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Biology, Volume 8, Issue 2

June 2019 - 31 articles

Cover Story: Ever since ancient times, humans have been fascinated by the roots of aging and the fountain of youth. Unifying features of the aging process, lysosomal storage diseases and neurodegenerative conditions include the cumulative buildup of oxidative damage, protein aggregates, and toxic waste. Organelles that regulate reactive oxygen species (ROS) production, quality control/repair, and recycling comprise the major defense systems against aging. Arguably, mitochondria are ‘the hubs of aerobic life’ given their role in eukaryotic evolution and the rise of complex life. Mitochondria are related to biological aging by regulating energy production, ROS generation, Ca2+ handling, inflammation, and apoptosis. Exercise therapeutics rejuvenates mitochondria and decelerates the ‘vicious cycle’ of cell aging, thereby extending mammalian life- and health- span. View this paper
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Articles (31)

  • Article
  • Open Access
13 Citations
10,985 Views
11 Pages

Intergeneric Hybrid from Jatropha curcas L. and Ricinus communis L.: Characterization and Polyploid Induction

  • Duangporn Premjet,
  • Abraham Kusi Obeng,
  • Anupan Kongbangkerd and
  • Siripong Premjet

22 June 2019

Jatropha curcas L. (2n = 2× = 22) is increasingly attracting attention in the biodiesel industry for its oil. However, the cultivation of J. curcas L. is faced with numerous challenges unlike the cultivation of Ricinus communis L. (2n = 2×...

  • Article
  • Open Access
10 Citations
5,244 Views
18 Pages

Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome

  • Pavel V. Ershov,
  • Yuri V. Mezentsev,
  • Arthur T. Kopylov,
  • Evgeniy O. Yablokov,
  • Andrey V. Svirid,
  • Aliaksandr Ya. Lushchyk,
  • Leonid A. Kaluzhskiy,
  • Andrei A. Gilep,
  • Sergey A. Usanov and
  • Alexey E. Medvedev
  • + 1 author

20 June 2019

Prostacyclin synthase (PTGIS; EC 5.3.99.4) catalyzes isomerization of prostaglandin H2 to prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. At present, limited data exist on functional coupling and possible ways of regulating...

  • Article
  • Open Access
15 Citations
4,918 Views
15 Pages

Identification and Characterization of microRNAs and Their Predicted Functions in Biomineralization in the Pearl Oyster (Pinctada fucata)

  • Songqian Huang,
  • Yuki Ichikawa,
  • Kazutoshi Yoshitake,
  • Shigeharu Kinoshita,
  • Yoji Igarashi,
  • Fumito Omori,
  • Kaoru Maeyama,
  • Kiyohito Nagai,
  • Shugo Watabe and
  • Shuichi Asakawa

17 June 2019

The biological process of pearl formation is an ongoing research topic, and a number of genes associated with this process have been identified. However, the involvement of microRNAs (miRNAs) in biomineralization in the pearl oyster, Pinctada fucata,...

  • Article
  • Open Access
9 Citations
5,495 Views
14 Pages

14 June 2019

We studied the effects of metabolic cold adaptation (MCA) in two populations of a eurythermal species, spotted seatrout (Cynoscion nebulosus) along the U.S. East Coast. Fish were captured from their natural environment and acclimated at control tempe...

  • Article
  • Open Access
5 Citations
4,449 Views
9 Pages

11 June 2019

Mouse Leydig Tumor cells (mLTC), transiently expressing cAMP-dependent luciferase, were used to study the influence of sexual steroids and of adiponectin (ADPN) on the cAMP response to luteinizing hormones (LH). While testosterone and progesterone ha...

  • Article
  • Open Access
11 Citations
5,346 Views
8 Pages

10 June 2019

Background: Exercise induces many physiological adaptations. Recently, it has been proposed that some of these adaptations are induced by exercise-mediated lactate production. In this study, we aimed to investigate in vitro the effect of lactate in c...

  • Opinion
  • Open Access
11 Citations
6,431 Views
14 Pages

Amyloidosis and Longevity: A Lesson from Plants

  • Andrei Surguchov,
  • Fatemeh Nouri Emamzadeh and
  • Alexei A. Surguchev

The variety of lifespans of different organisms in nature is amazing. Although it is acknowledged that the longevity is determined by a complex interaction between hereditary and environmental factors, many questions about factors defining lifespan r...

  • Article
  • Open Access
18 Citations
6,076 Views
19 Pages

Which Species Should We Focus On? Umbrella Species Assessment in Southwest China

  • Xuewei Shi,
  • Cheng Gong,
  • Lu Zhang,
  • Jian Hu,
  • Zhiyun Ouyang and
  • Yi Xiao

In conservation biology, umbrella species are often used as agents for a broader set of species, or as representatives of an ecosystem, and their conservation is expected to benefit a large number of naturally co-occurring species. Southwest China is...

  • Review
  • Open Access
38 Citations
10,842 Views
19 Pages

Are There Circadian Clocks in Non-Photosynthetic Bacteria?

  • Francesca Sartor,
  • Zheng Eelderink-Chen,
  • Ben Aronson,
  • Jasper Bosman,
  • Lauren E. Hibbert,
  • Antony N. Dodd,
  • Ákos T. Kovács and
  • Martha Merrow

Circadian clocks in plants, animals, fungi, and in photosynthetic bacteria have been well-described. Observations of circadian rhythms in non-photosynthetic Eubacteria have been sporadic, and the molecular basis for these potential rhythms remains un...

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Biology - ISSN 2079-7737