Next Article in Journal / Special Issue
Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
Previous Article in Journal / Special Issue
Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview

Mitochondrial Dysfunction and Multiple Sclerosis

Department of Neurosciences, University of California San Diego, San Diego, CA 92093-0935, USA
Author to whom correspondence should be addressed.
Biology 2019, 8(2), 37;
Received: 7 February 2019 / Revised: 8 April 2019 / Accepted: 30 April 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
PDF [1506 KB, uploaded 14 May 2019]


In recent years, several studies have examined the potential associations between mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS), Parkinson’s disease and Alzheimer’s disease. In MS, neurological disability results from inflammation, demyelination, and ultimately, axonal damage within the central nervous system. The sustained inflammatory phase of the disease leads to ion channel changes and chronic oxidative stress. Several independent investigations have demonstrated mitochondrial respiratory chain deficiency in MS, as well as abnormalities in mitochondrial transport. These processes create an energy imbalance and contribute to a parallel process of progressive neurodegeneration and irreversible disability. The potential roles of mitochondria in neurodegeneration are reviewed. An overview of mitochondrial diseases that may overlap with MS are also discussed, as well as possible therapeutic targets for the treatment of MS and other neurodegenerative conditions. View Full-Text
Keywords: multiple sclerosis; mitochondria; neuroinflammation; neurodegeneration multiple sclerosis; mitochondria; neuroinflammation; neurodegeneration

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Barcelos, I.P.; Troxell, R.M.; Graves, J.S. Mitochondrial Dysfunction and Multiple Sclerosis. Biology 2019, 8, 37.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top