Special Issue "Exercise Metabonomics"

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Vassilis Mougios

Aristotle University of Thessaloniki, Thessaloniki, Greece
Website | E-Mail
Interests: exercise biochemistry and physiology; exercise metabolomics; sport nutrition

Special Issue Information

Dear Colleagues,

Metabolomics is being increasingly appreciated as an integral part of systems biology. Possessing the advantage of affording a holistic view of metabolism, metabolomics has been used repeatedly over the past decade in the study of the effects of exercise, both acute and chronic, on human and animal metabolism. Thus, the field of exercise metabonomics has emerged, which can be defined as the large-scale, comprehensive study of the effects of exercise on the metabolome. The aim of this Special Issue is to advance this field by providing a forum for the presentation of research findings based on a metabolomics approach and related to the modulation of metabolism by different exercise parameters (such as type, intensity, duration, and whether it is acute or chronic), characteristics of the exercising organism (such as sex, age, nutritional state, training state, and the genome), and environmental factors (such as ambient temperature and hypoxia).

Prof. Dr. Vassilis Mougios
Guest Editor

Manuscript Submission Information

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Keywords

  • exercise
  • metabolomics/metabonomics
  • physical activity

Published Papers (2 papers)

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Research

Open AccessArticle
Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
Metabolites 2019, 9(4), 71; https://doi.org/10.3390/metabo9040071
Received: 21 March 2019 / Revised: 10 April 2019 / Accepted: 11 April 2019 / Published: 13 April 2019
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Abstract
South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and [...] Read more.
South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood samples collected from 16 South Asian and 16 white European men and explored associations with body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate; p ≤ 0.040), lower acylated ghrelin (ES = 1.00, p = 0.008) and higher leptin (ES = 1.11, p = 0.004) than white Europeans; total peptide YY was similar between groups (p = 0.381). South Asians exhibited elevated fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES ≥ 0.74, p ≤ 0.053). Controlling for body fat percentage (assessed using air displacement plethysmography) attenuated these differences. Despite similar habitual moderate-to-vigorous physical activity (ES = 0.18, p = 0.675), V ˙ O2max was lower in South Asians (ES = 1.36, p = 0.001). Circulating FFAs in South Asians were positively correlated with body fat percentage (r2 = 0.92), body mass (r2 = 0.86) and AUC glucose (r2 = 0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r2 = 0.96). In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans. Full article
(This article belongs to the Special Issue Exercise Metabonomics)
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Open AccessArticle
The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure
Metabolites 2019, 9(3), 53; https://doi.org/10.3390/metabo9030053
Received: 22 January 2019 / Revised: 12 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
PDF Full-text (3364 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in [...] Read more.
The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in vivo. After surgically establishing HF in rats, we randomized the rats to exercise training programs of different intensities. After the final training session, rats were sacrificed and tissues from the myocardial and skeletal muscle were extracted. Magnetic resonance spectra were acquired from these extracts, and principal component and metabolic enrichment analysis were used to assess the differences in metabolic profiles. The results indicated that HF affected myocardial metabolism by changing multiple metabolites, whereas it had a limited effect on skeletal muscle metabolism. Moreover, exercise training mainly altered the metabolite distribution in skeletal muscle, indicating regulation of metabolic pathways of taurine and hypotaurine metabolism and carnitine synthesis. Full article
(This article belongs to the Special Issue Exercise Metabonomics)
Figures

Figure 1

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