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Special Issue Editors

Dr. Simon S. Park

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Guest Editor

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue Boston, MA 02215 Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02215,USA
Interests: carbohydrate chemistry; process chemistry; automated synthesis; artificial intelligence

Dr. Diane D. Park

E-Mail Website
Guest Editor

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue Boston, MA 02215 Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02215, USA
Interests: mass spectrometry; high throughput screening; microfluidics; automated platforms; liquid chromatography

Special Issue Information

Dear Colleagues,

Modern technologies enable chemists to access a wide array of target compounds with minimal time requirements and costs. In particular, the commercial production of compounds of interest using automated platforms has garnered great interest. Innovative efforts to integrate automation can be transformative in the field of process chemistry, which can, in turn, have a significant impact on translational science.

This Special Issue is dedicated to the development, optimization, and innovative processes of automated technologies in process chemistry. Specifically, we invite authors to submit original research or review articles in the field of synthetic organic chemistry. The topics can include, but are not limited to, the application of flow chemistry towards diverse oriented synthesis, from batch-to-flow chemistry for the scale-up production of materials, computational design and integration of automated platforms, renewable/regenerative technologies for chemical reactions, organo-catalysis-mediated reactions, and general chemistry using artificial intelligence.

Dr. Simon S. Park
Dr. Diane D. Park
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

flow chemistry
process chemistry
automated technology
artificial intelligence
scale-up continuous reaction
medicinal chemistry
active pharmaceutical ingredient (API) production

Published Papers (2 papers)

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Research

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13 pages, 3033 KiB

Open AccessArticle

Optimization of the Production Technology of Oxidized Cyclodextrin Bisulfite

by Yana-Ya Kostyro, Anastasiya Soldatenko and Alexey Levchuk

Processes 2019, 7(7), 426; https://doi.org/10.3390/pr7070426 - 04 Jul 2019

Viewed by 2419

Abstract

The A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences has developed an original active pharmaceutical ingredient based on an oxidized cyclodextrin oligosaccharide, which is a bisulfite derivative. Conducted pharmacological studies proved its antiviral activity in vitro and in vivo experiments against the influenza A (H1N1) virus. The aim of this work was to optimize the technology of obtaining the active pharmaceutical ingredient based on the bisulfite derivative of oxidized cyclodextrin to increase the efficiency and safety of the process. For this, a scaled method of oligosaccharide oxidation was tested on pilot plants in accordance with the requirements of green chemistry. As a result, the reaction time was reduced from three to five days (laboratory conditions) to 1.5 h, and the safety and environmental friendliness of process was ensured. The use of cross-flow filtration and the method of freeze-drying eliminated 96% of ethyl alcohol, reduced the laboriousness and energy consumption of the technological operations for purification and isolation of the final product, and also increased the productivity of the whole process (output increased to 98%). The results are confirmed by data obtained by physicochemical methods. Full article

(This article belongs to the Special Issue Development of Automated Technologies in Process Chemistry)

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Review

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14 pages, 2440 KiB

Open AccessReview

Alternative Environmentally Friendly Insulating Gases for SF₆

by Yong Wang, Danqing Huang, Jing Liu, Yaru Zhang and Lian Zeng

Processes 2019, 7(4), 216; https://doi.org/10.3390/pr7040216 - 15 Apr 2019

Cited by 43 | Viewed by 6481

Abstract

Sulfur hexafluoride (SF₆) shows excellent insulation performance as an insulating gas. It is suitable for various climate conditions due to its low boiling point (−64 °C). Therefore, it has been widely used in power grid equipment. However, its global warming potential (GWP) is 23,500 times higher than that of CO₂. Thus, it is imperative to find an environmentally friendly insulating gas with excellent insulation performance, lower GWP, and which is harmless to equipment and workers to replace SF₆. In this review, four possible alternatives, including perfluorocarbons, trifluoroiodomethane, perfluorinated ketones, and fluoronitrile are reviewed in terms of basic physicochemical properties, insulation properties, decomposition properties, and compatibility with metals. The influences of trace H₂O or O₂ on their insulation performances are also discussed. The insulation strengths of these insulating gases were comparable to or higher than that of SF₆. The GWPs of these insulating gases were lower than that of SF₆. Due to their relatively high boiling point, they should be used as a mixture with buffering gases with low boiling points. Based on these four characteristics, perfluorinated ketones (C₅F₁₀O and C₆F₁₂O) and fluoronitrile (C₄F₇N) could partially substitute SF₆ in some electrical equipment. Finally, some future needs and perspectives of environmentally friendly insulating gases are addressed for further studies. Full article

(This article belongs to the Special Issue Development of Automated Technologies in Process Chemistry)

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