Advances in Lipidomics: Biomedicine, Nutrients and Methodology

Dear Colleagues,

Lipidomics, a primary branch of metabolomics, has rapidly developed into a discipline of research of its own. This feature has arisen from robust evidence of lipid reprogramming in the setting of metabolic disorders, cancer or cardiovascular diseases. The importance of the lipid composition in a variety of pathologies has been elucidated from alternative perspectives. Among these new perspectives, we find the dependence of membrane receptors on the lipid rafts and the impact of diet on the physiological lipid profile. Additionally, in the last decade, potential biomarkers for early diagnosis and novel therapeutic targets have emerged. For example, lipidome profiling is promising for improving clinical treatments such as cancer immunotherapy. The improvement in the applications in the clinics is in direct relation to technical development. Relevant advances in lipid analysis have been reached using soft-ionization techniques in mass spectrometry and new developments in data pretreatment. However, data pretreatment applied to compound identification/quantification and reproducibility continues to be an analytical limit of lipidomics. In this Special Issue, researchers from the lipidomics field are encouraged to submit manuscripts concerning both targeted and untargeted lipid profiling, which focus on biomedicine and health-related nutritional studies. In particular, reviews and original studies that bolster signaling pathways and their influence on metabolism are preferred. Reviews and original studies that delve into a broad range of methodological advances including instrumentation, sample preparation and workflows, bioinformatics-based data analysis, and databases are also especially welcome.

Dr. Olimpio Montero
Dr. David Balgoma
Dr. Luis Gil-de-Gómez
Guest Editors

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