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Cardiovascular Manifestations of Mitochondrial Disease

Department of Cardiology, University of California San Diego Medical Center, La Jolla, CA 92037, USA
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Biology 2019, 8(2), 34; https://doi.org/10.3390/biology8020034
Received: 27 February 2019 / Revised: 13 April 2019 / Accepted: 22 April 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases of Ageing)
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PDF [470 KB, uploaded 14 May 2019]

Abstract

Genetic mitochondrial cardiomyopathies are uncommon causes of heart failure that may not be seen by most physicians. However, the prevalence of mitochondrial DNA mutations and somatic mutations affecting mitochondrial function are more common than previously thought. In this review, the pathogenesis of genetic mitochondrial disorders causing cardiovascular disease is reviewed. Treatment options are presently limited to mostly symptomatic support, but preclinical research is starting to reveal novel approaches that may lead to better and more targeted therapies in the future. With better understanding and clinician education, we hope to improve clinician recognition and diagnosis of these rare disorders in order to improve ongoing care of patients with these diseases and advance research towards discovering new therapeutic strategies to help treat these diseases. View Full-Text
Keywords: mitochondrial; genetic mutations; cardiovascular disease; heart failure; cardiomyopathy mitochondrial; genetic mutations; cardiovascular disease; heart failure; cardiomyopathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Duran, J.; Martinez, A.; Adler, E. Cardiovascular Manifestations of Mitochondrial Disease. Biology 2019, 8, 34.

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