Table of Contents
Biology, Volume 8, Issue 2 (June 2019) – 31 articles
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Cover Story (view full-size image) Ever since ancient times, humans have been fascinated by the roots of aging and the fountain of [...] Read more. Ever since ancient times, humans have been fascinated by the roots of aging and the fountain of youth. Unifying features of the aging process, lysosomal storage diseases and neurodegenerative conditions include the cumulative buildup of oxidative damage, protein aggregates, and toxic waste. Organelles that regulate reactive oxygen species (ROS) production, quality control/repair, and recycling comprise the major defense systems against aging. Arguably, mitochondria are ‘the hubs of aerobic life’ given their role in eukaryotic evolution and the rise of complex life. Mitochondria are related to biological aging by regulating energy production, ROS generation, Ca2+ handling, inflammation, and apoptosis. Exercise therapeutics rejuvenates mitochondria and decelerates the ‘vicious cycle’ of cell aging, thereby extending mammalian life- and health- span. View this paper