl2 family) is known for its overexpression and promotion of apoptosis inside cells. Because the properties of the Mcl1 binding pocket are shared among its family members, designing an inhibitor that can specifically target Mcl1 and down-regulate its activity is a highly challenging process. Lanning et al (2006) developed Mcl1-specific inhibitors that exhibited a range of binding affinities towards solid tumors and cancers. In the current investigation, we used a combination of advanced computational approaches to explore the molecular basis of its binding with Mcl1. View this paper.

Articles (64)

  • Article
  • Open Access
22 Citations
4,549 Views
15 Pages

Screening and Optimization of Demulsifiers and Flocculants Based on ASP Flooding-Produced Water

  • Bin Huang,
  • Jie Wang,
  • Wei Zhang,
  • Cheng Fu,
  • Ying Wang and
  • Xiangbin Liu

25 April 2019

The water produced by alkaline–surfactant–polymer (ASP) flooding is difficult to treat due to the presence of residual chemicals. Therefore, research and development of efficient and low-cost methods for the treatment of ASP flooding prod...

  • Article
  • Open Access
6 Citations
5,565 Views
18 Pages

Exploring Plant Sesquiterpene Diversity by Generating Chemical Networks

  • Waldeyr M. C. da Silva,
  • Jakob L. Andersen,
  • Maristela T. Holanda,
  • Maria Emília M. T. Walter,
  • Marcelo M. Brigido,
  • Peter F. Stadler and
  • Christoph Flamm

25 April 2019

Plants produce a diverse portfolio of sesquiterpenes that are important in their response to herbivores and the interaction with other plants. Their biosynthesis from farnesyl diphosphate depends on the sesquiterpene synthases that admit different cy...

  • Article
  • Open Access
6 Citations
3,516 Views
15 Pages

25 April 2019

Gas diffusivities of coal are not measured directly but are normally regressed by fitting mathematical diffusion models to fractional sorption data measured in sorption experiments. This paper firstly measured three fractional adsorption curves at va...

  • Article
  • Open Access
8 Citations
5,246 Views
10 Pages

Characterization of the Primary Sludge from Pharmaceutical Industry Effluents and Final Disposition

  • Renata Xavier Alberico Freitas,
  • Lara Aguiar Borges,
  • Handray Fernandes de Souza,
  • Fernando Colen,
  • Alex Sander Rodrigues Cangussu,
  • Eliane Macedo Sobrinho,
  • Francine Souza Alves Fonseca,
  • Sérgio Henrique Sousa Santos,
  • Bruna Mara Aparecida de Carvalho and
  • Igor Viana Brandi

24 April 2019

The generation of large volumes of waste by industrial processes has become an object of study because of the necessity to characterize the composition of residues in order to suggest appropriate treatments and to minimize adverse environmental impac...

  • Article
  • Open Access
13 Citations
4,901 Views
12 Pages

24 April 2019

The leaflet vibration phenomenon in bileaflet mechanical heart valves (BMHVs) can cause complications such as hemolysis, leaflet damage, and valve fracture. One of the main reasons for leaflet vibration is the unsteady blood flow pressure pulsation i...

  • Article
  • Open Access
9 Citations
4,562 Views
11 Pages

The Potential for a Pellet Plant to Become a Biorefinery

  • Stefan Frodeson,
  • Jonas Berghel,
  • Magnus Ståhl,
  • Karin Granström,
  • Carl Romlin and
  • Alexander Thelander

24 April 2019

The use of bioenergy has increased globally in recent years, as has the utilization of biomaterials for various new product solutions through various biorefinery concepts. In this study, we introduce the concept of using a mechanical dewatering press...

  • Feature Paper
  • Article
  • Open Access
54 Citations
15,709 Views
35 Pages

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

  • Nirupaplava Metta,
  • Michael Ghijs,
  • Elisabeth Schäfer,
  • Ashish Kumar,
  • Philippe Cappuyns,
  • Ivo Van Assche,
  • Ravendra Singh,
  • Rohit Ramachandran,
  • Thomas De Beer and
  • Marianthi Ierapetritou
  • + 1 author

24 April 2019

In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay betw...

  • Article
  • Open Access
5 Citations
5,991 Views
11 Pages

A Machine Learning-based Pipeline for the Classification of CTX-M in Metagenomics Samples

  • Diego Ceballos,
  • Diana López-Álvarez,
  • Gustavo Isaza,
  • Reinel Tabares-Soto,
  • Simón Orozco-Arias and
  • Carlos D. Ferrin

24 April 2019

Bacterial infections are a major global concern, since they can lead to public health problems. To address this issue, bioinformatics contributes extensively with the analysis and interpretation of in silico data by enabling to genetically characteri...

  • Article
  • Open Access
9 Citations
5,424 Views
14 Pages

VB1 Promoted Green Synthesis of Chalcones and Its Neuroprotection Potency Evaluation

  • Huanhuan Yin,
  • Ximeng Shi,
  • Hao Wang,
  • Guixia Liu and
  • Lei Ma

24 April 2019

For the first time, thiamine hydrochloride (VB1) has been employed as a catalyst for the synthesis of chalcones by metal-free Claisen–Schmidt condensation. Such an environmentally benign approach has several advantages such as a wide range of f...

  • Feature Paper
  • Article
  • Open Access
11 Citations
5,520 Views
24 Pages

24 April 2019

A kinetic model describing aqueous acrylamide homopolymerization and copolymerization of acrylamide with methylene bisacrylamide, leading to hydrogel formation, is presented and applied in the simulation of these reaction processes. This modeling app...

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Processes - ISSN 2227-9717Creative Common CC BY license