Table of Contents
Processes, Volume 7, Issue 3 (March 2019)
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Cover Story (view full-size image) Podocyte cells wrap around blood vessels in the kidney and play a key role in the progression of [...] Read more. Podocyte cells wrap around blood vessels in the kidney and play a key role in the progression of diabetic kidney disease (DKD). Podocytes prompt a glucose-stimulated local renin-angiotensin system (RAS) that produces angiotensin II (ANG II). ACE inhibition is a pharmaceutical approach to suppress ANG II and slow DKD progression. A PK/PD model for ACE inhibition in a local RAS network in a podocyte has been developed and compared with a systemic RAS model. The model is parameterized for normal and impaired renal function and can consider subject-specific glucose dynamics as input, enabling the study of various pathophysiological conditions. View this paper.