Table of Contents
Biology, Volume 8, Issue 1 (March 2019) – 19 articles
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Cover Story (view full-size image) The identification of genes encoding circadian clock components allow molecular genetic approaches [...] Read more. The identification of genes encoding circadian clock components allow molecular genetic approaches to reveal the inner workings of cell-autonomous circadian clocks. In mammals, cellular clocks are active in all organs, regulating ca. 60% of all genes expressed across the body. Local clocks thereby direct strict 24-hour programmes of metabolism and behaviour, and their disruption bears a heavy cost on health. Critically, the suprachiasmatic nucleus (SCN) of the hypothalamus is the pacemaker of this network. The review by Hastings et al. advances our understanding of how intercellular signalling across the SCN circuit enables it to generate the extremely robust and precise signals that define our daily lives. Thus, this circadian Vitruvian Man can be viewed as a servant of two masters in that circadian time keeping in the SCN depends on the interplay of day-active SCN neurons and night-active astrocytes. View this paper