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Biology, Volume 8, Issue 3 (September 2019)
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Cover Story (view full-size image) Cell division culminates with physical division of the mother cell, which produces two daughter [...] Read more. Cell division culminates with physical division of the mother cell, which produces two daughter cells through a process known as cytokinesis. Cytokinesis failure results in binucleated polyploid cells, an aberrant physiological state that has been linked to cancer development. Therefore, it is vital for cells to complete cytokinesis with high fidelity. A key first step in cytokinesis involves signaling pathways that spatially define where the contractile ring (CR) assembles. Multiple mechanisms in different model organisms have been proposed to contribute to CR positioning. Central to all these mechanisms are microtubules; however, the molecular details of microtubule-based signaling in CR specification remain elusive. In this review, Verma et al. discuss and evaluate classical and emerging regulatory mechanisms of cytokinesis. View this paper