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Modular Engineering of Biomass Degradation Pathways

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, USA
Author to whom correspondence should be addressed.
Processes 2019, 7(4), 230;
Received: 27 February 2019 / Revised: 12 April 2019 / Accepted: 15 April 2019 / Published: 23 April 2019
(This article belongs to the Collection Principles of Modular Design and Control in Complex Systems)
Production of fuels and chemicals from renewable lignocellulosic feedstocks is a promising alternative to petroleum-derived compounds. Due to the complexity of lignocellulosic feedstocks, microbial conversion of all potential substrates will require substantial metabolic engineering. Non-model microbes offer desirable physiological traits, but also increase the difficulty of heterologous pathway engineering and optimization. The development of modular design principles that allow metabolic pathways to be used in a variety of novel microbes with minimal strain-specific optimization will enable the rapid construction of microbes for commercial production of biofuels and bioproducts. In this review, we discuss variability of lignocellulosic feedstocks, pathways for catabolism of lignocellulose-derived compounds, challenges to heterologous engineering of catabolic pathways, and opportunities to apply modular pathway design. Implementation of these approaches will simplify the process of modifying non-model microbes to convert diverse lignocellulosic feedstocks. View Full-Text
Keywords: metabolic engineering; lignin valorization; lignocellulose; biofuels; hemicellulose metabolic engineering; lignin valorization; lignocellulose; biofuels; hemicellulose
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MDPI and ACS Style

Chaves, J.E.; Presley, G.N.; Michener, J.K. Modular Engineering of Biomass Degradation Pathways. Processes 2019, 7, 230.

AMA Style

Chaves JE, Presley GN, Michener JK. Modular Engineering of Biomass Degradation Pathways. Processes. 2019; 7(4):230.

Chicago/Turabian Style

Chaves, Julie E., Gerald N. Presley, and Joshua K. Michener. 2019. "Modular Engineering of Biomass Degradation Pathways" Processes 7, no. 4: 230.

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