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Biology 2019, 8(2), 24; https://doi.org/10.3390/biology8020024

The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity

Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
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Received: 7 March 2019 / Revised: 1 April 2019 / Accepted: 9 April 2019 / Published: 13 April 2019
(This article belongs to the Special Issue New Players in Adipocyte Biology)
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Abstract

Cardiotrophin-1 (CT-1) is a gp130 cytokine that was previously characterized for its effects on cardiomyocytes and identified as a marker of heart failure. More recent studies reported elevated circulating levels of CT-1 in humans with obesity and metabolic syndrome (MetS). However, a subsequent rodent study implicated CT-1 as a potential therapeutic target for obesity and MetS. Adipose tissue (AT) is broadly acknowledged as an endocrine organ and is a substantial source of CT-1. However, no study has examined the expression of adipose-derived CT-1 in humans. We present the first analysis of CT-1 mRNA expression in subcutaneous AT and its association with clinical variables in 22 women with obesity and 15 men who were 40% overfed for 8-weeks. We observed that CT-1 expression was higher in the subcutaneous abdominal (scABD) than the femoral (scFEM) depot. Importantly, we reveal that scFEM but not scABD, CT-1 expression was negatively associated with visceral adiposity and intrahepatic lipid, while positively correlated with insulin sensitivity in obese women. Also, men with higher CT-1 levels at baseline had less of a decline in insulin sensitivity in response to overfeeding. Our data provide new knowledge on the regulation of adipose-derived CT-1 in obesity and during weight gain in response to overfeeding in humans and suggest that CT-1 may play a protective role in obesity and related disorders. View Full-Text
Keywords: gp130 cytokines; cardiotrophin-1; adipose tissue; abdominal; femoral; obesity; metabolic health; clinical variables gp130 cytokines; cardiotrophin-1; adipose tissue; abdominal; femoral; obesity; metabolic health; clinical variables
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Stephens, J.; Ravussin, E.; White, U. The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity. Biology 2019, 8, 24.

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