Special Issue "Mitochondrial Dysfunction in Aging and Diseases of Aging"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (30 November 2018).
A printed edition of this Special Issue is available here.
Mitochondria have been increasing recognized as important players in the aging process. Most aging related diseases and particularly neurodegenerative diseases have mitochondrial involvement. A PubMed search for mitochondria and aging lists 348 articles in the first seven months of 2018. This is not surprising as mitochondria are involved not only in energy production through oxidative phosphorylation but also play an important role in intracellular homeostasis, calcium balance and the metabolism and interconversion of our dietary substrates; fats, proteins and carbohydrates in the fed and fasting states. They have an important role in signaling their metabolic state to the nucleus, and to other cells and in the response to stress. Mitochondria have their own protein synthetic apparatus and replicate themselves, pathways readily disrupted in disease and aging. They are constantly involved in fusion and fission the balance of which is essential for cell health. These organelles participate in apoptosis, they make most of the cell’s free radicals and they are crucially important for innate immunity. Mitochondrial DNA has an estimated 10-fold greater mutation rate than nuclear DNA and less repair capacity, this plays an important role in aging and cancer. Mitochondria are impacted by environmental factors and toxins and different mtDNA haplogroups originally adapted to geographically different origins make an important background contribution to disease. As mitochondria play a critical metabolic role in all organ systems they are particularly impacted by disease and contribute to the aging process itself. The invited review articles in this special supplement cover most of the common diseases of aging. Enthusiasm for this supplement in Biology is driven by the opportunity to review the current state of knowledge about the role of mitochondria in the aging process. The international group of contributing authors include many of the leaders in their fields.
Prof. Dr. Richard H. Haas
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- Aging Diseases