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Metabolites, Volume 10, Issue 3

March 2020 - 43 articles

Cover Story: We used a systems biological approach combining gene expression and metabolomics across tissues and biofluids together with metagenomics of gut microbial diversity. Here, we present the multi-omics study on liver, muscle, adipose tissue, urine, plasma, and feces on mice fed a high-fat diet (HFD). The integration of metabolomics data across tissues and biofluids identified major differences in the liver TCA cycle supported by gene expression analysis of TCA-related enzymes. Investigations of the microbiome showed enrichment of specific species in the HFD group. Our findings help to elucidate how the whole organism metabolome and transcriptome are integrated and regulated during obesity. View this paper.
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Articles (43)

  • Article
  • Open Access
26 Citations
5,273 Views
16 Pages

Discrimination of Adzuki Bean (Vigna angularis) Geographical Origin by Targeted and Non-Targeted Metabolite Profiling with Gas Chromatography Time-of-Flight Mass Spectrometry

  • Tae Jin Kim,
  • Jeong Gon Park,
  • Soon Kil Ahn,
  • Kil Won Kim,
  • Jaehyuk Choi,
  • Hyun Young Kim,
  • Sun-Hwa Ha,
  • Woo Duck Seo and
  • Jae Kwang Kim

17 March 2020

As international food trade increases, consumers are becoming increasingly interested in food safety and authenticity, which are linked to geographical origin. Adzuki beans (Vigna angularis) are cultivated worldwide, but there are no tools for accura...

  • Article
  • Open Access
18 Citations
4,710 Views
26 Pages

Compound Characterization and Metabolic Profile Elucidation after In Vitro Gastrointestinal and Hepatic Biotransformation of an Herniaria hirsuta Extract Using Unbiased Dynamic Metabolomic Data Analysis

  • Laura Peeters,
  • Anastasia Van der Auwera,
  • Charlie Beirnaert,
  • Sebastiaan Bijttebier,
  • Kris Laukens,
  • Luc Pieters,
  • Nina Hermans and
  • Kenn Foubert

16 March 2020

Herniaria hirsuta L. (Caryophyllaceae) is used for treatment of urinary stones and as a diuretic. Little is known about the active compounds and the mechanism of action. The phytochemical composition of H. hirsuta was comprehensively characterized us...

  • Article
  • Open Access
22 Citations
5,461 Views
21 Pages

Color Mutations Alter the Biochemical Composition in the San Marzano Tomato Fruit

  • Gabriella Dono,
  • Jose Luis Rambla,
  • Sarah Frusciante,
  • Antonio Granell,
  • Gianfranco Diretto and
  • Andrea Mazzucato

15 March 2020

San Marzano (SM) is a traditional Italian landrace characterized by red elongated fruits, originating in the province of Naples (Italy) and cultivated worldwide. Three mutations, yellow flesh (r), green flesh (gf) and colorless fruit epidermis (y) we...

  • Article
  • Open Access
28 Citations
3,907 Views
20 Pages

Deciphering the Metabolic Pathways of Pitaya Peel after Postharvest Red Light Irradiation

  • Qixian Wu,
  • Huijun Gao,
  • Zhengke Zhang,
  • Taotao Li,
  • Hongxia Qu,
  • Yueming Jiang and
  • Ze Yun

14 March 2020

Red light irradiation can effectively prolong the shelf-life of many fruit. However, little is known about red light-induced metabolite and enzyme activities. In this study, pitaya fruit was treated with 100 Lux red light for 24 h. Red light irradiat...

  • Article
  • Open Access
21 Citations
4,705 Views
16 Pages

Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes

  • José David Piñeiro-Ramos,
  • Antonio Núñez-Ramiro,
  • Roberto Llorens-Salvador,
  • Anna Parra-Llorca,
  • Ángel Sánchez-Illana,
  • Guillermo Quintás,
  • Nuria Boronat-González,
  • Juan Martínez-Rodilla,
  • Julia Kuligowski and
  • Máximo Vento
  • + 1 author

14 March 2020

Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling...

  • Review
  • Open Access
25 Citations
4,392 Views
19 Pages

13 March 2020

Obesity is a comorbidity that plays a role in the development and severity of inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. The relationships between obesity and adipose tissue and the t...

  • Article
  • Open Access
88 Citations
13,293 Views
20 Pages

Lipid Annotator: Towards Accurate Annotation in Non-Targeted Liquid Chromatography High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS) Lipidomics Using a Rapid and User-Friendly Software

  • Jeremy P. Koelmel,
  • Xiangdong Li,
  • Sarah M. Stow,
  • Mark J. Sartain,
  • Adithya Murali,
  • Robin Kemperman,
  • Hiroshi Tsugawa,
  • Mikiko Takahashi,
  • Vasilis Vasiliou and
  • John A. Bowden
  • + 3 authors

12 March 2020

Lipidomics has great promise in various applications; however, a major bottleneck in lipidomics is the accurate and comprehensive annotation of high-resolution tandem mass spectral data. While the number of available lipidomics software has drastical...

  • Article
  • Open Access
12 Citations
5,102 Views
16 Pages

Evaluation of the Potential Allergenicity of Strawberries in Response to Different Farming Practices

  • Mateusz Aninowski,
  • Renata Kazimierczak,
  • Ewelina Hallmann,
  • Joanna Rachtan-Janicka,
  • Elżbieta Fijoł-Adach,
  • Beata Feledyn-Szewczyk,
  • Iwona Majak and
  • Joanna Leszczyńska

12 March 2020

Fruit allergies are a large problem today. Many consumers suffer from food allergies or intolerances. The method of food production has a major impact on its quality. In fruit and vegetable production, three different farming systems are mainly found...

  • Article
  • Open Access
32 Citations
8,870 Views
18 Pages

12 March 2020

The tricarboxylic acid (TCA) cycle is a central part of carbon and energy metabolism, also connecting to glycolysis, amino acid, and lipid metabolism. The quantitation of the TCA cycle intermediate within one method is lucrative due to the interest i...

  • Review
  • Open Access
89 Citations
9,025 Views
17 Pages

Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions

  • Lorraine Smith,
  • Joran Villaret-Cazadamont,
  • Sandrine P. Claus,
  • Cécile Canlet,
  • Hervé Guillou,
  • Nicolas J. Cabaton and
  • Sandrine Ellero-Simatos

12 March 2020

Metabolomics has found numerous applications in the study of liver metabolism in health and disease. Metabolomics studies can be conducted in a variety of biological matrices ranging from easily accessible biofluids such as urine, blood or feces, to...

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Metabolites - ISSN 2218-1989